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Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure–Activity Relationship

Sahariah, Priyanka, Másson, Már·2017·Biomacromolecules

Abstract

This review gives an updated overview of the current state-of-the-art for antimicrobial chitosan and chitosan derivatives and the effects of structural modifications on activity and toxicity. The various synthetic routes introduced for chemical modification of chitosan are discussed, and the most common functional groups are highlighted. Different analytical techniques used for structural characterization of the synthesized chitosan derivatives are discussed and critically evaluated. For the purpose of this review, the antimicrobial chitosan derivatives have been classified on the basis of the type of functional group conjugated to the polymer backbone. In each case, the influence of the degree of substitution on the biological properties has been examined. Finally, we have summarized the collective information and suggested future directions for further research to improve our understanding of the bioactivity and to develop more useful chitosan conjugates.

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Metadata

Authors
Sahariah, P., & Másson, M.
Venue
Biomacromolecules
Published
2017-10-03
Volume
18
Issue
11
Pages
3846-3868
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W2757652705
Cited by
994
References
5
FWCI
17.50
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure–Activity Relationship. https://app.cochat.ai/papers/10.1021/acs.biomac.7b01058
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Sahariah, P., & Másson, M. (2017). Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure–Activity Relationship. Biomacromolecules. https://doi.org/10.1021/acs.biomac.7b01058

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.