Engineered Cellular Uptake and Controlled Drug Delivery Using Two Dimensional Nanoparticle and Polymer for Cancer Treatment
Abstract
Two major problems in chemotherapy, poor bioavailability of hydrophobic anticancer drug and its adverse side effects causing nausea, are taken into account by developing a sustained drug release vehicle along with enhanced bioavailability using two-dimensional layered double hydroxides (LDHs) with appropriate surface charge and its subsequent embedment in polymer matrix. A model hydrophobic anticancer drug, raloxifene hydrochloride (RH), is intercalated into a series of zinc iron LDHs with varying anion charge densities using an ion exchange technique. To achieve significant sustained delivery, drug-intercalated LDH is embedded in poly(ε-caprolactone) (PCL) matrix to develop intravenous administration and to improve the therapeutic index of the drug. The cause of sustained release is visualized from the strong interaction between LDH and drug, as measured through spectroscopic techniques, like X-ray photoelectron spectroscopy, infrared, UV-visible spectroscopy, and thermal measurement (depression of melting temperature and considerable reduction in heat of fusion), using differential scanning calorimeter, followed by delayed diffusion of drug from polymer matrix. Interestingly, polymer nanohybrid exhibits long-term and excellent in vitro antitumor efficacy as opposed to pure drug or drug-intercalated LDH or only drug embedded PCL (conventional drug delivery vehicle) as evident from cell viability and cell adhesion experiments prompting a model depicting greater killing efficiency (cellular uptake) of the delivery vehicle (polymer nanohybrid) controlled by its better cell adhesion as noticed through cellular uptake after tagging of fluorescence rhodamine B separately to drug and LDH. In vivo studies also confirm the sustained release of drug in the bloodstream of albino rats using polymer nanohybrid (novel drug delivery vehicle) along with a healthy liver vis-à-vis burst release using pure drug/drug-intercalated LDHs with considerable damaged liver.
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Drug release from layered double hydroxide formulations was controlled, and higher cytotoxicity was observed in HeLa cells, further confirmed through in vivo tumor suppression in a murine model, indicating its application as a drug delivery vehicle.
“The drug release was controlled, and higher cytotoxicity was observed in HeLa cells, which was further confirmed through in vivo tumor suppression in a murine model, indicating its application as a drug delivery vehicle.1,231”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [231]
Cites
1 retracted
Mahanta, A. K., Senapati, S., & Maiti, P. (2017) · Polymer Chemistry · doi:10.1039/c7py01218g · Cited by 52 · see citing works
Self-citationRetractedCancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
Understanding biophysicochemical interactions at the nano–bio interface
Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083 · see citing works
Analysis of XPS spectra of Fe2+ and Fe3+ ions in oxide materials
Yamashita, T., & Hayes, P. C. (2007) · Applied Surface Science · doi:10.1016/j.apsusc.2007.09.063 · Cited by 6,750 · see citing works
The return of a forgotten polymer—Polycaprolactone in the 21st century
Woodruff, M. A., & Hutmacher, D. W. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.002 · Cited by 4,033 · see citing works
Recent Advances in the Synthesis and Application of Layered Double Hydroxide (LDH) Nanosheets
Wang, Q., & O'Hare, D. M. (2012) · Chemical Reviews · doi:10.1021/cr200434v · Cited by 3,515 · see citing works
Bray, F., Jemal, A., Grey, N., Ferlay, J., & Forman, D. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70211-5 · Cited by 2,225 · see citing works
Polymer surface modification for the attachment of bioactive compounds
Goddard, J. M., & Hotchkiss, J. H. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.04.002 · Cited by 1,383 · see citing works
Synthesis and barrier properties of poly(ε‐caprolactone)‐layered silicate nanocomposites
Messersmith, P. B., & Giannelis, E. P. (1995) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.1995.080330707 · Cited by 1,218 · see citing works
Intercalation chemistry of layered double hydroxides: recent developments and applications
Khan, A. I., & O'Hare, D. M. (2002) · Journal of Materials Chemistry · doi:10.1039/b204076j · Cited by 1,190 · see citing works
Physical Principles of Nanoparticle Cellular Endocytosis
Zhang, S., Gao, H., & Bao, G. (2015) · ACS Nano · doi:10.1021/acsnano.5b03184 · Cited by 1,148 · see citing works
Inorganic nanoparticles as carriers for efficient cellular delivery
Xu, Z. P., Zeng, Q., Lu, G. Q., & Yu, A. (2005) · Chemical Engineering Science · doi:10.1016/j.ces.2005.06.019 · Cited by 976 · see citing works
Duan, X., & Evans, D. G. (2005) · Structure and bonding · doi:10.1007/b100426 · Cited by 966 · see citing works
Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency
Lesniak, A., Salvati, A. L., Santos-Martínez, M. J., Radomski, M. W., Dawson, K. A., & Åberg, C. (2013) · Journal of the American Chemical Society · doi:10.1021/ja309812z · Cited by 853 · see citing works
Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery
Sinha, R., Gloria, K., Nie, S., & Shin, D. M. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0141 · Cited by 802 · see citing works
Nanooncology: The future of cancer diagnosis and therapy
Thakor, A. S., & Gambhir, S. S. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21199 · Cited by 591 · see citing works
Nanomaterials for Drug Delivery
Hubbell, J. A., & Chilkoti, A. (2012) · Science · doi:10.1126/science.1219657 · Cited by 532 · see citing works
Parida, K. M., & Mohapatra, L. (2011) · Chemical Engineering Journal · doi:10.1016/j.cej.2011.10.070 · Cited by 364 · see citing works
Feng, S., Mei, L., Anitha, P., et al. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.045 · Cited by 306 · see citing works
Self-Assembly and Characterization of Layered Double Hydroxide/DNA Hybrids
Desigaux, L., Belkacen, M. B., Richard, P., et al. (2005) · Nano Letters · doi:10.1021/nl052020a · Cited by 282 · see citing works
Subcellular compartment targeting of layered double hydroxide nanoparticles
Xu, Z. P., Niebert, M., Porazik, K., Walker, T. L., Cooper, H. M., Middelberg, A. P. J., Gray, P. P., Bartlett, P. F., & Lu, G. Q. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.021 · Cited by 279 · see citing works
Nanometer surface roughness increases select osteoblast adhesion on carbon nanofiber compacts
Price, R. L., Ellison, K. S., Haberstroh, K. M., & Webster, T. J. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30073 · Cited by 266 · see citing works
Nakayama, H., Wada, N., & Tsuhako, M. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.09.043 · Cited by 262 · see citing works
神山, 雅., Gao, C., & 小角, 卓. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00247-8 · Cited by 225 · see citing works
Schleich, N., Sibret, P., Danhier, P., Učakar, B., Laurent, S., Müller, R. N., Jérôme, C., Gallez, B., Véronique Préat, A., & Danhier, F. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.042 · Cited by 215 · see citing works
Oh, J., Choi, S., Lee, G., et al. (2008) · Chemistry - An Asian Journal · doi:10.1002/asia.200800290 · Cited by 197 · see citing works
Choi, S., & Choy, J. (2011) · Nanomedicine · doi:10.2217/nnm.11.86 · Cited by 194 · see citing works
Senapati, S., Thakur, R., Verma, S. P., Duggal, S., Mishra, D. P., Das, P., Shripathi, T., Kumar, M., Rana, D., & Maiti, P. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.016 · Cited by 155 · see citing works
Self-citationYou, Y., Zhao, H., & Vance, G. F. (2002) · Applied Clay Science · doi:10.1016/s0169-1317(01)00102-8 · Cited by 137 · see citing works
New Developments in the Origins of the Homochirality of Biologically Relevant Molecules
Buschmann, H., Thede, R., & Heller, D. (2000) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20001117)39:22 · Cited by 111 · see citing works
Polyurethane-Grafted Chitosan as New Biomaterials for Controlled Drug Delivery
Mahanta, A. K., Mittal, V., Singh, N., Dash, D., Malik, S., Kumar, M., & Maiti, P. (2015) · Macromolecules · doi:10.1021/acs.macromol.5b00030 · Cited by 110 · see citing works
Self-citationKim, I. Y., Kim, B.-C., Seong, D. H., et al. (2002) · PubMed · Cited by 108 · see citing works
Dramatic activities of vanadate intercalated bismuth doped LDH for solar light photocatalysis
Mohapatra, L., & Parida, K. M. (2014) · Physical Chemistry Chemical Physics · doi:10.1039/c4cp01665c · Cited by 101 · see citing works
Gasser, M. S. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.05.005 · Cited by 100 · see citing works
Cellular uptake and gene delivery using layered double hydroxide nanoparticles
Li, S., Li, J., Wang, C. J., et al. (2012) · Journal of Materials Chemistry B · doi:10.1039/c2tb00081d · Cited by 94 · see citing works
Choi, S., Oh, J., & Choy, J. (2010) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2010.1415 · Cited by 87 · see citing works
Byczkowska, A., Kunikowska, A., & Kaźmierczak, A. (2012) · PROTOPLASMA · doi:10.1007/s00709-012-0383-9 · Cited by 76 · see citing works
Controlled drug release through regulated biodegradation of poly(lactic acid) using inorganic salts
Kumar, S., Singh, S., Senapati, S., Singh, A. P., Ray, B., & Maiti, P. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.06.033 · Cited by 75 · see citing works
Self-citationGago, S., Costa, T., de Melo, J. S. S., Gonçalves, I. S., & Pillinger, M. (2008) · Journal of Materials Chemistry · doi:10.1039/b715319h · Cited by 71 · see citing works
Gold nanoparticle-protein agglomerates as versatile nanocarriers for drug delivery.
Khandelia, R., Jaiswal, A. K., Ghosh, S., & Chattopadhyay, A. (2013) · Small · doi:10.1002/smll.201203095 · Cited by 69 · see citing works
Rai, A., Senapati, S., Saraf, S. K., & Maiti, P. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01623e · Cited by 69 · see citing works
Self-citationFunctionalized Graphene Tagged Polyurethanes for Corrosion Inhibitor and Sustained Drug Delivery
Patel, D. K., Senapati, S., Mourya, P., Singh, M. M., Aswal, V. K., Ray, B., & Maiti, P. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00342 · Cited by 69 · see citing works
Self-citationWang, G., Xu, S., Xia, C., Yan, D., Lin, Y., & Wei, M. (2015) · RSC Advances · doi:10.1039/c5ra00589b · Cited by 56 · see citing works
TiO2/ZnLDH as a Self-Assembled Nanocomposite with Photoresponsive Properties
Cârjă, G., Nakajima, A., Dranca, S., et al. (2010) · The Journal of Physical Chemistry C · doi:10.1021/jp103210m · Cited by 55 · see citing works
Djebbi, M. A., Elabed, A., Bouaziz, Z., Sadiki, M., Elabed, S., Namour, P., Jaffrezic-Renault, N. J., & Amara, A. B. H. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.09.089 · Cited by 52 · see citing works
Tian, Y., Guo, R., Wang, Y., & Yang, W. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600877 · Cited by 42 · see citing works
Influence of graphene on self-assembly of polyurethane and evaluation of its biomedical properties
Patel, D. K., Rana, D., Aswal, V. K., Srivastava, S., Roy, P., & Maiti, P. (2015) · Polymer · doi:10.1016/j.polymer.2015.03.076 · Cited by 41 · see citing works
Self-citationYang, Z. Y., Zhang, Z. F., He, X., et al. (2006) · Chromatographia · doi:10.1365/s10337-006-0123-4 · Cited by 35 · see citing works
Novel shape memory behaviour in IPDI based polyurethanes: Influence of nanoparticle
Srivastava, S., Biswas, A., Senapati, S., Ray, B., Rana, D. K., Aswal, V. K., & Maiti, P. (2016) · Polymer · doi:10.1016/j.polymer.2016.12.080 · Cited by 33 · see citing works
Self-citationMUC1-Targeted Cancer Cell Photothermal Ablation Using Bioinspired Gold Nanorods
Zelasko-Leon, D. C., Fuentes, C., & Messersmith, P. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128756 · Cited by 31 · see citing works
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Self-citationMahanta, A. K., Senapati, S., Paliwal, P., Krishnamurthy, S., Hemalatha, S., & Maiti, P. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00995 · Cited by 81 · see citing works
Self-citationControlling Drug Delivery Using Nanosheet-Embedded Electrospun Fibers for Efficient Tumor Treatment
Kumar, S., Singh, A. P., Senapati, S., & Maiti, P. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00735 · Cited by 36 · see citing works
Self-citationShukla, A., Singh, A. P., Dubey, T., Hemalatha, S., & Maiti, P. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00171 · Cited by 27 · see citing works
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- Authors
- Senapati, S., Shukla, R., Tripathi, Y. B., Mahanta, A. K., Rana, D., & Maiti, P.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Institute of Medical Sciences (IN)
- University of Ottawa (CA)
- Corresponding author
- Maiti, Pralay
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-01-18
- Volume
- 15
- Issue
- 2
- Pages
- 679-694
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2782133571
- Cited by
- 62
- References
- 50
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 12 · 2018: 5
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Science and Engineering Research Board (EMR/2015/001409)
- Indian Institute of Technology, Banaras Hindu University (IIT(BHU)/R&D/IRP/2015-16/2817)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Layered Double Hydroxides Synthesis and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Keywords
- layered double hydroxides, raloxifene hydrochloride, polycaprolactone, sustained drug release, controlled drug delivery, hydrophobic anticancer drugs, drug intercalation, ion exchange, polymer nanohybrids, cellular uptake, cell adhesion, intravenous administration, antitumor efficacy, hepatotoxicity, burst release, two-dimensional nanoparticles
- MeSH terms
- Animals, Antineoplastic Agents, Biological Availability, Chemical Engineering, Delayed-Action Preparations, Diffusion, Female, HeLa Cells, Humans, Hydroxides, Liver, Neoplasms, Polymers, Pharmaceutical Vehicles, X-Ray Diffraction, 3T3 Cells, Drug Delivery Systems, Zinc Compounds, Inhibitory Concentration 50, Raloxifene Hydrochloride, Mice, Rats, Nanoparticles, Hydrophobic and Hydrophilic Interactions
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