Nanostructure controlled anti-cancer drug delivery using poly(ε-caprolactone) based nanohybrids
Abstract
We have focused on the generation of various nanostructures of poly(ε-caprolactone) (PCL) using surface modified layered silicate. The improved and diverse mechanical, thermal and surface properties have been explored depending upon the nanostructure of the nanohybrids. The incorporation of drug into those nanohybrids further alters the nanostructure and subsequent properties. The rate of biodegradation has been studied in detail, with plausible mechanisms in different enzyme media being suggested, their specificity and the tunability of the biodegradation rate was demonstrated, followed by their optimization. The scaffolds of PCL and its nanohybrids with and without drugs have been prepared through electrospinning to control the dimensions of the nanofibers and their controlled degradation. The in-depth studies of the biocompatibility in terms of cell adhesion, genotoxicity and hemocompatibility have been performed to verify the suitability of the nanohybrids for potential biomedical applications. The biocompatibility of the nanohybrids at the gene level has been tested by the subcellular localization of an important regulator of pro-apoptotic signalling cascade, HIPK2 in human epithelial cells, demonstrating the attuned nature of the particles under study within the biological system. The blood compatibilities of the pure PCL and its nanohybrids were studied by platelet aggregation, platelet adhesion, and in vitro hemolysis assay, elucidating the excellent hemocompatibility of the novel nanohybrids. Biocompatible and hemocompatible nanohybrids have been testified for drug delivery and show sustained and controlled release of anti-cancer drugs (dexamethasone) in the presence of two dimensional disc-like nanoparticles. Hence, the developed nanohybrids are a potential biomaterial, suitable for tissue engineering and drug delivery.
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Several classes of materials have been developed for targeted therapy, including biodegradable polymers, liposomes, dendrimers, nanoshells and nucleic acid-based nanoparticles.
“Several classes of materials have been developed to date for targeted therapy, including biodegradable polymers, liposomes, dendrimers, nanoshells and nucleic acid-based NPs.2”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [2]
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- Authors
- Singh, N. K., Singh, S. K., Dash, D., Das Purkayastha, B. P., Roy, J. K., & Maiti, P.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Institute of Medical Sciences (IN)
- Banaras Hindu University (IN)
- Corresponding author
- Maiti, Pralay
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 22
- Issue
- 34
- Pages
- 17853
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W2033802572
- Cited by
- 49
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Keywords
- polycaprolactone, layered silicate nanocomposites, drug delivery, anticancer agents, dexamethasone, electrospun nanofibers, controlled biodegradation, hemocompatibility, biocompatibility, genotoxicity, platelet adhesion, hemolysis, tissue engineering scaffolds, sustained drug release
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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