The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?
Open accessAbstract
Nanotechnology offers several attractive design features that have prompted its exploration for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the ability to protect the payload from degradation, a large surface on which to conjugate targeting ligands, and controlled or sustained release. Nanosized drugs also leak preferentially into tumor tissue through permeable tumor vessels and are then retained in the tumor bed due to reduced lymphatic drainage. This process is known as the enhanced permeability and retention (EPR) effect. However, while the EPR effect is widely held to improve delivery of nanodrugs to tumors, it in fact offers less than a 2-fold increase in nanodrug delivery compared with critical normal organs, resulting in drug concentrations that are not sufficient for curing most cancers. In this Review, we first overview various barriers for nanosized drug delivery with an emphasis on the capillary wall's resistance, the main obstacle to delivering drugs. Then, we discuss current regulatory issues facing nanomedicine. Finally, we discuss how to make the delivery of nanosized drugs to tumors more effective by building on the EPR effect.
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The entry of nanoparticles into solid tumours
Sindhwani, S., Syed, A. M., Ngai, J., Kingston, B. R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N. U., Hoang, T., et al. (2020) · Nature Materials · doi:10.1038/s41563-019-0566-2 · Cited by 1,732
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
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Mesoporous Silica Nanoparticles for Drug Delivery
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Molecularly Imprinted Polymers: Antibody Mimics for Bioimaging and Therapy
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Hersh, A. M., Alomari, S., & Tyler, B. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084153 · Cited by 478
Metadata
- Authors
- Nakamura, Y., Mochida, A., Choyke, P. L., & Kobayashi, H.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-09-02
- Volume
- 27
- Issue
- 10
- Pages
- 2225-2238
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2518509288
- Cited by
- 1,101
- References
- 25
- FWCI
- 29.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Nakamura, Y., Mochida, A., Choyke, P. L., & Kobayashi, H. (2016). Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer? Bioconjugate Chemistry. https://doi.org/10.1021/acs.bioconjchem.6b00437
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