The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Drug delivery systems and materials for wound healing applications
Open accessAbstract
Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted.
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Cited by
Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques
Vigata, M., Meinert, C., Hutmacher, D. W., & Bock, N. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121188 · Cited by 544
The production and application of hydrogels for wound management: A review
Gupta, A., Kowalczuk, M., Heaselgrave, W., Britland, S. T., Martin, C., & Radecka, I. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2018.12.019 · Cited by 336
Xu, G., Lu, Y., Cheng, C., Li, X., Xu, J., Liu, Z., Liu, J., Liu, G., Shi, Z., Chen, Z., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100852 · Cited by 336
On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook
Montoya, C., Du, Y., Gianforcaro, A. L., Orrego, S., Yang, M., & Lelkes, P. I. (2021) · Bone Research · doi:10.1038/s41413-020-00131-z · Cited by 298
Chen, M., Tian, J., Liu, Y., Cao, H., Li, R., Wang, J., Wu, J., & Zhang, Q. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.05.043 · Cited by 281
Metadata
- Authors
- Saghazadeh, S., Rinoldi, C., Schot, M., Kashaf, S. S., Sharifi, F., Jalilian, E., Nuutila, K., Giatsidis, G., Mostafalu, P., Derakhshandeh, H., Yue, K., Swieszkowski, W., Memic, A., Tamayol, A., & Khademhosseini, A.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 127
- Pages
- 138-166
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2795652485
- Cited by
- 842
- References
- 22
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Saghazadeh, S., Rinoldi, C., Schot, M., Kashaf, S. S., Sharifi, F., Jalilian, E., Nuutila, K., Giatsidis, G., Mostafalu, P., Derakhshandeh, H., Yue, K., Swieszkowski, W., Memic, A., Tamayol, A., & Khademhosseini, A. (2018). Drug delivery systems and materials for wound healing applications. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2018.04.008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
