In Vitro and In Vivo Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin
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Abstract Curcumin-loaded polymeric micelles composed of poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared to solubilize and improve the pharmacokinetics of curcumin. Curcumin-loaded micelles were prepared by a nanoprecipitation method using mPEG5kDa-b-p(HPMA-Bz) copolymers with varying molecular weight of the hydrophobic block (5.2, 10.0, and 17.1 kDa). At equal curcumin loading, micelles composed of mPEG5kDa-b-p(HPMA-Bz)17.1kDa showed better curcumin retention in both phosphate-buffered saline (PBS) and plasma at 37 °C than micelles based on block copolymers with smaller hydrophobic blocks. No change in micelle size was observed during 24 h incubation in plasma using asymmetrical flow field-flow fractionation (AF4), attesting to particle stability. However, 22–49% of the curcumin loading was released from the micelles during 24 h from formulations with the highest to the lowest molecular weight p(HPMA-Bz), respectively, in plasma. AF4 analysis further showed that the released curcumin was subsequently solubilized by albumin. In vitro analyses revealed that the curcumin-loaded mPEG5kDa-b-p(HPMA-Bz)17.1kDa micelles were internalized by different types of cancer cells, resulting in curcumin-induced cell death. Intravenously administered curcumin-loaded, Cy7-labeled mPEG5kDa-b-p(HPMA-Bz)17.1kDa micelles in mice at 50 mg curcumin/kg showed a long circulation half-life for the micelles (t1/2 = 42 h), in line with the AF4 results. In contrast, the circulation time of curcumin was considerably shorter than that of the micelles (t1/2α = 0.11, t1/2β = 2.5 h) but ∼5 times longer than has been reported for free curcumin (t1/2α = 0.02 h). The faster clearance of curcumin in vivo compared to in vitro studies can be attributed to the interaction of curcumin with blood cells. Despite the excellent solubilizing effect of these micelles, no cytostatic effect was achieved in neuroblastoma-bearing mice, possibly because of the low sensitivity of the Neuro2A cells to curcumin.
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Cites
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543 · see citing works
DLS and zeta potential – What they are and what they are not?
Bhattacharjee, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.017 · Cited by 4,702 · see citing works
Sulforhodamine B colorimetric assay for cytotoxicity screening
Vichai, V., & Kirtikara, K. (2006) · Nature Protocols · doi:10.1038/nprot.2006.179 · Cited by 3,679 · see citing works
Fang, J. Q., Nakamura, H., & Maeda, H. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.04.009 · Cited by 3,573 · see citing works
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date
Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586 · see citing works
PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
Zhang, Y., Huo, M., Zhou, J., & Xie, S. (2010) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2010.01.007 · Cited by 2,073 · see citing works
Dynamic light scattering: a practical guide and applications in biomedical sciences
Stetefeld, J., McKenna, S. A., & Patel, T. R. (2016) · Biophysical Reviews · doi:10.1007/s12551-016-0218-6 · Cited by 2,058 · see citing works
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
WICKI, A. N., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.030 · Cited by 1,912 · see citing works
Block copolymer micelles in nanomedicine applications
Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309 · see citing works
Naksuriya, O., Okonogi, S., Schiffelers, R. M., & Hennink, W. E. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.090 · Cited by 844 · see citing works
Self-citationIn vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy
Kim, S. C., Kim, D. W., Shim, Y. H., Bang, J. S., Oh, H. S., Kim, S. W., & Seo, M. H. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00275-9 · Cited by 734 · see citing works
Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects
Vareed, S. K., Kakarala, M., Ruffin, M. T., Crowell, J. A., Normolle, D. P., Djurić, Z., & Brenner, D. E. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2693 · Cited by 586 · see citing works
Heger, M., van Golen, R. F., Broekgaarden, M., & Michel, M. C. (2013) · Pharmacological Reviews · doi:10.1124/pr.110.004044 · Cited by 581 · see citing works
Self-citationThe Multifaceted Role of Curcumin in Cancer Prevention and Treatment
Shanmugam, M. K., Rane, G., Kanchi, M. M., Arfuso, F., Chinnathambi, A., Zayed, M. E., Alharbi, S. A., Tan, B. K. H., Kumar, A. P., & Sethi, G. (2015) · Molecules · doi:10.3390/molecules20022728 · Cited by 522 · see citing works
Applications of π-π stacking interactions in the design of drug-delivery systems
Zhuang, W., Wang, Y., Cui, P., Xing, L., Lee, J., Kim, D., Jiang, H., & Oh, Y. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.014 · Cited by 513 · see citing works
Sparreboom, A., Scripture, C. D., Trieu, V. N., Williams, P. J., De, T., Yang, A. J., Beals, B., Figg, W. D., Hawkins, M., & Desai, N. P. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2291 · Cited by 506 · see citing works
Degradation of Curcumin: From Mechanism to Biological Implications
Schneider, C. G., Gordon, O. N., Edwards, R. L., & Luis, P. B. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00244 · Cited by 445 · see citing works
Seymour, L. W., Duncan, R., Strohalm, J., & Kopeček, J. (1987) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820211106 · Cited by 436 · see citing works
Molecular targets of phytochemicals for cancer prevention
Lee, K. W., Bode, A. M., & Dong, Z. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3017 · Cited by 427 · see citing works
Song, Z., Feng, R., Sun, M. H., Guo, C., Gao, Y., Li, L., & Zhai, G. (2010) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2010.10.024 · Cited by 340 · see citing works
Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma
Dhule, S. S., Penfornis, P., Frazier, T. P., Walker, R., Feldman, J., Tan, G., He, J., Alb, A. M., John, V. T., & Pochampally, R. R. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.07.011 · Cited by 299 · see citing works
Hydrotropic polymer micelle system for delivery of paclitaxel
Huh, K. M., Lee, S. C., Cho, Y. W., Lee, J., Jeong, J. H., & Park, K. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.003 · Cited by 291 · see citing works
Perspectives on the past, present, and future of cancer nanomedicine
Youn, Y. S., & Bae, Y. H. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.05.008 · Cited by 288 · see citing works
Bennion, B. J., Be, N. A., McNerney, M. W., Lao, V., Carlson, E. M., Valdez, C. A., Malfatti, M. A., Enright, H. A., Nguyen, T. H., Lightstone, F. C., et al. (2017) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.7b02914 · Cited by 284 · see citing works
Sun, J., Bi, C., Chan, H. M., Sun, S., Zhang, Q., & Zheng, Y. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.06.032 · Cited by 277 · see citing works
A Review of <i>In Vitro</i> Drug Release Test Methods for Nano-Sized Dosage Forms
D’Souza, S. (2014) · Advances in Pharmaceutics · doi:10.1155/2014/304757 · Cited by 262 · see citing works
Broekgaarden, M., Weijer, R., van Gulik, T. M., Hamblin, M. R., & Heger, M. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-015-9588-7 · Cited by 261 · see citing works
Self-citationRelease Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right?
Abouelmagd, S. A., Sun, B., Chang, A. C., Ku, Y. J., & Yeo, Y. (2015) · Molecular Pharmaceutics · doi:10.1021/mp500817h · Cited by 259 · see citing works
Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
Tan, B. L., & Norhaizan, M. E. (2019) · Molecules · doi:10.3390/molecules24142527 · Cited by 246 · see citing works
Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles
Gong, C., Deng, S., Wu, Q., Xiang, M., Wei, X., Li, L., Gao, X., Wang, B., Sun, L., Chen, Y., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.068 · Cited by 244 · see citing works
Inhibition of Proteasomal Function by Curcumin Induces Apoptosis through Mitochondrial Pathway
Jana, N. R., Dikshit, P., Goswami, A., & Nukina, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310369200 · Cited by 232 · see citing works
Fujisawa, S., Atsumi, T., Ishihara, M., & Kadoma, Y. (2004) · PubMed · Cited by 229 · see citing works
Shi, Y., van Steenbergen, M. J., Teunissen, E. A., Novo, L., Gradmann, S., Baldus, M., van Nostrum, C. F., & Hennink, W. E. (2013) · Biomacromolecules · doi:10.1021/bm400234c · Cited by 222 · see citing works
Self-citationShi, Y., van der Meel, R., Theek, B., Blenke, E. O., Pieters, E. H. E., Fens, M. H. A. M., Ehling, J., Schiffelers, R. M., Storm, G., van Nostrum, C. F., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b00929 · Cited by 215 · see citing works
Self-citationKnuth, A. K., Gabbert, H. E., Dippold, W. G., et al. (1985) · Journal of Hepatology · doi:10.1016/s0168-8278(85)80002-7 · Cited by 214 · see citing works
Blood volume determination in the mouse
Riches, A., Sharp, J. G., Thomas, D. B., & Smith, S. V. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010086 · Cited by 201 · see citing works
Polymeric micelles of biodegradable diblock copolymers: enhanced encapsulation of hydrophobic drugs
Hussein, Y. H. A., & Youssry, M. (2018) · Materials · doi:10.3390/ma11050688 · Cited by 196 · see citing works
Mehanny, M., Hathout, R. M., Geneidi, A. S., & Mansour, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.018 · Cited by 190 · see citing works
Duan, J., Zhang, Y., Han, S., Chen, Y., Li, B., Liao, M., Chen, W., Deng, X., Zhao, J., & Huang, B. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.08.033 · Cited by 175 · see citing works
Shi, Y., Lammers, T., Storm, G., & Hennink, W. E. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201600160 · Cited by 174 · see citing works
Self-citationClinical application of polymeric micelles for the treatment of cancer
Varela-Moreira, A., Shi, Y., Fens, M. H. A. M., Lammers, T., Hennink, W. E., & Schiffelers, R. M. (2017) · Materials Chemistry Frontiers · doi:10.1039/c6qm00289g · Cited by 168 · see citing works
Self-citationAsymmetric Flow Field-Flow Fractionation in the Field of Nanomedicine
Wagner, M., Holzschuh, S., Traeger, A., Fahr, A., & Schubert, U. S. (2014) · Analytical Chemistry · doi:10.1021/ac501664t · Cited by 141 · see citing works
Establishment of a New Extrahepatic Bile Duct Carcinoma Cell Line, TFK-1.
Saijyo, S., Kudo, T., Suzuki, M., et al. (1995) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.177.61 · Cited by 140 · see citing works
Mafra, L., Santos, S. M., Siegel, R., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja208647n · Cited by 140 · see citing works
Field flow fractionation techniques to explore the “nano-world”
Contado, C. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0180-6 · Cited by 133 · see citing works
Stability and release performance of a series of pegylated copolymeric micelles
Lin, W.-J., Juang, L.-W., & Lin, C.-C. (2003) · Pharmaceutical Research · doi:10.1023/a:1023215320026 · Cited by 125 · see citing works
A Kinetic Degradation Study of Curcumin in Its Free Form and Loaded in Polymeric Micelles
Naksuriya, O., van Steenbergen, M. J., Toraño, J. S., Okonogi, S., & Hennink, W. E. (2016) · The AAPS Journal · doi:10.1208/s12248-015-9863-0 · Cited by 120 · see citing works
Self-citationBarik, A., Mishra, B., Kunwar, A., et al. (2007) · Chemical Physics Letters · doi:10.1016/j.cplett.2007.01.006 · Cited by 112 · see citing works
Lübtow, M. M., Haider, M. S., Kirsch, M., Klisch, S., & Luxenhofer, R. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00618 · Cited by 111 · see citing works
Zhai, S., Ma, Y., Chen, Y., Li, D., Cao, J., Liu, Y., Cai, M., Xie, X., Chen, Y., & Luo, X. (2013) · Polymer Chemistry · doi:10.1039/c3py01325a · Cited by 107 · see citing works
Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle
Sun, M. H., Gao, Y., Guo, C., Cao, F., Song, Z., Xi, Y., Yu, A., Li, A., & Zhai, G. (2010) · Journal of Nanoparticle Research · doi:10.1007/s11051-010-9907-4 · Cited by 92 · see citing works
Overcoming the road blocks: advancement of block copolymer micelles for cancer therapy in the clinic
Houdaihed, L., Evans, J. C., & Allen, C. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00188 · Cited by 91 · see citing works
Lübtow, M. M., Nelke, L. C., Seifert, J., Kühnemundt, J., Sahay, G., Dandekar, G., Nietzer, S., & Luxenhofer, R. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.014 · Cited by 85 · see citing works
Bagheri, M., Bresseleers, J., Varela-Moreira, A., Sandre, O., Meeuwissen, S. A., Schiffelers, R. M., Metselaar, J. M., van Nostrum, C. F., van Hest, J. C. M., & Hennink, W. E. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b03576 · Cited by 82 · see citing works
Self-citationHPMA-based polymeric micelles for curcumin solubilization and inhibition of cancer cell growth
Naksuriya, O., Shi, Y., van Nostrum, C. F., Anuchapreeda, S., Hennink, W. E., & Okonogi, S. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.06.010 · Cited by 81 · see citing works
Self-citationCurcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions
Zhai, K., Brockmueller, A., Kubatka, P., Shakibaei, M., & Büsselberg, D. (2020) · Biomolecules · doi:10.3390/biom10111469 · Cited by 78 · see citing works
Sun, D., Zhou, J., Zhao, L., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b02863 · Cited by 70 · see citing works
Improving the anti-colon cancer activity of curcumin with biodegradable nano-micelles
Gao, X., Zheng, F., Guo, G. F., Liu, X., Fan, R., Qian, Z., Huang, N., & Wei, Y.-Q. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21091j · Cited by 59 · see citing works
Vader, P., van der Meel, R., Symons, M. H., Fens, M. H. A. M., Pieters, E. H. E., Wilschut, K. J., Storm, G., Jarzabek, M. A., Gallagher, W. M., Schiffelers, R. M., et al. (2011) · Angiogenesis · doi:10.1007/s10456-011-9229-x · Cited by 56 · see citing works
Self-citationTherapy‐induced antitumor vaccination in neuroblastomas by the combined targeting of IL‐2 and TNFα
Balza, E., Carnemolla, B., Mortara, L., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.25018 · Cited by 50 · see citing works
Curcumin-Loaded Blood-Stable Polymeric Micelles for Enhancing Therapeutic Effect on Erythroleukemia
Gong, F., Chen, D., Teng, X., Ge, J., Ning, X., Shen, Y., Li, J., & Wang, S. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b01171 · Cited by 47 · see citing works
Patil, S. S., Bhasarkar, S., & Rathod, V. K. (2019) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2019.1575859 · Cited by 45 · see citing works
Carignani, E., Borsacchi, S., Bradley, J. P., et al. (2013) · The Journal of Physical Chemistry C · doi:10.1021/jp4044946 · Cited by 42 · see citing works
Sidhar, H., & Giri, R. K. (2017) · Scientific Reports · doi:10.1038/srep41420 · Cited by 39 · see citing works
Hong, J., Liu, Y., Xiao, Y., Yang, X., Su, W., Zhang, M., Liao, Y., Kuang, H., & Wang, X. (2017) · Drug Delivery · doi:10.1080/10717544.2016.1233589 · Cited by 39 · see citing works
Chen, S., Li, Q., Li, H., Yang, L., Yi, J., Xie, M., & Zhang, L. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110636 · Cited by 39 · see citing works
Fens, M. H. A. M., Hill, K. J., Issa, J. J., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604675 · Cited by 32 · see citing works
Self-citationPreclinical Studies with Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes
Gabizón, A., Pappo, O., Goren, D., Chemla, M., Tzemach, D., & Horowitz, A. T. (1993) · Journal of Liposome Research · doi:10.3109/08982109309150734 · Cited by 32 · see citing works
Basu, A., & Kumar, G. S. (2013) · The Journal of Chemical Thermodynamics · doi:10.1016/j.jct.2013.10.037 · Cited by 31 · see citing works
Moquin, A., Sharma, A., Cui, Y., Lau, A., Maysinger, D., & Kakkar, A. K. (2015) · Macromolecular Bioscience · doi:10.1002/mabi.201500186 · Cited by 23 · see citing works
Varela-Moreira, A., van Straten, D., van Leur, H., Ruiter, R. W. J., Deshantri, A. K., Hennink, W. E., Fens, M. H. A. M., Groen, R. W. J., & Schiffelers, R. M. (2020) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2020.100049 · Cited by 21 · see citing works
Self-citationBresseleers, J., Bagheri, M., Storm, G., Metselaar, J. M., Hennink, W. E., Meeuwissen, S. A., & van Hest, J. C. M. (2019) · Organic Process Research & Development · doi:10.1021/acs.oprd.9b00387 · Cited by 20 · see citing works
Self-citationBolger, G. T., Licollari, A., Tan, A., et al. (2017) · Anticancer Research · doi:10.21873/anticanres.11716 · Cited by 18 · see citing works
Sheybanifard, M., Beztsinna, N., Bagheri, M., Buhl, E. M., Bresseleers, J., Varela-Moreira, A., Shi, Y., van Nostrum, C. F., van der Pluijm, G., Storm, G., et al. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119409 · Cited by 18 · see citing works
Self-citationAlbumin‐Assisted Method Allows Assessment of Release of Hydrophobic Drugs From Nanocarriers
Gil, D., Frank‐Kamenetskii, A., Barry, J., et al. (2017) · Biotechnology Journal · doi:10.1002/biot.201700337 · Cited by 9 · see citing works
Brown, D., & Tomlin, M. (2010) · Competency-based critical care · doi:10.1007/978-1-84996-146-2_2 · Cited by 9 · see citing works
Paul, A. (2019) · Introduction to Basics of Pharmacology and Toxicology · doi:10.1007/978-981-32-9779-1_6 · Cited by 6 · see citing works
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- Authors
- Bagheri, M., Fens, M. H., Kleijn, T. G., Capomaccio, R. B., Mehn, D., Krawczyk, P. M., Scutigliani, E. M., Gurinov, A., Baldus, M., van Kronenburg, N. C. H., Kok, R. J., Heger, M., van Nostrum, C. F., & Hennink, W. E.
- Affiliations
- Utrecht University (NL)
- European Commission (BE)
- Joint Research Centre (JRC) , , , ,
- Amsterdam University Medical Centers (NL)
- Utrecht University , , ,
- Corresponding author
- Hennink, Wim E.
- ORCID
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-01-19
- Volume
- 18
- Issue
- 3
- Pages
- 1247-1263
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- PMC
- PMC7927141
- OpenAlex
- W3123252613
- Cited by
- 61
- References
- 77
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 4 · 2012: 1
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Pharmaceutics (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, cc-by)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81872220)
- KWF Kankerbestrijding (10666)
- Natural Science Foundation of Zhejiang Province (Z20H160031)
- Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics (NA)
- Zhejiang Province (NA)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- curcumin, polymeric micelles, HPMA copolymer, nanoprecipitation, drug solubilization, pharmacokinetics, albumin binding, micelle stability, circulation time, tumor cell internalization
- MeSH terms
- Acrylamides, Animals, Antineoplastic Agents, Curcumin, Drug Carriers, Drug Compounding, Humans, Methacrylates, Micelles, Particle Size, Polyesters, Polyethylene Glycols, Polymers, Cell Line, Tumor, Mice, Hydrophobic and Hydrophilic Interactions, Human Umbilical Vein Endothelial Cells, Drug Liberation
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