In Situ Formation of Nanotheranostics to Overcome the Blood–Brain Barrier and Enhance Treatment of Orthotopic Glioma
Abstract
Glioblastoma is one of the most lethal cancers and needs effective therapeutics. The development of coordination-driven metal–organic nanoassemblies, which can cross the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB) and have multiple desired functions, may provide a promising solution to this issue. Here, we report an in situ assembled nanoplatform based on RGD peptide-modified bisulfite-zinc II -dipicolylamine-Arg-Gly-Asp (Bis(DPA-Zn)-RGD) and ultrasmall Au-ICG nanoparticles. Attributed to its positive charges and neovascular targeting properties, Bis(DPA-Zn)-RGD can be selectively delivered to the tumor site, and then assembled in situ into large nanoclusters with subsequently administered Au-ICG nanoparticles. Au nanoparticles with ultrasmall size (∼7 nm) can successfully cross the BBB. The obtained nanoclusters exhibit strong near-infrared-red (NIR) absorption and an enhanced tumor retention effect, enabling precise orthotopic fluorescence/photoacoustic imaging. With the aid of image guidance, the photothermal effect of the nanoclusters is observed to suppress tumor progression with the inhibition efficiency reaching up to 93.9%. Meanwhile, no photothermal damage can be found for normal brain tissues. These results, herein, suggest a feasible nanotheranostic agent with the ability to overcome the BBB and BBTB for imaging and therapy of orthotopic brain tumors.
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Gao et al. used RGD polypeptide to modify Bis(DPA-Zn)-RGD, which can be selectively delivered to tumor sites due to RGD's new blood vessel targeting properties.
“Gao et al. used RGD polypeptide to modify bisulfite-zincII-dipicolylamine (Bis(DPA-Zn)-RGD). Due to the new blood vessel targeting properties of RGD, Bis(DPA-Zn)-RGD can be selectively delivered to tumor sites.”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [218]
The R/Au-ICG nanoclusters can penetrate the blood-brain barrier and inhibit the growth of brain tumors in mice.
“The newly developed gold nanoclusters can penetrate the blood-brain barrier and use its high photothermal effect to inhibit the growth of brain tumors in mice.218”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [218]
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- Authors
- Gao, H., Chu, C., Cheng, Y., Zhang, Y., Pang, X., Li, D., Wang, X., Ren, E., Xie, F., Bai, Y., Chen, L., Liu, G., & Wang, M.
- Affiliations
- Zhengzhou University (CN)
- Xiamen University (CN)
- Corresponding author
- Liu, Gang
- Wang, Meiyun
- ORCID
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-05-22
- Volume
- 12
- Issue
- 24
- Pages
- 26880-26892
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W3026950172
- Cited by
- 59
- References
- 68
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 17 · 2021: 10
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education of the People's Republic of China (20720190088)
- Ministry of Science and Technology of the People's Republic of China (2017YFA0205201, 2017YFE0103600, 2018YFA0107301)
- National Natural Science Foundation of China (31470047, 81422023, 81603015, 81641168, 81720108021, 81772009, 81871404, U1505221, U1705281)
- Henan Province (182102310162)
- Zhongyuan Thousand Talents Plan Project - Basic Research Leader Talent (ZYQR201810117)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- glioblastoma, blood-brain barrier, blood-brain tumor barrier, nanotheranostics, zinc coordination, RGD peptide, dipicolylamine, gold nanoparticles, indocyanine green, photothermal therapy, near-infrared fluorescence imaging, photoacoustic imaging, tumor targeting
- MeSH terms
- Theranostic Nanomedicine, Animals, Blood-Brain Barrier, Glioma, Gold, Humans, Metal Nanoparticles, Tumor Microenvironment
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