The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Synthetic, Switchable Enzymes
Open accessAbstract
The construction of switchable, radiation-controlled, aptameric enzymes - “swenzymes” - is, in principle, feasible. We propose a strategy to make such catalysts from 2 (or more) aptamers each selected to bind specifically to one of the substrates in, for example, a 2-substrate reaction. Construction of a combinatorial library of candidate swenzymes entails selecting a set of a million aptamers that bind one substrate and a second set of a million aptamers that bind the second substrate; the aptamers in these sets are then linked pairwise by a linker, thus bringing together the substrates. In the presence of the substrates, some linked aptamer pairs catalyze the reaction when exposed to external energy in the form of a specific frequency of low-intensity, nonionizing electromagnetic or acoustic radiation. Such swenzymes are detected via a separate product-capturing aptamer that changes conformation on capturing the product; this altered conformation allows it (1) to bind to every potential swenzyme in its vicinity (thereby giving a higher probability of capture to the swenzymes that generate the product) and (2) to bind to a sequence on a magnetic bead (thereby permitting purification of the swenzyme plus product-capturing aptamer by precipitation). Attempts to implement the swenzyme strategy may help elucidate fundamental problems in enzyme catalysis.
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Dynamic Allostery: Linkers Are Not Merely Flexible
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Nonenzymatic synthesis of oligoadenylates on a polyuridylic acid template.
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Metadata
- Authors
- Norris, V., Krylov, S. N., Agarwal, P. K., & White, G. J.
- Venue
- Microbial Physiology
- Publisher
- S. Karger AG
- Published
- 2017
- Volume
- 27
- Issue
- 2
- Pages
- 117-127
- ISSN
- 2673-1665 (ISSN-L)
- 2673-1673
- OpenAlex
- W2609912642
- Cited by
- 632
- References
- 93
- FWCI
- 17.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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