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The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer

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Exploring the Pyrazinamide Drug Resistance Mechanism of Clinical Mutants T370P and W403G in Ribosomal Protein S1 of Mycobacterium tuberculosis

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Exploring the reason for increased activity of SHP2 caused by D61Y mutation through molecular dynamics

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Recent advance on PTP1B inhibitors and their biomedical applications

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A molecular docking and molecular dynamics simulation study on the interaction between cyanidin ‐ 3 ‐O ‐glucoside and major proteins in cow's milk

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Protective effect and mechanism of action of xanthan gum on the color stability of black rice anthocyanins in model beverage systems

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Xanthine oxidase inhibitory study of eight structurally diverse phenolic compounds

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Molecular dynamics simulation of zika virus NS5 RNA dependent RNA polymerase with selected novel non-nucleoside inhibitors

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Mechanism of zinc ejection by disulfiram in nonstructural protein 5A

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Laboratory Evolution of GH11 Endoxylanase Through DNA Shuffling: Effects of Distal Residue Substitution on Catalytic Activity and Active Site Architecture

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Novel N‐Acyl‐1H‐imidazole‐1‐carbothioamides: Design, Synthesis, Biological and Computational Studies

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Decoding allosteric communication pathways in protein lysine acetyltransferase

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Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

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Predicting Multi-Interfacial Binding Mechanisms of NLRP3 and ASC Pyrin Domains in Inflammasome Activation

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Dihydroquinazolin-4(1H)-one derivatives as novel and potential leads for diabetic management

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Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation

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Activating Mutation of SHP2 Establishes a Tumorigenic Phonotype Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms

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Molecular Insights into the Role of Pathogenic nsSNPs in GRIN2B Gene Provoking Neurodevelopmental Disorders

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Strategy for Leukemia Treatment Targeting SHP-1,2 and SHIP

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Synthesis of Spiro‐oxindole Analogs Engrafted Pyrazole Scaffold as Potential Alzheimer's Disease Therapeutics: Anti‐oxidant, Enzyme Inhibitory and Molecular Docking Approaches

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Unraveling the Cryoprotective Molecular Mechanisms of Antifreeze Peptides: New Insights from Simultaneous Interactions with Ice Crystals and Lactalbumin Proteins

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Structure‐based discovery of Licoflavone B and Ginkgetin targeting c‐Myc G‐quadruplex to suppress c‐Myc transcription and myeloma growth

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Computational screening and analysis of deleterious nsSNPs in human p14ARF (CDKN2A gene) protein using molecular dynamic simulation approach

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Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K

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Synthesis of indole derivatives as Alzheimer inhibitors and their molecular docking study

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Biology-oriented drug synthesis of nitrofurazone derivatives: Their α-glucosidase inhibitory activity and molecular docking studies

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Transcriptome Reveals the Key Genes Related to the Metabolism of Volatile Sulfur-Containing Compounds in Lentinula edodes Mycelium

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Enhancement of Thermostability and Catalytic Activity of β-1,4-Xylanase via Rational and Semi-rational Collaborative Engineering

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Clinical characteristics and prognostic analysis of acute myeloid leukemia patients with PTPN11 mutations

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Setting sail: Maneuvering SHP2 activity and its effects in cancer

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ATPR induces acute promyelocytic leukemia cells differentiation and growth arrest by blockade of SHP2/Rho/ROCK1 pathway

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Site-directed mutagenesis of family GH10 Aspergillus fumigatus xylanase A and the interaction with Oryza sativa xylanase inhibitor protein

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Investigation on potential allergenic peptides and critical amino acids of the digestive products of glycated α-lactalbumin via allergenicity evaluation and molecular dynamic simulation

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Validation of catalytic site residues of Ubiquitin Specific Protease 2 (USP2) by molecular dynamic simulation and novel kinetics assay for rational drug design

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Study on the allosteric activation mechanism of SHP2 via elastic network models and neural relational inference molecular dynamics simulation

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Competitive inhibition of family GH5 Aspergillus niger endo-glucanase A (AnglA5) by rice xylanase inhibitor (RIXI): Experimental and in silico insights

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Potential enzyme inhibitor triazoles from aliphatic esters: Synthesis, enzyme inhibition and docking studies

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BindingDB Entry 50018215: Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.

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Exploring the effect of E76K mutation on SHP2 cause gain‐of‐function activity by a molecular dynamics study

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Biochemical Dissection of SHP-2 and C-CBL in Juvenile Myelomonocytic Leukemia

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Shp2 regulates leukemic stem cell frequency in MLL-rearranged acute myeloid leukemia.

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R39: Impact des mutations de PTPN11 (SHP2) responsables du syndrome LEOPARD sur la signalisation PI3K/Akt/GSK-3beta induite par l’epidermal growth factor (EGF) : implication dans la tumorogenèse ?

Nédélec, A., Édouard, T., Combier, J., Bel-Vialar, S., Metrich, M., Conte-Auriol, F., Lyonnet, S., Parfait, B., Tauber, M., Salles, J., et al. (2010) · Bulletin du Cancer · doi:10.1016/s0007-4551(15)30956-5

Mechanism of Oncogenesis by Leukemia-Associated Mutants of Shp2 (PTPN11).

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