The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Dendritic Hydrogels with Robust Inherent Antibacterial Properties for Promoting Bacteria-Infected Wound Healing
Abstract
Bacterial infections are a common problem associated with wound treatment that imposes a significant burden on healthcare systems and patients. As a result, healthcare providers urgently need new treatment strategies to protect people. Hydrogel biomaterials with inherent antimicrobial properties offer an attractive and viable solution to this issue. Here, for the first time, we have developed a new efficient synthetic strategy to prepare cationic hydrogels (PHCI) with intrinsically efficient antimicrobial properties by chemically cross-linking trans -1,4-cyclohexanediamine with 1,3-dibromo-2-propanol using a condensation reaction without the use of toxic cross-linking agents. As expected, the prepared PHCI hydrogel possessed an inherent antibacterial ability that can adsorb and kill Staphylococcus aureus and Escherichia coli electrostatically. Notably, in vivo experiments on normal and diabetic rat models confirmed that the PHCI hydrogel can quickly stop bleeding, efficiently kill bacteria, promote the conversion of macrophages from the proinflammatory M1 phenotype to the repaired M2 phenotype, and accelerate collagen deposition and blood vessel formation, thereby achieving rapid wound healing. Overall, this work presents an effective antibacterial dressing that might provide a facile but effective approach for clinical wound management.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research
Turner, N. A., Sharma-Kuinkel, B. K., Maskarinec, S. A., Eichenberger, E. M., Shah, P. P., Carugati, M., Holland, T. L., & Fowler, V. G. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0147-4 · Cited by 2,051
Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,083
Drug delivery systems and materials for wound healing applications
Saghazadeh, S., Rinoldi, C., Schot, M., Kashaf, S. S., Sharifi, F., Jalilian, E., Nuutila, K., Giatsidis, G., Mostafalu, P., Derakhshandeh, H., et al. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.008 · Cited by 842
Antibacterial Carbon‐Based Nanomaterials
Xin, Q., Shah, H., Nawaz, A., Xie, W., Akram, M. Z., Batool, A., Tian, L., Jan, S. U., Boddula, R., Guo, B., et al. (2019) · Advanced Materials · doi:10.1002/adma.201804838 · Cited by 814
Fan, Z., Liu, B., Wang, J., Zhang, S., Lin, Q., Gong, P., Ma, L., & Yang, S. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201304202 · Cited by 812
Wound healing and treating wounds
Powers, J. G., Higham, C., Broussard, K., & Phillips, T. J. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.08.070 · Cited by 753
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A. R., Buse, J. B., Langer, R., & Gu, Z. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0508-y · Cited by 604
Zhu, Y., Zhang, J., Song, J., Yang, J., Du, Z., Zhao, W., Guo, H., Wen, C., Li, Q., Sui, X., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201905493 · Cited by 538
Gao, G., Jiang, Y.-W., Jia, H.-R., & Wu, F.-G. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.045 · Cited by 485
Li, M., Liang, Y., He, J., Zhang, H., & Guo, B. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.0c02823 · Cited by 479
SMITH, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.04.007 · Cited by 443
A Cooperative Copper Metal–Organic Framework‐Hydrogel System Improves Wound Healing in Diabetes
Xiao, J., Chen, S., Yi, J., Zhang, H. F., & Ameer, G. A. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201604872 · Cited by 428
Chronic wounds: Current status, available strategies and emerging therapeutic solutions
Las Heras, K., Igartua, M., Santos-Vizcaino, E., & Hernandez, R. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.039 · Cited by 370
Ge, C., Wu, R., Chong, Y., Fang, G., Jiang, X., Pan, Y., Chen, C., & Yin, J. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201801484 · Cited by 300
Zheng, K., Tong, Y., Zhang, S., He, R., Xiao, L., Iqbal, Z., Zhang, Y., Gao, J., Zhang, L., Jiang, L., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202102599 · Cited by 290
Zeng, Q., Qian, Y., Huang, Y., Ding, F., Qi, X., & Shen, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.035 · Cited by 246
Self-citationTang, P., Han, L., Li, P., Jia, Z., Wang, K., Zhang, H., Tan, H., Guo, T., & Lu, X. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b18931 · Cited by 243
Yan, X., Fang, W.-W., Xue, J., Sun, T.-C., Dong, L., Zha, Z., Qian, H., Song, Y.-H., Zhang, M., Gong, X., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b02845 · Cited by 228
A Nanocomposite Hydrogel with Potent and Broad-Spectrum Antibacterial Activity
Dai, T., Wang, C., Wang, Y., Xu, W., Hu, J., & Cheng, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b02527 · Cited by 218
Townsend, J. M., Beck, E. C., Gehrke, S. H., Berkland, C. J., & Detamore, M. S. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.01.003 · Cited by 215
Cao, C., Yang, N., Zhao, Y., Yang, D., Hu, Y., Yang, D., Song, X., Wang, W., & Dong, X. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101165 · Cited by 205
Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern
Liu, R., Chen, X., Chakraborty, S., Lemke, J. J., Hayouka, Z., Chow, C., Welch, R. A., Weisblum, B., Masters, K. S., & Gellman, S. H. (2014) · Journal of the American Chemical Society · doi:10.1021/ja500367u · Cited by 193
Synthesis of Cu-Nanoparticle Hydrogel with Self-Healing and Photothermal Properties
Chen, S., Tang, F., Tang, L., & Li, L. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b04956 · Cited by 187
Hydrogels in Emerging Technologies for Type 1 Diabetes
Fuchs, S., Ernst, A. U., Wang, L., Shariati, K., Wang, X., Liu, Q., & Ma, M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01062 · Cited by 163
Choi, S. K., Myc, A., Silpe, J. E., Sumit, M., Wong, P. T., McCarthy, K. A., Desai, A. M., Thomas, T. P., Kotlyar, A., Holl, M. M. B., et al. (2012) · ACS Nano · doi:10.1021/nn3038995 · Cited by 148
Pan, J., Jin, Y. P., Lai, S., Shi, L., Fan, W., & Shen, Y. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.04.001 · Cited by 145
Ling, Z., Chen, Z., Deng, J. G., Wang, Y., Yuan, B., Yang, X., Lin, H., Cao, J., Zhu, X., & Zhang, X. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130302 · Cited by 141
Self-citationAntibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants
Xu, Z., Li, M., Li, X., Liu, X., Ma, F., Wu, S., Yeung, K., Han, Y. N., & Chu, P. K.-H. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04161 · Cited by 116
Qi, X., Su, T., Zhang, M., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b20794 · Cited by 105
Self-citationEfficient Decontamination of Lead Ions from Wastewater by Salecan Polysaccharide-Based Hydrogels
Qi, X., Lin, L., Shen, L., Li, Z., Qin, T., Qian, Y., Wu, X., Wei, X., Gong, Q., & Shen, J. (2019) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.9b02139 · Cited by 97
Self-citationKhan, M. I., Paul, P., Behera, S. K., Jena, B., Tripathy, S. K., Lundborg, C. S., & Mishra, A. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.128025 · Cited by 80
Wang, R., Xu, D., Liang, L., Xu, T., Liu, W., Ouyang, P., Chi, B., & Xu, H. L. (2016) · RSC Advances · doi:10.1039/c5ra15616e · Cited by 71
Zhou, C. Z., Sheng, C., Gao, L., Guo, J., Li, P., & Liu, B. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127429 · Cited by 67
Fox, S. J., Fazil, M. H. U. T., Dhand, C., Mayandi, V., Goh, E. T. L., Harini, S., Eugene, C., Lim, R. R., Ramakrishna, S., Chaurasia, S. S., et al. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.04.015 · Cited by 52
Wang, Z., Liu, L., Bu, W., Zheng, M., Jin, N., Zhang, K., Xu, X., Zhou, D., Yang, B. J., & Sun, H. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202004886 · Cited by 40
Self-citationTime Heals All Wounds … But Wounds Heal Faster with Lactobacillus
Davis, F. M., & Gallagher, K. A. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.03.018 · Cited by 32
Lin, Y., Xiong, K., Lü, Z., Liu, S., Zhang, Z., Lu, Y., Fu, R., & Wu, D. (2017) · Chemical Communications · doi:10.1039/c7cc04621a · Cited by 18
Cited by
Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems
Delgado-Pujol, E. J., Martínez, G., Casado-Jurado, D., Vázquez, J., León-Barberena, J., Rodríguez-Lucena, D., Torres, Y., Alcudia, A., & Begines, B. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020215 · Cited by 216
Chen, Y., Zhang, Y., Chang, L., Sun, W., Duan, W., & Qin, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125644 · Cited by 35
Metadata
- Authors
- Cheng, S., Wang, H., Pan, X., Zhang, C., Zhang, K., Chen, Z., Dong, W., Xie, A., & Qi, X.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-02-23
- Volume
- 14
- Issue
- 9
- Pages
- 11144-11155
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W4212817653
- Cited by
- 386
- References
- 39
- FWCI
- 25.82
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
