The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
TiO2 Nanosheets with the Au Nanocrystal-Decorated Edge for Mitochondria-Targeting Enhanced Sonodynamic Therapy
Abstract
Sonodynamic therapy (SDT) has attracted much attention since it can break the depth-penetration barrier of phototriggered therapeutic strategies. However, developing sonosensitizers with a high reactive oxygen species (ROS) quantum yield for precision and enhanced SDT remains a major challenge. In this study, Au nanocrystals were selectively grew on the edge of the TiO 2 nanosheets (NSs) with highly exposed (001) facets to fabricate Au-TiO 2 NSs as sonosensitizers for enhanced SDT. The high sonosensitization efficiency was closely linked to the effective prevention of the fast recombination of excited electrons and holes. Under ultrasound (US) irradiation, the ROS generation efficiency of the resulting Au-TiO 2 NSs was higher compared to pure TiO 2 NSs and superior to previous TiO 2 nanocomposite. The Au-TiO 2 was further modified with mitochondria-targeted triphenylphosphine (TPP) and AS1411 aptamer (Au-TiO 2 -A-TPP) to realize organelle-targeted enhanced SDT and CT (computed tomography) imaging. The tumor growth inhibition was completely realized via Au-TiO 2 -A-TPP-mediated SDT both in vitro and in vivo due to the adequate ROS generation in the mitochondria organelle. This knowledge is vital to design an inorganic sonosensitizer with structure-dependent and mitochondria-target related SDT enhancement.
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Cites
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Mitochondria and cell death: outer membrane permeabilization and beyond
Tait, S. W. G., & Green, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2952 · Cited by 2,593
Imaging macrophages with nanoparticles
Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809
Cited by
Advanced biotechnology-assisted precise sonodynamic therapy
Zhang, Y., Zhang, X., Yang, H., Yu, L., Xu, Y., Sharma, A., Yin, P., Li, X., Kim, J. S., & Sun, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00403d · Cited by 498
Self-citationConferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy
Liang, S., Xiao, X., Bai, L., Liu, B., Yuan, M., Ma, P., Pang, M., Cheng, Z., & Lin, J. (2021) · Advanced Materials · doi:10.1002/adma.202100333 · Cited by 359
Recent advances in nanomaterial-based augmented sonodynamic therapy of cancer
Um, W., E. K., P. K., Lee, J., Kim, C. H., You, D. G., & Park, J. H. (2021) · Chemical Communications · doi:10.1039/d0cc07750j · Cited by 120
Design and application of inorganic nanoparticles for sonodynamic cancer therapy
Sun, L., Wang, P., Zhang, J., Sun, Y., Sun, S., Xu, M., Zhang, L., Wang, S., Liang, X., & Cui, L. (2021) · Biomaterials Science · doi:10.1039/d0bm01875a · Cited by 115
Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy
He, Z., Du, J., Miao, Y., & Li, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300234 · Cited by 105
Metadata
- Authors
- Cao, Y., Wu, T., Dai, W., Dong, H., & Zhang, X.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-10-17
- Volume
- 31
- Issue
- 21
- Pages
- 9105-9114
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2981317126
- Cited by
- 189
- References
- 3
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cao, Y., Wu, T., Dai, W., Dong, H., & Zhang, X. (2019). TiO2 Nanosheets with the Au Nanocrystal-Decorated Edge for Mitochondria-Targeting Enhanced Sonodynamic Therapy. Chemistry of Materials. https://doi.org/10.1021/acs.chemmater.9b03430
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