c9, t11, c15-CLNA and t9, t11, c15-CLNA from Lactobacillus plantarum ZS2058 Ameliorate Dextran Sodium Sulfate-Induced Colitis in Mice
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To investigate the specific functions of conjugated fatty acids (CFAs) produced by the probiotic bacterium, α-linolenic acid was isomerized by Lactobacillus plantarum ZS2058, and two different conjugated linolenic acid (CLNA) isomers were successfully isolated: c9, t11, c15-CLNA (CLNA1) and t9, t11, c15-CLNA (CLNA2). The effects and mechanism of CLNA crude extract and individual isomers on colitis were explored. CLNA significantly inhibited weight loss, the disease activity index, and colon shortening. Additionally, CLNA alleviated histological damage, protected colonic mucus layer integrity, and significantly upregulated the concentration of tight junction proteins (ZO-1, occludin, E-cadherin 1, and claudin-3). CLNA significantly attenuated the level of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) while upregulating the expression of the colonic anti-inflammatory cytokine IL-10 and nuclear receptor peroxisome-activated receptor-γ. Moreover, CLNA increased the activity of oxidative stress-related enzymes (SOD, GSH, and CAT), and the myeloperoxidase activity was significantly decreased by CLNA. Meanwhile, the concentrations of CLNA in the liver and conjugated linoleic acid in the colonic content were significantly increased because of the treatment of CLNA. Furthermore, CLNA could rebalance the intestinal microbial composition of colitis mice, including increasing the α-diversity. CLNA1 and CLNA2 increased the abundance of Ruminococcus and Prevotella, respectively.
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CLNA1 and CLNA2 treatments rebalanced the intestinal microbial composition in the colons of DSS-treated mice, including increasing α-diversity.
“These treatments also rebalanced the intestinal microbial composition in the colons of DSS-treated mice, including increasing the α-diversity.121”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [121]
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Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
- Authors
- Ren, Q., Yang, B., Zhang, H., Ross, R. P., Stanton, C., Chen, H., & Chen, W.
- Affiliations
- Jiangnan University (CN)
- Corresponding author
- Chen, Haiqin
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-03-03
- Volume
- 68
- Issue
- 12
- Pages
- 3758-3769
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W3009195735
- Cited by
- 37
- References
- 56
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 9 · 2023: 7 · 2022: 1 · 2021: 7 · 2020: 2
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion)
- Funders
- Ministry of Education of the People's Republic of China (JUSRP11733, JUSRP51702A)
- Government of Jiangsu Province (KYCX18_1763)
- National Natural Science Foundation of China (31530056, 31722041, 31801521)
- National First-class Discipline Program of Food Science and Technology (JUFSTR20180102)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- conjugated linolenic acid, Lactobacillus plantarum, DSS-induced colitis, tight junction proteins, intestinal barrier, inflammatory cytokines, IL-10, PPARγ, oxidative stress, myeloperoxidase, gut microbiota, Ruminococcus, Prevotella, inflammatory bowel disease
- MeSH terms
- Animals, Colitis, Male, Mice, Inbred C57BL, Cytokines, Dextran Sulfate, Linoleic Acids, Conjugated, Lactiplantibacillus plantarum, Mice
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