Blended Assemblies of Amphiphilic Random and Block Copolymers for Tunable Encapsulation and Release of Hydrophobic Guest Molecules
Abstract
Self-assembly of amphiphilic polymers in aqueous solution builds up versatile carrier platforms for therapeutic delivery. Amphiphilic polymers specifically provide “hydrophobic pockets” for the encapsulation of water-insoluble small-molecule drugs, along with effective strategies to control the cargo release. Random and block copolymers have been separately demonstrated to affect the cargo encapsulation and release. In this study, we present self-assembled structures of blended random and block copolymers to tune the encapsulation and release of lipophilic cargo molecules. The hydrophilic–lipophilic balance (HLB) within the polymeric (co-)assemblies greatly affects their cargo loading capacity. Meanwhile, the disulfide moieties within the polymeric assemblies allow controlled cargo release upon a redox stimulus such as glutathione. The triggered release of encapsulated cargos is affected by the overall HLB, the reactivity, and accessibility of the disulfide species within the polymeric assemblies.
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Previous studies have highlighted that not only composition, but also architecture and monomer distributions of copolymers could strongly affect their thermal, mechanical and aggregation properties.
“Previous studies have highlighted that not only the composition, but also the architecture and monomers distributions of copolymers could strongly affect their thermal, mechanical and aggregation properties [36,37,38].”
From Thermo-Rheological and Shape Memory Properties of Block and Random Copolymers of Lactide and ε-Caprolactone (2021) · cites this paper as [38]
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Naddeo, M., Sorrentino, A., & Pappalardo, D. (2021) · Polymers · doi:10.3390/polym13040627 · Cited by 25 · see citing works
- Authors
- Jiang, Z., Liu, H., He, H., Ribbe, A. E., & Thayumanavan, S.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Thayumanavan, S.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-03-19
- Volume
- 53
- Issue
- 7
- Pages
- 2713-2723
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W3012308480
- Cited by
- 57
- References
- 49
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 25 · 2020: 4
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Macromolecules (publishedVersion)
- Funders
- Army Research Office (W911NF-15-1-0568)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Keywords
- amphiphilic block copolymers, random copolymers, polymer blends, self-assembly, controlled release, hydrophobic-lipophilic balance, disulfide bonds, glutathione-responsive release, redox-responsive polymers, drug carriers
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