The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Water Determines the Structure and Dynamics of Proteins
Open accessAbstract
Water is an essential participant in the stability, structure, dynamics, and function of proteins and other biomolecules. Thermodynamically, changes in the aqueous environment affect the stability of biomolecules. Structurally, water participates chemically in the catalytic function of proteins and nucleic acids and physically in the collapse of the protein chain during folding through hydrophobic collapse and mediates binding through the hydrogen bond in complex formation. Water is a partner that slaves the dynamics of proteins, and water interaction with proteins affect their dynamics. Here we provide a review of the experimental and computational advances over the past decade in understanding the role of water in the dynamics, structure, and function of proteins. We focus on the combination of X-ray and neutron crystallography, NMR, terahertz spectroscopy, mass spectroscopy, thermodynamics, and computer simulations to reveal how water assist proteins in their function. The recent advances in computer simulations and the enhanced sensitivity of experimental tools promise major advances in the understanding of protein dynamics, and water surely will be a protagonist.
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Cited by
Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine
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Metadata
- Authors
- Bellissent-Funel, M.-C., Hassanali, A., Havenith, M., Henchman, R., Pohl, P., Sterpone, F., van der Spoel, D., Xu, Y., & Garcia, A. E.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-05-17
- Volume
- 116
- Issue
- 13
- Pages
- 7673-7697
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2395521783
- Cited by
- 945
- References
- 11
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Bellissent-Funel, M.-C., Hassanali, A., Havenith, M., Henchman, R., Pohl, P., Sterpone, F., van der Spoel, D., Xu, Y., & Garcia, A. E. (2016). Water Determines the Structure and Dynamics of Proteins. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.5b00664
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