The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease
Open accessAbstract
Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, and dental materials. BPA can contaminate food, beverage, air, and soil. It accumulates in several human tissues and organs and is potentially harmful to human health through different molecular mechanisms. Due to its hormone-like properties, BPA may bind to estrogen receptors, thereby affecting both body weight and tumorigenesis. BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, and HAND2, are involved in BPA action on fat and liver homeostasis, the cardiovascular system, and cancer. Finally, epigenetic changes, such as DNA methylation, histones modification, and changes in microRNAs expression contribute to BPA pathological effects. This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.
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Cites
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Cited by
Suksatan, W., Moradi, S., Naeini, F., Bagheri, R., Mohammadi, H., Talebi, S., Mehrabani, S., Hojjati Kermani, M. A., & Suzuki, K. (2021) · Nutrients · doi:10.3390/nu14010174 · Cited by 133
The tumor microenvironment: shaping cancer progression and treatment response
Desai, S. A., Patel, V. P., Bhosle, K. P., Nagare, S. D., & Thombare, K. C. (2025) · Journal of Chemotherapy · doi:10.1080/1120009x.2023.2300224 · Cited by 106
Li, J., Yu, G., Wang, L., Zhang, W., Ke, W., Li, Y., Liu, D., Xie, K., Xu, Y., Cha, C., et al. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117427 · Cited by 10
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Metadata
- Authors
- Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Beguinot, F., Formisano, P., & Oriente, F.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-08-11
- Volume
- 21
- Issue
- 16
- Pages
- 5761
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3048777645
- Cited by
- 478
- References
- 165
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cimmino, I., Fiory, F., Perruolo, G., Miele, C., Beguinot, F., Formisano, P., & Oriente, F. (2020). Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21165761
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