The application of Ferroptosis in diseases

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

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Parkinson's disease

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Hepatocellular carcinoma

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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

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Glutathione Metabolism and Its Implications for Health

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

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Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

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Lung cancer: current therapies and new targeted treatments

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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[44] Glutathione peroxidase

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Targeting Ferroptosis to Iron Out Cancer

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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The role of iron and reactive oxygen species in cell death

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Autophagy promotes ferroptosis by degradation of ferritin

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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

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Breast cancer

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Acute Lymphoblastic Leukemia in Children

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Ferroptosis as a target for protection against cardiomyopathy

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Regulation of glutathione synthesis

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

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Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

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Drugging the undruggable RAS: Mission Possible?

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Glutathione peroxidases

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

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Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

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An overview of the immune system

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Hepcidin and iron homeostasis

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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

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Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

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Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

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Identification of ACSL4 as a biomarker and contributor of ferroptosis

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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

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Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

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[5] Diversity of glutathione peroxidases

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Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

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ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

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The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

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NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

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Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

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The Roles of NRF2 in Modulating Cellular Iron Homeostasis

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Emerging Strategies of Cancer Therapy Based on Ferroptosis

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Iron‐sulphur clusters and the problem with oxygen

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Metallothionein‐1G facilitates sorafenib resistance through inhibition of ferroptosis

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Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

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RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

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Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

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Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

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Inhibition of neuronal ferroptosis protects hemorrhagic brain

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The release and activity of HMGB1 in ferroptosis

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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

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Characterization of ferroptosis in murine models of hemochromatosis

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Ironing out Ferroportin

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Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis

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Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

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Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

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Integrative Molecular Characterization of Malignant Pleural Mesothelioma

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Tumor resistance to apoptosis

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Salinomycin kills cancer stem cells by sequestering iron in lysosomes

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Iron‐dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

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HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

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Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

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Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

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Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

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Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

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Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

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Programmed cell death and the immune system

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Lipid storage and lipophagy regulates ferroptosis

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A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53

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Iron, lipid peroxidation, and ferroptosis play pathogenic roles in atherosclerosis

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Targetting ferroptosis for blood cell-related diseases

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Ferroptosis as a new therapeutic opportunity for nonviral liver disease

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Inhibition of spinal ferroptosis-like cell death alleviates hyperalgesia and spontaneous pain in a mouse model of bone cancer pain

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Unraveling the Anticancer Potential of Statins: Mechanisms and Clinical Significance

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Ferroptosis: a new hunter of hepatocellular carcinoma

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Mechanism of Ferroptosis and Its Relationships With Other Types of Programmed Cell Death: Insights for Potential Interventions After Intracerebral Hemorrhage

Zhou, S., Cui, G., Yan, X., Wang, X., Qu, Y., Guo, Z., & Jin, H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.589042 · Cited by 59 · see citing works

CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma

Li, B., Wei, S., Yang, L., Peng, X., Ma, Y., Wu, B., Fan, Q., Yang, S., Li, X., Jin, H., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.657723 · Cited by 59 · see citing works

A tumor microenvironment responsive nanoplatform with oxidative stress amplification for effective MRI-based visual tumor ferroptosis

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New Insights into the Role of Ferroptosis in Cardiovascular Diseases

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Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

Zeng, L., Yang, K., Yu, G., Hao, W., Zhu, X., Ge, A., Chen, J., & Sun, L. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06807-2 · Cited by 62 · see citing works

Isoliquiritin apioside relieves intestinal ischemia/reperfusion-induced acute lung injury by blocking Hif-1α-mediated ferroptosis

Zhongyin, Z., Wang, W., Xiong, J., & Guohua, F. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108852 · Cited by 58 · see citing works

Ferroptosis due to Cystathionine γ Lyase/Hydrogen Sulfide Downregulation Under High Hydrostatic Pressure Exacerbates VSMC Dysfunction

Jin, R., Yang, R., Cui, C., Zhang, H., Cai, J., Geng, B., & Chen, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.829316 · Cited by 56 · see citing works

Ferroptosis and musculoskeletal diseases: “Iron Maiden” cell death may be a promising therapeutic target

Zhang, Y., Huang, X., Qi, B., Sun, C., Sun, K., Liu, N., Zhu, L., & Wei, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.972753 · Cited by 56 · see citing works

GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism

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TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice

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Drugs/agents for the treatment of ischemic stroke: Advances and perspectives

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Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis‐Induced Acute Lung Injury through GSK3 β /Keap1‐Nrf2‐GPX4 Pathway

Wang, Y., Gong, F., Qi, X., Zheng, Y., Zheng, X.-T., Chen, Y., Yang, Z., Qing-Ye, Mao, E., & Chen, E. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2405943 · Cited by 52 · see citing works

How zoledronic acid improves osteoporosis by acting on osteoclasts

Wang, B., Zhan, Y., Yan, L. W., & Hao, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.961941 · Cited by 52 · see citing works

Novel Near-Infrared Fluorescence Probe for Bioimaging and Evaluating Superoxide Anion Fluctuations in Ferroptosis-Mediated Epilepsy

Yang, W., Liu, R., Yin, X., Wu, K., Yan, Z., Wang, X., Fan, G., Tang, Z., Li, Y., & Jiang, H. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c00852 · Cited by 52 · see citing works

Targeting Ferroptosis to Treat Cardiovascular Diseases: A New Continent to Be Explored

Huang, F., Yang, R., Xiao, Z., Xie, Y., Lin, X., Zhu, P., Zhou, P., Lu, J., & Zheng, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.737971 · Cited by 52 · see citing works

Homogenous multifunctional microspheres induce ferroptosis to promote the anti-hepatocarcinoma effect of chemoembolization

Chen, M., Li, J., Shu, G., Shen, L., Qiao, E., Zhang, N., Fang, S., Chen, X., Zhao, Z., Tu, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01385-x · Cited by 52 · see citing works

Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR‐3200‐5p/ATF4 Axis

Guan, L., Wang, F., Wang, M., Han, S., Cui, Z., Xi, S., Xu, H., & Li, S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9613095 · Cited by 50 · see citing works

Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo

Chen, H., Cao, L., Han, K., Zhang, H., Cui, J., Ma, X., Zhao, S., Zhao, C., Yin, S., Fan, L., et al. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113255 · Cited by 49 · see citing works

Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway

Liu, Z., Zhou, Z., Ai, P., Zhang, C., Chen, J., & Wang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.924826 · Cited by 50 · see citing works

Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP+-induced models of Parkinson’s disease

Liu, T., Wang, P., Yin, H., Wang, X., Lv, J., Jiang, Y., Zhu, J. F., & Wang, Y. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371381 · Cited by 50 · see citing works

p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model

Feng, L., Wang, C., Zhang, C., Zhang, W., Zhu, W., He, Y., Xia, Z., & Song, W. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.391193 · Cited by 50 · see citing works

Ferroptosis interaction with inflammatory microenvironments: Mechanism, biology, and treatment

Dou, J., Liu, X., Yang, L., Huang, D., & Tan, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113711 · Cited by 49 · see citing works

The Role of Iron Metabolism, Lipid Metabolism, and Redox Homeostasis in Alzheimer’s Disease: from the Perspective of Ferroptosis

Wu, L., Xian, X., Tan, Z., Dong, F., Xu, G., Zhang, M., & Zhang, F. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03245-7 · Cited by 49 · see citing works

Galangin inhibited ferroptosis through activation of the PI3K / AKT pathway in vitro and in vivo

Chen, K., Xue, R., Geng, Y., & Zhang, S. (2022) · The FASEB Journal · doi:10.1096/fj.202200935r · Cited by 46 · see citing works

Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing

Song, J., Zhu, K., Wang, H., Wu, M., Wu, Y., & Zhang, Q. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.88461 · Cited by 45 · see citing works

Role of Ferroptosis in Regulating the Epithelial–Mesenchymal Transition in Pulmonary Fibrosis

Ling, H., Xiao, H., Luo, T. L., Lin, H., & Deng, J. (2023) · Biomedicines · doi:10.3390/biomedicines11010163 · Cited by 42 · see citing works

Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity

Ahmed, D. S., Isnard, S., Berini, C. A., Lin, J. C.-Y., Routy, J., & Royston, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.820350 · Cited by 44 · see citing works

Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer

Liu, L., Li, L., Li, M., & Luo, Z. Y. (2021) · ChemMedChem · doi:10.1002/cmdc.202100334 · Cited by 43 · see citing works

Ferroptosis exacerbates hyperlipidemic acute pancreatitis by enhancing lipid peroxidation and modulating the immune microenvironment

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Mechanisms and inhibitors of ferroptosis in psoriasis

Zhou, Q., Yang, L., Li, T., Wang, K., Huang, X., Shi, J., & Wang, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1019447 · Cited by 42 · see citing works

Expression pattern and diagnostic value of ferroptosis-related genes in acute myocardial infarction

Wu, J., Cai, H., Lei, Z., Li, C., Hu, Y., Zhang, T., Zhu, H., Lu, Y., Cao, J., & Hu, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.993592 · Cited by 41 · see citing works

The emerging roles of ferroptosis in organ fibrosis and its potential therapeutic effect

Huang, X., Song, Y., Wei, L., Guo, J., Xu, W., & Li, M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109812 · Cited by 41 · see citing works

Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD

Yue, F., Shi, Y., Wu, S., Lin, X., He, D., Lin, W., Qiu, A., Russell, R., & Zhang, D. (2023) · iScience · doi:10.1016/j.isci.2023.108560 · Cited by 43 · see citing works

Entacapone alleviates acute kidney injury by inhibiting ferroptosis

Yang, J., Sun, X., Huang, N., Li, P., He, J., Jiang, L., Zhang, X., Han, S., & Xin, H. (2022) · The FASEB Journal · doi:10.1096/fj.202200241rr · Cited by 40 · see citing works

Circular RNA circACAP2 Suppresses Ferroptosis of Cervical Cancer during Malignant Progression by miR-193a-5p/GPX4

Liu, Y., Li, L., Yang, Z., Wen, D., & Hu, Z. (2022) · Journal of Oncology · doi:10.1155/2022/5228874 · Cited by 41 · see citing works

IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis

Li, B., Wang, C., Lü, P., Ji, Y., Wang, X., Liu, C., Lu, X., Xu, X., & Wang, X. (2022) · Biology · doi:10.3390/biology11101392 · Cited by 40 · see citing works

Identification of key ferroptosis genes in diabetic retinopathy based on bioinformatics analysis

Huang, Y., Peng, J., & Liang, Q.-H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280548 · Cited by 40 · see citing works

Emerging Mechanisms and Targeted Therapy of Ferroptosis in Neurological Diseases and Neuro-oncology

Wang, Y., Tang, B., Zhu, J., Yu, J., Hui, J., Xia, S., & Ji, J. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72251 · Cited by 68 · see citing works

Ferroptosis: Newly Emerged Regulator for Human Disease

Xiao, D., Ye, L., Jiang, T., Liu, M., & Zhou, Y. (2026) · MedComm · doi:10.1002/mco2.70921 · Cited by 1 · see citing works

Ferroptosis: Mechanisms and links with diseases

Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471 · see citing works

Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases

Lv, Y., Wu, M., Wang, Z., & Wang, J. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09778-2 · Cited by 83 · see citing works

Zooming in and out of ferroptosis in human disease

Wang, X., Zhou, Y., Min, J., & Wang, F. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-0992-z · Cited by 83 · see citing works