Designing a biostable L-DNAzyme for lead( ii ) ion detection in practical samples
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We have constructed a nuclease resistant sensor based on L-DNAzyme for Pd 2+ detection in real water samples and serum solutions.
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Several groups have successfully used l-DNA and l-RNA biosensors in living cells.
“Towards this goal, several groups have successfully employed l-DNA and l-RNA-based biosensors in living cells, supporting the viability of the mirror-image approach.10–13”
From Direct Comparison of <scp>d</scp>-DNA and <scp>l</scp>-DNA Strand-Displacement Reactions in Living Mammalian Cells (2021) · cites this paper as [13]
The Results (section 3.5) report successful use of an L-DNAzyme biosensor to detect lead in river water and fetal bovine serum. The Conclusion likewise identifies water and serum as the tested samples. The paper does not report biosensing in living cells or the use of an L-RNA biosensor, so it supports only part of the attributed claim. (LLM, conf=0.88)
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- Authors
- Liang, H., Xie, S., Cui, L., Wu, C., & Zhang, X.
- Affiliations
- Hunan University (CN)
- Amgen (United States) (US)
- Corresponding author
- Cui, Liang
- Zhang, Xiaobing
- Venue
- Analytical Methods
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 8
- Issue
- 39
- Pages
- 7260-7264
- ISSN
- 1759-9660 (ISSN-L)
- 1759-9679
- PMC
- PMC5650247
- OpenAlex
- W2514517937
- Semantic Scholar
- 772a3f92b657007d2ef864ebee2a8c6536e2df1e
- Cited by
- 24
- References
- 41
- Citations by year
- 2024: 2 · 2023: 3 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 1 · 2017: 3
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Analytical Methods (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Natural Science Foundation of China
- National Cancer Institute (R01CA133086)
- National Institute of General Medical Sciences (R01GM079359)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- lead ion detection, metal ion sensing, water samples, serum samples, biosensors
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