The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Chalcone: A Privileged Structure in Medicinal Chemistry
Open accessAbstract
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.
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Cites
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Privileged scaffolds for library design and drug discovery
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Small Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents
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Redox signaling: an evolution from free radicals to aging
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Self-citationZhuang, C., Miao, Z., Wu, Y., Guo, Z., Li, J., Yao, J., Xing, C., Sheng, C., & Zhang, W. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401800k · Cited by 50
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Cited by
Rudrapal, M., Khairnar, S. J., Khan, J., Dukhyil, A. B., Ansari, M. A., Alomary, M. N., Alshabrmi, F. M., Palai, S., Deb, P. K., & Devi, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.806470 · Cited by 1,084
Chalcone synthesis, properties and medicinal applications: a review
Rammohan, A., Reddy, J. S., Sravya, G., Rao, C. N., & Zyryanov, G. V. (2020) · Environmental Chemistry Letters · doi:10.1007/s10311-019-00959-w · Cited by 389
Chalcones: Synthetic Chemistry Follows Where Nature Leads
Jasim, H. A., Nahar, L., Jasim, M. A., Moore, S. A., Ritchie, K. J., & Sarker, S. D. (2021) · Biomolecules · doi:10.3390/biom11081203 · Cited by 167
Zou, D., Liu, R., Lv, Y., Guo, J., Zhang, C., & Xie, Y. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2270781 · Cited by 60
Metadata
- Authors
- Zhuang, C., Zhang, W., Sheng, C., Zhang, W., Xing, C., & Miao, Z.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-05-10
- Volume
- 117
- Issue
- 12
- Pages
- 7762-7810
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2613820968
- Cited by
- 1,463
- References
- 8
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhuang, C., Zhang, W., Sheng, C., Zhang, W., Xing, C., & Miao, Z. (2017). Chalcone: A Privileged Structure in Medicinal Chemistry. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.7b00020
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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