The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae
Abstract
Bisphenol A (BPA), a chemical incorporated into plastics and resins, has estrogenic activity and is associated with adverse health effects in humans and wildlife. Similarly structured BPA analogues are widely used but far less is known about their potential toxicity or estrogenic activity in vivo. We undertook the first comprehensive analysis on the toxicity and teratogenic effects of the bisphenols BPA, BPS, BPF, and BPAF in zebrafish embryo-larvae and an assessment on their estrogenic mechanisms in an estrogen-responsive transgenic fish Tg(ERE:Gal4ff)(UAS:GFP). The rank order for toxicity was BPAF > BPA > BPF > BPS. Developmental deformities for larval exposures included cardiac edema, spinal malformation, and craniofacial deformities and there were distinct differences in the effects and potencies between the different bisphenol chemicals. These effects, however, occurred only at concentrations between 1.0 and 200 mg/L which exceed those in most environments. All bisphenol compounds induced estrogenic responses in Tg(ERE:Gal4ff)(UAS:GFP) zebrafish that were inhibited by coexposure with ICI 182 780, demonstrating an estrogen receptor dependent mechanism. Target tissues included the heart, liver, somite muscle, fins, and corpuscles of Stannius. The rank order for estrogenicity was BPAF > BPA = BPF > BPS. Bioconcentration factors were 4.5, 17.8, 5.3, and 0.067 for exposure concentrations of 1.0, 1.0, 0.10, and 50 mg/L for BPA, BPF, BPAF, and BPS, respectively. We thus show that these BPA alternatives induce similar toxic and estrogenic effects to BPA and that BPAF is more potent than BPA, further highlighting health concerns regarding the use of BPA alternatives.
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Exposure of the U.S. Population to Bisphenol A and 4- tertiary -Octylphenol: 2003–2004
Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10753 · Cited by 1,743
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Occurrence of phthalates and bisphenol A and F in the environment
Fromme, H., Küchler, T., Otto, T., Pilz, K., Müller, J., & Wenzel, A. (2002) · Water Research · doi:10.1016/s0043-1354(01)00367-0 · Cited by 1,008
Sternberg (1983) · Computer · doi:10.1109/mc.1983.1654163 · Cited by 930
A critical analysis of the biological impacts of plasticizers on wildlife
Oehlmann, J., Schulte-Oehlmann, U., Kloas, W., Jagnytsch, O., Lutz, I., Kusk, K. O., Wollenberger, L., Santos, E. M., Paull, G. C., Van Look, K. J. W., et al. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0242 · Cited by 926
Self-citationBisphenol A exposure, effects, and policy: A wildlife perspective
Flint, S., Markle, T., Thompson, S., & Wallace, E. (2012) · Journal of Environmental Management · doi:10.1016/j.jenvman.2012.03.021 · Cited by 884
Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist
Moriyama, K., Tagami, T., Akamizu, T., Usui, T., Saijo, M., Kanamoto, N., Hataya, Y., Shimatsu, A., Kuzuya, H., & Nakao, K. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020209 · Cited by 812
Comparative Study of the Endocrine-Disrupting Activity of Bisphenol A and 19 Related Compounds
Kitamura, S. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi074 · Cited by 743
Liao, C., & Kannan, K. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400445n · Cited by 705
Cited by
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease
Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Beguinot, F., Formisano, P., & Oriente, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165761 · Cited by 478
Akhbarizadeh, R., Dobaradaran, S., Schmidt, T. C., Nabipour, I., & Spitz, J. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122271 · Cited by 271
Liu, X., Bian, Y., Zhao, J., Wang, Y., & Zhao, L. (2020) · Microchemical Journal · doi:10.1016/j.microc.2020.105438 · Cited by 51
Endocrine-disrupting chemicals exposure: Cardiometabolic health risk in humans
Ma, C.-X., Ma, X.-N., Li, H.-L., Mauricio, D., & Fu, S.-B. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02938-8 · Cited by 19
Dynamics of Endocrine Disruptor Exposure in Early Life: A Mother–Infant Hair Biomonitoring Study
Kalligiannaki, A., Baliou, S., Vakonaki, E., Panteris, E., Hatzidaki, E., & Tzatzarakis, M. (2026) · Toxics · doi:10.3390/toxics14020175 · Cited by 3
Metadata
- Authors
- Moreman, J., Lee, O., Trznadel, M., David, A., Kudoh, T., & Tyler, C. R.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-10-25
- Volume
- 51
- Issue
- 21
- Pages
- 12796-12805
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2763927309
- Cited by
- 527
- References
- 55
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae. https://app.cochat.ai/papers/10.1021/acs.est.7b03283
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- Moreman, J., Lee, O., Trznadel, M., David, A., Kudoh, T., & Tyler, C. R. (2017). Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae. Environmental Science & Technology. https://doi.org/10.1021/acs.est.7b03283
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