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Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.
Abstract
Degradable polymers are used widely in tissue engineering and regenerative medicine. Maturing capabilities in additive manufacturing coupled with advances in orthogonal chemical functionalization methodologies have enabled a rapid evolution of defect-specific form factors and strategies for designing and creating bioactive scaffolds. However, these defect-specific scaffolds, especially when utilizing degradable polymers as the base material, present processing challenges that are distinct and unique from other classes of materials. The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.
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“it can accurately and quickly fabricate scaffolds with precise geometry and high pore connectivity, similar to native tissues [13][14][15][16][17]”
From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [15]
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Metadata
- Authors
- Kirillova, A., Yeazel, T. R., Asheghali, D., Petersen, S. R., Dort, S., Gall, K., & Becker, M. L.
- Affiliations
- Duke University (US)
- Corresponding author
- Becker, Matthew L.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-04-15
- Volume
- 121
- Issue
- 18
- Pages
- 11238-11304
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W3155020406
- Cited by
- 368
- References
- 459
- Citations by year
- 2026: 66 · 2025: 96 · 2024: 95 · 2023: 57 · 2022: 44 · 2021: 10
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Division of Materials Research (1507420)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- biodegradable polymers, biomedical scaffolds, scaffold fabrication, tissue engineering, additive manufacturing, chemical functionalization, regenerative medicine, scaffold design
- MeSH terms
- Biocompatible Materials, Polymers, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds
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