Cited by 369biodegradable polymer synthesis and propertiesBone Tissue Engineering Materials3D Printing in Biomedical Research

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Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.

Kirillova, Alina, Yeazel, Taylor R., Asheghali, Darya, Petersen, Shannon R., Dort, Sophia, Gall, Ken, Becker, Matthew L.·2021·Chemical Reviews

DOI 10.1021/acs.chemrev.0c01200

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Abstract

Degradable polymers are used widely in tissue engineering and regenerative medicine. Maturing capabilities in additive manufacturing coupled with advances in orthogonal chemical functionalization methodologies have enabled a rapid evolution of defect-specific form factors and strategies for designing and creating bioactive scaffolds. However, these defect-specific scaffolds, especially when utilizing degradable polymers as the base material, present processing challenges that are distinct and unique from other classes of materials. The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.

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Authors: Kirillova, A., Yeazel, T. R., Asheghali, D., Petersen, S. R., Dort, S., Gall, K., & Becker, M. L.
Affiliations: Duke University (US)
Corresponding author: Becker, Matthew L.
ORCID: Kirillova, Alina
Asheghali, Darya
Dort, Sophia
Gall, Ken
Becker, Matthew L.
Venue: Chemical Reviews
Publisher: American Chemical Society (ACS)
Published: 2021-04-15
Volume: 121
Issue: 18
Pages: 11238-11304
ISSN: 0009-2665 (ISSN-L)
1520-6890
DOI: 10.1021/acs.chemrev.0c01200
OpenAlex: W3155020406
Cited by: 368
References: 459
Citations by year: 2026: 66 · 2025: 96 · 2024: 95 · 2023: 57 · 2022: 44 · 2021: 10
FWCI: 3.57
Type: journal article
Language: en
Open access: closed
Licence: doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-045 (stm-asf)
Locations: Chemical Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Division of Materials Research (1507420)
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords: biodegradable polymers, biomedical scaffolds, scaffold fabrication, tissue engineering, additive manufacturing, chemical functionalization, regenerative medicine, scaffold design
MeSH terms: Biocompatible Materials, Polymers, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds

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Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.

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