The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Carbon Dot-Based Platform for Simultaneous Bacterial Distinguishment and Antibacterial Applications
Abstract
In this work, we prepared quaternized carbon dots (CDs) with simultaneous antibacterial and bacterial differentiation capabilities using a simple carboxyl-amine reaction between lauryl betaine and amine-functionalized CDs. The obtained quaternized CDs have several fascinating properties/abilities: (1) A long fluorescence emission wavelength ensures the exceptional bacterial imaging capability, including the super-resolution imaging ability; (2) the polarity-sensitive fluorescence emission property leads to significantly enhanced fluorescence when the quaternized CDs interact with bacteria; (3) the presence of both hydrophobic hydrocarbon chains and positively charged quaternary ammonium groups makes the CDs selectively attach to Gram-positive bacteria, realizing the bacterial differentiation; (4) excellent antimicrobial activity is seen against Gram-positive bacteria with a minimum inhibitory concentration of 8 μg/mL for Staphylococcus aureus. Besides, the quaternized CDs are highly stable in various aqueous solutions and exhibit negligible cytotoxicity, suggesting that they hold great promise for clinical applications. Compared to the traditional Gram staining method, the selective Gram-positive bacterial imaging achieved by the quaternized CDs provides a much simpler and faster method for bacterial differentiation. In summary, by combining selective Gram-positive bacterial recognition, super-resolution imaging, and exceptional antibacterial activity into a single system, the quaternized CDs represent a novel kind of metal-free nanoparticle-based antibiotics for antibacterial application and a new type of reagent for efficient bacterial differentiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Quantum-Sized Carbon Dots for Bright and Colorful Photoluminescence
Sun, Y.-P., Zhou, B., Lin, Y., Wang, W., Fernando, K. A. S., Pathak, P., Meziani, M. J., Harruff, B. A., Wang, X., Wang, H., et al. (2006) · Journal of the American Chemical Society · doi:10.1021/ja062677d · Cited by 5,114
Metal-free efficient photocatalyst for stable visible water splitting via a two-electron pathway
Liu, J., Liu, Y., Liu, N., Han, Y., Zhang, X., Huang, H., Lifshitz, Y., Lee, S.-T., Zhong, J., & Kang, Z. (2015) · Science · doi:10.1126/science.aaa3145 · Cited by 4,468
Self-citationAntibacterial resistance worldwide: causes, challenges and responses
Levy, S. B., & Marshall, B. (2004) · Nature Medicine · doi:10.1038/nm1145 · Cited by 4,052
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging
Zhu, S., Meng, Q., Wang, L., Zhang, J., Song, Y., Jin, H., Zhang, K., Sun, H., Wang, H., & Yang, B. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201300519 · Cited by 3,720
Nugent, R. P., Krohn, M. A., & Hillier, S. L. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.2.297-301.1991 · Cited by 3,331
Full-Color Light-Emitting Carbon Dots with a Surface-State-Controlled Luminescence Mechanism
Ding, H., Yu, S.-B., Wei, J.-S., & Xiong, H.-M. (2016) · ACS Nano · doi:10.1021/acsnano.5b05406 · Cited by 2,530
A new medium for the enumeration and subculture of bacteria from potable water
Reasoner, D. J., & Geldreich, E. E. (1985) · Applied and Environmental Microbiology · doi:10.1128/aem.49.1.1-7.1985 · Cited by 2,300
Antibiotics for Emerging Pathogens
Fischbach, M. A., & Walsh, C. T. (2009) · Science · doi:10.1126/science.1176667 · Cited by 1,777
Li, Y., Hu, Y., Zhao, Y., Shi, G., Deng, L., Hou, Y., & Qu, L. (2011) · Advanced Materials · doi:10.1002/adma.201003819 · Cited by 1,618
Self-citationPerformance comparison of benchtop high-throughput sequencing platforms
Loman, N. J., Misra, R. V., Dallman, T. J., Constantinidou, C., Gharbia, S. E., Wain, J., & Pallen, M. J. (2012) · Nature Biotechnology · doi:10.1038/nbt.2198 · Cited by 1,337
Nie, H., Li, M., Li, Q., Liang, S., Tan, Y., Sheng, L., Shi, W., & Zhang, S. X.-A. (2014) · Chemistry of Materials · doi:10.1021/cm5003669 · Cited by 955
A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability
Li, P., Poon, Y. F., Li, W., Zhu, H.-Y., Yeap, S. H., Cao, Y., Qi, X., Zhou, C., Lamrani, M., Beuerman, R. W., et al. (2011) · Nature Materials · doi:10.1038/nmat2915 · Cited by 822
Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria
Li, X., Robinson, S. M., Gupta, A., Saha, K., Jiang, Z., Moyano, D. F., Sahar, A., Riley, M. A., & Rotello, V. M. (2014) · ACS Nano · doi:10.1021/nn5042625 · Cited by 765
Liu, C., Zhang, P., Zhai, X., Tian, F., Li, W., Yang, J., Liu, Y., Wang, H., Wang, W., & Liu, W. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.052 · Cited by 756
Self-citationPresenting Vancomycin on Nanoparticles to Enhance Antimicrobial Activities
Gu, H., Ho, P. L., Tong, E., Wang, L., & Xu, B. (2003) · Nano Letters · doi:10.1021/nl034396z · Cited by 703
Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells.
Zheng, M., Ruan, S., Liu, S., Sun, T., Qu, D., Zhao, H., Xie, Z., Gao, H., Jing, X., & Sun, Z. (2015) · ACS Nano · doi:10.1021/acsnano.5b05575 · Cited by 593
Color-Switchable Electroluminescence of Carbon Dot Light-Emitting Diodes
Zhang, X., Zhang, Y., Wang, Y., Kalytchuk, S., Kershaw, S. V., Wang, Y., Wang, P., Zhang, T., Zhao, Y., Zhang, H., et al. (2013) · ACS Nano · doi:10.1021/nn405017q · Cited by 534
Self-citationTang, J., Chen, Q., Xu, L., Zhang, S., Feng, L., Cheng, L., Xu, H., Liu, Z., & Peng, R. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am4005495 · Cited by 484
Bao, Q., Zhang, D., & Qi, P. (2011) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2011.05.009 · Cited by 465
High-throughput bacterial genome sequencing: an embarrassment of choice, a world of opportunity
Loman, N. J., Constantinidou, C., Chan, J. Z. M., Halachev, M., Sergeant, M., Penn, C. W., Robinson, E. R., & Pallen, M. J. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2850 · Cited by 427
Bioimaging based on fluorescent carbon dots
Song, Y., Zhu, S., & Yang, B. (2014) · RSC Advances · doi:10.1039/c3ra47994c · Cited by 414
Detection and Identification of Microorganisms by Gene Amplification and Sequencing
Reller, L. B., Weinstein, M. P., & Petti, C. A. (2007) · Clinical Infectious Diseases · doi:10.1086/512818 · Cited by 351
Nanoparticle approaches against bacterial infections
Gao, W., Thamphiwatana, S., Angsantikul, P., & Zhang, L. (2014) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1282 · Cited by 347
High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes
Edgar, R., McKinstry, M., Hwang, J., Oppenheim, A. B., Fekete, R. A., Giulian, G., Merril, C., Nagashima, K., & Adhya, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601211103 · Cited by 338
Gong, X., Zhang, Q., Gao, Y., Shuang, S., Choi, M. M. F., & Dong, C. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01577 · Cited by 311
Core–Shell Supramolecular Gelatin Nanoparticles for Adaptive and “On-Demand” Antibiotic Delivery
Li, L.-L., Xu, J.-H., Qi, G.-B., Zhao, X., Yu, F., & Wang, H. (2014) · ACS Nano · doi:10.1021/nn501040h · Cited by 291
Zhu, C., Yang, Q., Liu, L., Lv, F., Li, S., Yang, G., & Wang, S. (2011) · Advanced Materials · doi:10.1002/adma.201102850 · Cited by 277
Aggregation and Interaction of Cationic Nanoparticles on Bacterial Surfaces
Hayden, S. C., Zhao, G., Saha, K., Phillips, R. L., Li, X., Miranda, O. R., Rotello, V. M., El-Sayed, M. A., Schmidt-Krey, I., & Bunz, U. H. F. (2012) · Journal of the American Chemical Society · doi:10.1021/ja301167y · Cited by 267
Visible-Light-Activated Bactericidal Functions of Carbon “Quantum” Dots
Meziani, M. J., Dong, X., Zhu, L., Jones, L. P., LeCroy, G. E., Yang, F., Wang, S., Wang, P., Zhao, Y., Yang, L., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01765 · Cited by 263
Mothershed, E. A., & Whitney, A. M. (2006) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.05.050 · Cited by 261
Antibacterial discovery and development—the failure of success?
Fernandes, P. (2006) · Nature Biotechnology · doi:10.1038/nbt1206-1497 · Cited by 246
Graphene-Based Nanocomposite As an Effective, Multifunctional, and Recyclable Antibacterial Agent
Tian, T., Shi, X., Cheng, L., Luo, Y., Dong, Z., Gong, H., Xu, L., Zhong, Z., Peng, R., & Liu, Z. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5022914 · Cited by 205
Response of Escherichia coli growth rate to osmotic shock
Rojas, E., Theriot, J. A., & Huang, K. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402591111 · Cited by 198
Qi, G., Li, L., Yu, F., & Wang, H. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am403940d · Cited by 192
Shifting and non-shifting fluorescence emitted by carbon nanodots
Long, Y.-M., Zhou, C.-H., Zhang, Z.-L., Tian, Z.-Q., Bao, L., Lin, Y., & Pang, D.-W. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm30639e · Cited by 186
Wang, Y., Ding, X., Chen, Y., Guo, M., Zhang, Y., Guo, X., & Gu, H. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.004 · Cited by 183
Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers
Pierrat, P., Wang, R., Kereselidze, D., Lux, M., Didier, P., Kichler, A., Pons, F., & Lebeau, L. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.017 · Cited by 181
Identification of Bacteria in Water by a Fluorescent Array
Chen, W., Li, Q., Zheng, W., Hu, F., Zhang, G., Wang, Z., Zhang, D., & Jiang, X. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201407606 · Cited by 179
Zhang, X., Chen, X., Yang, J., Jia, H., Li, Y., Chen, Z., & Wu, F. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201602185 · Cited by 173
Self-citationGao, J., Li, L., Ho, P. ‐., Mak, G. C., Gu, H., & Xu, B. (2006) · Advanced Materials · doi:10.1002/adma.200601058 · Cited by 171
Nanomaterials for the Treatment of Bacterial Biofilms
Wang, L., Gupta, A., & Rotello, V. M. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00116 · Cited by 156
Zhong, D., Zhuo, Y., Feng, Y., & Yang, X. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.07.015 · Cited by 149
Wang, J., Zhang, Z., Zha, S., Zhu, Y., Wu, P., Ehrenberg, B., & Chen, J.-Y. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.063 · Cited by 149
Structure-activity correlations for antibacterial agents on gram-positive and gram-negative cells
Lien, E. J. C., Hansch, C. H., & Anderson, S. M. (1968) · Journal of Medicinal Chemistry · doi:10.1021/jm00309a004 · Cited by 147
Wang, H., Hua, X.-W., Wu, F., Li, B., Liu, P., Gu, N., Wang, Z., & Chen, Z. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01214 · Cited by 128
Self-citationWang, F., Fang, R. H., Luk, B. T., Hu, C. J., Thamphiwatana, S., Dehaini, D., Angsantikul, P., Kroll, A. V., Pang, Z., Gao, W., et al. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201505231 · Cited by 126
Lan, M., Wu, J., Liu, W., Zhang, W., Ge, J., Zhang, H., Sun, J., Zhao, W., & Wang, P. (2012) · Journal of the American Chemical Society · doi:10.1021/ja211570a · Cited by 124
Thamphiwatana, S., Gao, W., Obonyo, M., & Zhang, L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418230111 · Cited by 120
Alternate gram staining technique using a fluorescent lectin
Sizemore, R. K., Caldwell, J., & Kendrick, A. S. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.7.2245-2247.1990 · Cited by 113
Tuning Laccase Catalytic Activity with Phosphate Functionalized Carbon Dots by Visible Light
Li, H., Guo, S., Li, C., Huang, H., Liu, Y., & Kang, Z. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b02386 · Cited by 112
Huang, Y., Zhou, X. H., Zhou, R., Zhang, H., Kang, K., Zhao, M., Peng, Y., Wang, Q., Zhang, H., & Qiu, W. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201400011 · Cited by 84
Tao, Y., Ran, X., Ren, J., & Qu, X. (2014) · Small · doi:10.1002/smll.201400661 · Cited by 74
Molecular Insights into the Adsorption Mechanism of Human β-Defensin-3 on Bacterial Membranes
Lee, J., Jung, S. W., & Cho, A. E. (2016) · Langmuir · doi:10.1021/acs.langmuir.5b04113 · Cited by 72
High-bright fluorescent carbon dots and their application in selective nucleoli staining
Kong, W., Liu, R., Li, H., Liu, J., Huang, H., Liu, Y., & Kang, Z. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb00579a · Cited by 50
Graphene quantum dots as efficient, metal-free, visible -light-active photocatalysts
Ge, J., Lan, M., Liu, W., Jia, Q., Guo, L., Zhou, B., Meng, X., Niu, G., & Wang, P. (2016) · Science China Materials · doi:10.1007/s40843-016-0115-0 · Cited by 45
Cited by
Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control
Liu, Y., Shi, L., Su, L., van der Mei, H. C., Jutte, P. C., Ren, Y., & Busscher, H. J. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00807d · Cited by 737
Jian, H.-J., Wu, R.-S., Lin, T.-Y., Li, Y.-J., Lin, H.-J., Harroun, S. G., Lai, J.-Y., & Huang, C.-C. (2017) · ACS Nano · doi:10.1021/acsnano.7b01023 · Cited by 507
Self-citationGao, G., Jiang, Y.-W., Jia, H.-R., & Wu, F.-G. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.045 · Cited by 485
Self-citationApplications of carbon dots in environmental pollution control: A review
Long, C., Jiang, Z., Shangguan, J., Qing, T., Zhang, P., & Feng, B. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.126848 · Cited by 434
Recent Advances in Synthesis, Optical Properties, and Biomedical Applications of Carbon Dots
Anwar, S., Ding, H., Xu, M., Hu, X., Li, Z., Wang, J., Liu, L., Jiang, L., Wang, D., Dong, C., et al. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00112 · Cited by 367
Metadata
- Authors
- Yang, J., Zhang, X., Ma, Y.-H., Gao, G., Chen, X., Jia, H.-R., Li, Y.-H., Chen, Z., & Wu, F.-G.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-11-15
- Volume
- 8
- Issue
- 47
- Pages
- 32170-32181
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2543019442
- Cited by
- 409
- References
- 55
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
