Cited by 57Advanced Polymer Synthesis and CharacterizationNanoparticle-Based Drug DeliverySurfactants and Colloidal Systems

Blended Assemblies of Amphiphilic Random and Block Copolymers for Tunable Encapsulation and Release of Hydrophobic Guest Molecules

Jiang, Ziwen, Liu, Hongxu, He, Huan, Ribbe, Alexander E., Thayumanavan, S.·2020·Macromolecules

Abstract

Self-assembly of amphiphilic polymers in aqueous solution builds up versatile carrier platforms for therapeutic delivery. Amphiphilic polymers specifically provide “hydrophobic pockets” for the encapsulation of water-insoluble small-molecule drugs, along with effective strategies to control the cargo release. Random and block copolymers have been separately demonstrated to affect the cargo encapsulation and release. In this study, we present self-assembled structures of blended random and block copolymers to tune the encapsulation and release of lipophilic cargo molecules. The hydrophilic–lipophilic balance (HLB) within the polymeric (co-)assemblies greatly affects their cargo loading capacity. Meanwhile, the disulfide moieties within the polymeric assemblies allow controlled cargo release upon a redox stimulus such as glutathione. The triggered release of encapsulated cargos is affected by the overall HLB, the reactivity, and accessibility of the disulfide species within the polymeric assemblies.

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Crossref · 10.1021/acs.macromol.9b02595

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49 of 49 references verified0 citation errors · 0 not checkable

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  • Previous studies have highlighted that not only composition, but also architecture and monomer distributions of copolymers could strongly affect their thermal, mechanical and aggregation properties.

    “Previous studies have highlighted that not only the composition, but also the architecture and monomers distributions of copolymers could strongly affect their thermal, mechanical and aggregation properties [36,37,38].”

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Authors
Jiang, Z., Liu, H., He, H., Ribbe, A. E., & Thayumanavan, S.
Affiliations
University of Massachusetts Amherst (US)
Corresponding author
Thayumanavan, S.
Venue
Macromolecules
Published
2020-03-19
Volume
53
Issue
7
Pages
2713-2723
ISSN
  • 0024-9297 (ISSN-L)
  • 1520-5835
OpenAlex
W3012308480
Cited by
57
References
49
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 25 · 2020: 4
FWCI
4.46
Type
journal article
Language
en
Open access
closed
Locations
Macromolecules (publishedVersion)
Funders
Army Research Office (W911NF-15-1-0568)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Keywords
amphiphilic block copolymers, random copolymers, polymer blends, self-assembly, controlled release, hydrophobic-lipophilic balance, disulfide bonds, glutathione-responsive release, redox-responsive polymers, drug carriers

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