Deep Dive into Plastic Monomers, Additives, and Processing Aids
Open accessAbstract
A variety of chemical substances used in plastic production may be released throughout the entire life cycle of the plastic, posing risks to human health, the environment, and recycling systems. Only a limited number of these substances have been widely studied. We systematically investigate plastic monomers, additives, and processing aids on the global market based on a review of 63 industrial, scientific, and regulatory data sources. In total, we identify more than 10'000 relevant substances and categorize them based on substance types, use patterns, and hazard classifications wherever possible. Over 2'400 substances are identified as substances of potential concern as they meet one or more of the persistence, bioaccumulation, and toxicity criteria in the European Union. Many of these substances are hardly studied according to SciFinder (266 substances), are not adequately regulated in many parts of the world (1'327 substances), or are even approved for use in food-contact plastics in some jurisdictions (901 substances). Substantial information gaps exist in the public domain, particularly on substance properties and use patterns. To transition to a sustainable circular plastic economy that avoids the use of hazardous chemicals, concerted efforts by all stakeholders are needed, starting by increasing information accessibility.
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A large number of additives and monomers produced and traded in the global market have been identified as substances of potential concern for their toxicity based on European Union criteria.
“Yet, a large number of additives and monomers produced and traded in the global market have been identified as substances of potential concern for their toxicity based on the European Union criteria 48 .”
From Complexities of the global plastics supply chain revealed in a trade-linked material flow analysis (2025) · cites this paper as [48]
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Cites
Encyclopedia of polymer science and technology
(2003) · Choice Reviews Online · doi:10.5860/choice.41-0674 · Cited by 5,100 · see citing works
Hahladakis, J. N., Velis, C. A., Weber, R., Iacovidou, E., & Purnell, P. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2017.10.014 · Cited by 3,873 · see citing works
Ullmann's Encyclopedia of Industrial Chemistry
(2012) · Choice Reviews Online · doi:10.5860/choice.50-1224 · Cited by 3,067 · see citing works
International Agency for Research on Cancer (IARC)
(2018) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-94186-5_629 · Cited by 2,796 · see citing works
Lithner, D., Larsson, Å., & Dave, G. (2011) · Science of The Total Environment · doi:10.1016/j.scitotenv.2011.04.038 · Cited by 2,684 · see citing works
Ullmann’s Encyclopedia of Industrial Chemistry
Gamble, A. (2019) · The Charleston Advisor · doi:10.5260/chara.20.4.46 · Cited by 1,417 · see citing works
Wang, Z., Walker, G. W., Muir, D. C. G., & Nagatani-Yoshida, K. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b06379 · Cited by 1,084 · see citing works
Self-citationRudel, R. A., Camann, D., Spengler, J. D., Korn, L. R., & Brody, J. G. (2003) · Environmental Science & Technology · doi:10.1021/es0264596 · Cited by 1,057 · see citing works
(1991) · Additives for Polymers · doi:10.1016/0306-3747(91)90486-6 · Cited by 935 · see citing works
Overview of known plastic packaging-associated chemicals and their hazards
Groh, K. J., Backhaus, T., Carney-Almroth, B., Geueke, B., Inostroza, P. A., Lennquist, A., Leslie, H. A., Maffini, M., Slunge, D., Trasande, L., et al. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.10.015 · Cited by 913 · see citing works
InChI, the IUPAC International Chemical Identifier
Heller, S. R., Mcnaught, A. D., Плетнев, И. В., Stein, S. E., & Tchekhovskoi, D. V. (2015) · Journal of Cheminformatics · doi:10.1186/s13321-015-0068-4 · Cited by 875 · see citing works
Phthalates and other additives in plastics: human exposure and associated health outcomes
Meeker, J. D., Sathyanarayana, S., & Swan, S. H. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0268 · Cited by 835 · see citing works
Nontarget Screening with High Resolution Mass Spectrometry in the Environment: Ready to Go?
Hollender, J., Schymanski, E., Singer, H., & Ferguson, P. L. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02184 · Cited by 743 · see citing works
Schymanski, E., Singer, H., Slobodnı́k, J., Ipolyi, I. M., Oswald, P., Krauss, M. K. V., Schulze, T., Haglund, P. S., Letzel, T., Grosse, S., et al. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-8681-7 · Cited by 709 · see citing works
Geueke, B., Groh, K. J., & Muncke, J. (2018) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2018.05.005 · Cited by 686 · see citing works
Human body burdens of chemicals used in plastic manufacture
Koch, H. M., & Calafat, A. M. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0208 · Cited by 609 · see citing works
OECD Guidelines for Testing of Chemicals
Maibach, H. I., & Wilhelm, K. (2007) · Informa Healthcare eBooks · doi:10.1201/9781420009774.ch33 · Cited by 506 · see citing works
Leaching of plastic additives to marine organisms
Koelmans, A. A., Besseling, E., & Foekema, E. M. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2013.12.013 · Cited by 501 · see citing works
Machine learning methods in chemoinformatics
Mitchell, J. B. O. (2014) · Wiley Interdisciplinary Reviews Computational Molecular Science · doi:10.1002/wcms.1183 · Cited by 470 · see citing works
Benchmarking the in Vitro Toxicity and Chemical Composition of Plastic Consumer Products
Zimmermann, L., Dierkes, G., Ternes, T. A., Völker, C., & Wagner, M. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b02293 · Cited by 438 · see citing works
Lucattini, L., Poma, G., Covaci, A., de Boer, J., Lamoree, M. H., & Leonards, P. E. G. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.02.161 · Cited by 362 · see citing works
Nerı́n, C., Alfaro, P., Aznar, M., & Domeño, C. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.02.028 · Cited by 347 · see citing works
The handbook of environmental chemistry
Negm, A. M., & Abd‐Elaty, I. (2019) · Springer eBooks · Cited by 277 · see citing works
Machine Learning Methods for Property Prediction in Chemoinformatics:Quo Vadis?
Varnek, A. A., & Baskin, I. I. (2012) · Journal of Chemical Information and Modeling · doi:10.1021/ci200409x · Cited by 245 · see citing works
He, Z., Li, G., Chen, J., Huang, Y. P., An, T., & Zhang, C. (2015) · Environment International · doi:10.1016/j.envint.2015.01.004 · Cited by 237 · see citing works
Probabilistic Material Flow Analysis of Seven Commodity Plastics in Europe
Kawecki, D., Scheeder, P. R. W., & Nowack, B. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b01513 · Cited by 232 · see citing works
Wagner, S., & Schlummer, M. (2020) · Resources Conservation and Recycling · doi:10.1016/j.resconrec.2020.104800 · Cited by 231 · see citing works
Black plastics: Linear and circular economies, hazardous additives and marine pollution
Turner, A. (2018) · Environment International · doi:10.1016/j.envint.2018.04.036 · Cited by 222 · see citing works
Contamination in plastic recycling: influence of metals on the quality of reprocessed plastic
Eriksen, M. K., Pivnenko, K., Olsson, M. E., & Astrup, T. F. (2018) · Waste Management · doi:10.1016/j.wasman.2018.08.007 · Cited by 201 · see citing works
Non-intentionally added substances (NIAS) in recycled plastics
Horodytska, O., Cabanes, A., & Fullana, A. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126373 · Cited by 170 · see citing works
Overview of intentionally used food contact chemicals and their hazards
Groh, K. J., Geueke, B., Martin, O., Maffini, M. V., & Muncke, J. (2020) · Environment International · doi:10.1016/j.envint.2020.106225 · Cited by 163 · see citing works
Tang, Z., Zhang, L., Huang, Q., Yang, Y., Nie, Z., Cheng, J., Yang, J., Wang, Y., & Chai, M. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2015.08.006 · Cited by 156 · see citing works
Toward substitution with no regrets
Zimmerman, J. B., & Anastas, P. T. (2015) · Science · doi:10.1126/science.aaa0812 · Cited by 141 · see citing works
Exploring consumer exposure pathways and patterns of use for chemicals in the environment
Dionisio, K. L., Frame, A. M., Goldsmith, M., Wambaugh, J. F., Liddell, A. C., Cathey, T., Smith, D., Vail, J., Ernstoff, A. S., Fantke, P., et al. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2014.12.009 · Cited by 137 · see citing works
Risk assessment of chemicals: an introduction
Power, M. J., & Lanno, R. P. (1997) · Aquatic Toxicology · doi:10.1016/s0166-445x(96)00829-6 · Cited by 134 · see citing works
Propelling plastics into the circular economy — weeding out the toxics first
Leslie, H. A., Leonards, P. E. G., Brandsma, S. H., de Boer, J., & Jonkers, N. (2016) · Environment International · doi:10.1016/j.envint.2016.05.012 · Cited by 132 · see citing works
Jacobs, M., Malloy, T. F., Tickner, J. A., & Edwards, S. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409581 · Cited by 121 · see citing works
Vera, P., Canellas, E., & Nerı́n, C. (2018) · Talanta · doi:10.1016/j.talanta.2018.06.022 · Cited by 112 · see citing works
Degradation of contaminated plastics: a kinetic study
Day, M., Cooney, J. D., & MacKinnon, M. (1995) · Polymer Degradation and Stability · doi:10.1016/0141-3910(95)00088-4 · Cited by 111 · see citing works
Indirect Food Additives and Polymers
Sheftel, V. O. (2000) · CRC Press eBooks · doi:10.1201/9781482293821 · Cited by 104 · see citing works
Bueno, M. J. M., Gómez, M. J., Bauer, A., & Fernández‐Alba, A. R. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.10.035 · Cited by 92 · see citing works
Handbook for the Chemical Analysis of Plastic and Polymer Additives
Bolgar, M., Hubball, J., Groeger, J., et al. (2015) · CRC Press eBooks · doi:10.1201/b19124 · Cited by 82 · see citing works
Characterizing Airborne Phthalate Concentrations and Dynamics in a Normally Occupied Residence
Lunderberg, D. M., Kristensen, K. V., Liu, Y. J., Misztal, P. K., Tian, Y., Arata, C. M., Wernis, R. A., Kreisberg, N. M., Nazaroff, W. W., & Goldstein, A. H. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b02123 · Cited by 78 · see citing works
Dijk, J. V., Gustavsson, M. B., Dekker, S. C., et al. (2020) · Journal of Environmental Management · doi:10.1016/j.jenvman.2020.111692 · Cited by 76 · see citing works
Open Science for Identifying “Known Unknown” Chemicals
Schymanski, E., & Williams, A. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b01908 · Cited by 71 · see citing works
Onghena, M., Hoeck, E. V., Vervliet, P., Scippo, M. L., Simon, C., Loco, J. V., & Covaci, A. (2014) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2014.979372 · Cited by 64 · see citing works
Tang, Z., Huang, Q., Yang, Y., Nie, Z., Cheng, J., Yang, J., Wang, Y., & Chai, M. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-5296-7 · Cited by 63 · see citing works
Environmental and health hazards of chemicals in plastic polymers and products
Lithner, D. (2011) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 62 · see citing works
Rugard, M., Coumoul, X., Carvaillo, J.-C., Barouki, R., & Audouze, K. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz214 · Cited by 62 · see citing works
Exploring regrettable substitution: replacements for bisphenol A
Trasande, L. (2017) · The Lancet Planetary Health · doi:10.1016/s2542-5196(17)30046-3 · Cited by 61 · see citing works
Hazardous substances in plastics
Stenmarck, Å., Belleza, E. L., Fråne, A., Busch, N., Larsen, Å., & Wahlström, M. (2017) · TemaNord · doi:10.6027/tn2017-505 · Cited by 60 · see citing works
Wang, Z., & Hellweg, S. (2021) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.1c00243 · Cited by 59 · see citing works
Self-citationKunststoffchemie für Ingenieure
Kaiser, W. (2011) · Carl Hanser Verlag GmbH & Co. KG eBooks · doi:10.3139/9783446430495 · Cited by 56 · see citing works
Should the Model for Risk‐Informed Regulation be Game Theory Rather than Decision Theory?
Bier, V. M., & Lin, S. (2012) · Risk Analysis · doi:10.1111/j.1539-6924.2012.01866.x · Cited by 52 · see citing works
A Concise Introduction to Additives for Thermoplastic Polymers
Fink, J. K. (2009) · Wiley eBooks · doi:10.1002/9780470624241 · Cited by 38 · see citing works
Pollution havens and the trade in toxic chemicals: Evidence from U.S. trade flows
Tang, J. P. (2015) · Ecological Economics · doi:10.1016/j.ecolecon.2015.02.022 · Cited by 33 · see citing works
Simpson, S., Adams, N., Brugman, C., & Conners, T. J. (2018) · JMIR Public Health and Surveillance · doi:10.2196/publichealth.7726 · Cited by 31 · see citing works
Baur, E., Osswald, T. A., & Rudolph, N. M. (2018) · Carl Hanser Verlag GmbH & Co. KG eBooks · doi:10.3139/9781569905609 · Cited by 25 · see citing works
Importance of Data Curation in QSAR Studies Especially While Modeling Large-Size Datasets
Ambure, P. S., & Cordeiro, M. N. D. S. (2020) · Methods in pharmacology and toxicology · doi:10.1007/978-1-0716-0150-1_5 · Cited by 22 · see citing works
Slunge, D., & Alpízar, F. (2019) · Sustainability · doi:10.3390/su11164344 · Cited by 19 · see citing works
Bolinius, D. J., Sobek, A., Löf, M. F., & Undeman, E. (2018) · Environmental Science Processes & Impacts · doi:10.1039/c8em00270c · Cited by 16 · see citing works
Self-Policing in a Targeted Enforcement Regime
Stafford, S. L. (2008) · Southern Economic Journal · doi:10.2307/20112008 · Cited by 13 · see citing works
Guidance on Key Considerations for the Identification and Selection of Safer Chemical Alternatives
OECD (2021) · OECD series on risk management of chemicals. · doi:10.1787/a1309425-en · Cited by 10 · see citing works
Strategic Approach to International Chemicals Management (SAICM)
van der Kolk, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00606-0 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Andrews, S. M. Additives. Encyclopedia of Polymer Science and Technology; Wiley, 2010.
Cited by
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Complexities of the global plastics supply chain revealed in a trade-linked material flow analysis
Houssini, K., Li, J., & Tan, Q. (2025) · Communications Earth & Environment · doi:10.1038/s43247-025-02169-5 · Cited by 363 · see citing works
Digital product passports as enabler of the circular economy
Walden, J., Steinbrecher, A., & Marinkovic, M. (2021) · Chemie Ingenieur Technik · doi:10.1002/cite.202100121 · Cited by 252 · see citing works
Untangling the chemical complexity of plastics to improve life cycle outcomes
Law, K. L., Sobkowicz, M. J., Shaver, M. P., & Hahn, M. E. (2024) · Nature Reviews Materials · doi:10.1038/s41578-024-00705-x · Cited by 78 · see citing works
Durkin, A. M., Zou, R., Boucher, J. M., Boyles, M. S., van Boxel, J., Bustamante, M., Christopher, E. A., Dadvand, P., Dusza, H. M., van Duursen, M., et al. (2024) · JMIR Research Protocols · doi:10.2196/63176 · Cited by 18 · see citing works
“Recent inventories document more than 4000 substances used in plastic packaging and more than 10,000 plastic-associated compounds, including organic polymers, additives such as plasticizers, and nonintentionally added substances such as reaction by-products [13,14].”
BackgroundSenevirathne, G. I., Gimhani, T. D. M., Reay, M. K., Perera, C., Ariyaratna, M., Karunarathna, A. K., Chadwick, D. R., Jones, D. L., Emrah, C., Lloyd, C. E. M., et al. (2025) · Environmental Advances · doi:10.1016/j.envadv.2025.100628 · Cited by 8 · see citing works
Persistent, mobile, and toxic plastic additives in Canada: properties and prioritization
Fries, E. C., Grewal, T., & Suehring, R. (2023) · doi:10.32920/21950690 · Cited by 2 · see citing works
- Authors
- Wiesinger, H., Wang, Z., & Hellweg, S.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Wiesinger, Helene
- Wang, Zhanyun
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-06-22
- Volume
- 55
- Issue
- 13
- Pages
- 9339-9351
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W3176745748
- Cited by
- 724
- References
- 65
- Citations by year
- 2026: 155 · 2025: 178 · 2024: 152 · 2023: 112 · 2022: 101 · 2021: 26
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
- Locations
- Environmental Science & Technology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Repository for Publications and Research Data (ETH Zurich) (acceptedVersion, public-domain)
- ETH Zürich Research Collection
- Funders
- Eidgen??ssische Technische Hochschule Z??rich
- Bundesamt f??r Umwelt (8T20/17.0103.PJ)
- Bundesamt f??r Gesundheit (18.000809)
- Canton of Zurich???s Office for Waste, Water, Energy and Air (85P-1454)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer Science and PVC
- Keywords
- plastic monomers, polymer additives, processing aids, chemical hazard assessment, substances of concern, persistent bioaccumulative toxic substances, chemical regulation, food contact plastics, information gap, circular plastic economy, plastic life cycle, plastic recycling
- MeSH terms
- European Union, Humans, Plastics, Hazardous Substances, Recycling
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