Cited by 120Essential Oils and Antimicrobial ActivityPhytochemicals and Antioxidant ActivitiesFree Radicals and Antioxidants

Biological and Nonbiological Antioxidant Activity of Some Essential Oils

Pérez-Rosés, Renato, Risco, Ester, Vila, Roser, Peñalver, Pedro, Cañigueral, Salvador·2016·Journal of Agricultural and Food Chemistry

Abstract

Fifteen essential oils, four essential oil fractions, and three pure compounds (thymol, carvacrol, and eugenol), characterized by gas chromatography and gas chromatography-mass spectrometry, were investigated for biological and nonbiological antioxidant activity. Clove oil and eugenol showed strong DPPH (2,2-diphenyl-1-picrylhydrazyl) free-radical scavenging activity (IC50 = 13.2 μg/mL and 11.7 μg/mL, respectively) and powerfully inhibited reactive oxygen species (ROS) production in human neutrophils stimulated by PMA (phorbol 12-myristate 13-acetate) (IC50 = 7.5 μg/mL and 1.6 μg/mL) or H2O2 (IC50 = 22.6 μg/mL and 27.1 μg/mL). Nutmeg, ginger, and palmarosa oils were also highly active on this test. Essential oils from clove and ginger, as well as eugenol, carvacrol, and bornyl acetate inhibited NO (nitric oxide) production (IC50 < 50.0 μg/mL). The oils of clove, red thyme, and Spanish oregano, together with eugenol, thymol, and carvacrol showed the highest myeloperoxidase inhibitory activity. Isomers carvacrol and thymol displayed a disparate behavior in some tests. All in all, clove oil and eugenol offered the best antioxidant profile.

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Crossref · 10.1021/acs.jafc.6b00986

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Authors
Pérez-Rosés, R., Risco, E., Vila, R., Peñalver, P., & Cañigueral, S.
Affiliations
  • Universitat de Barcelona (ES)
  • Lidervet, S.L., Plaça García Lorca, 17, Baixos, E-43006 Tarragona, Spain
Corresponding author
Cañigueral, Salvador
Venue
Journal of Agricultural and Food Chemistry
Published
2016-06-02
Volume
64
Issue
23
Pages
4716-4724
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W2406889296
Cited by
120
References
45
Citations by year
2026: 7 · 2025: 8 · 2024: 13 · 2023: 18 · 2022: 22 · 2021: 15 · 2020: 14 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 1
FWCI
9.65
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Generalitat de Catalunya
  • European Social Fund
  • Lidervet S.L. (303524)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords
essential oils, antioxidant activity, DPPH radical scavenging, reactive oxygen species inhibition, nitric oxide production, myeloperoxidase inhibition, thymol, carvacrol, eugenol, clove oil, nutmeg oil, ginger essential oil, palmarosa oil, phorbol myristate acetate, hydrogen peroxide
MeSH terms
Antioxidants, Drug Evaluation, Preclinical, Humans, Leukocytes, Nitric Oxide, Oils, Volatile, Reactive Oxygen Species

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