The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Multicopper Laccase Mimicking Nanozymes with Nucleotides as Ligands
Abstract
Using nanomaterials to achieve functional enzyme mimics (nanozymes) is attractive for both applied and fundamental research. Laccases are multicopper oxidases highly important for biotechnology and environmental remediation. In this work, we report an exceptionally simple yet functional laccase mimic based on guanosine monophosphate (GMP) coordinated copper. It forms an amorphous metal–organic framework (MOF) material. The ratio of copper and GMP is 3:4 as determined by isothermal titration calorimetry. It has excellent laccase-like activity and converts a diverse range of phenol containing substrates such as hydroquinone, naphthol, catechol and epinephrine. Comparative work shows that the activity is originated from guanosine coordination instead of phosphate binding in GMP. Cu 2+ is required and cannot be substituted by other metal ions. At the same mass concentration, the Cu/GMP nanozyme has a higher V max and similar K m compared to the protein laccase. To achieve the same catalytic efficiency, the cost of the Gu/GMP is ∼2400-fold lower than that of laccase. The Cu/GMP is much more stable at extreme pH, high salt, high temperature and for long-term storage. This is one of the first laccase-mimicking nanozymes, which will find important applications in analytical chemistry, environmental protection, and biotechnology.
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Cites
The Chemistry and Applications of Metal-Organic Frameworks
Furukawa, H., Cordova, K. E., O’Keeffe, M., & Yaghi, O. M. (2013) · Science · doi:10.1126/science.1230444 · Cited by 16,945
Functional Porous Coordination Polymers
Kitagawa, S., Kitaura, R., & Noro, S. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200300610 · Cited by 11,071
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Metal–Organic Frameworks for Separations
Li, J.-R., Sculley, J., & Zhou, H.-C. (2012) · Chemical Reviews · doi:10.1021/cr200190s · Cited by 6,323
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Protein–inorganic hybrid nanoflowers
Ge, J., Lei, J., & Zare, R. N. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.80 · Cited by 1,200
Cation-Triggered Drug Release from a Porous Zinc−Adeninate Metal−Organic Framework
An, J., Geib, S. J., & Rosi, N. L. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902972w · Cited by 1,076
Chen, Z., Yin, J.-J., Zhou, Y.-T., Zhang, Y., Song, L., Song, M., Hu, S., & Gu, N. (2012) · ACS Nano · doi:10.1021/nn300291r · Cited by 940
Jv, Y., Li, B., & Cao, R. (2010) · Chemical Communications · doi:10.1039/c0cc02698k · Cited by 936
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Cited by
Molecular Imprinting on Inorganic Nanozymes for Hundred-fold Enzyme Specificity
Zhang, Z., Zhang, X., Liu, B., & Liu, J. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b00601 · Cited by 666
Self-citationZhang, L., Liu, Z., Deng, Q., Sang, Y., Dong, K., Ren, J., & Qu, X. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202012487 · Cited by 357
Chong, Y., Liu, Q., & Ge, C. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101076 · Cited by 339
Metal–organic framework based nanozymes: promising materials for biochemical analysis
Niu, X., Li, X., Lyu, Z., Pan, J., Ding, S., Ruan, X., Zhu, W., Du, D., & Lin, Y. (2020) · Chemical Communications · doi:10.1039/d0cc04890a · Cited by 328
Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts
Ma, L., Jiang, F., Fan, X., Wang, L., He, C., Zhou, M., Li, S., Luo, H., Cheng, C., & Qiu, L. (2020) · Advanced Materials · doi:10.1002/adma.202003065 · Cited by 298
Metadata
- Authors
- Liang, H., Lin, F., Zhang, Z., Liu, B., Jiang, S., Yuan, Q., & Liu, J.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-01-05
- Volume
- 9
- Issue
- 2
- Pages
- 1352-1360
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2561103237
- Cited by
- 537
- References
- 49
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liang, H., Lin, F., Zhang, Z., Liu, B., Jiang, S., Yuan, Q., & Liu, J. (2017). Multicopper Laccase Mimicking Nanozymes with Nucleotides as Ligands. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.6b15124
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