The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Synergistic Cisplatin/Doxorubicin Combination Chemotherapy for Multidrug-Resistant Cancer via Polymeric Nanogels Targeting Delivery
Abstract
Combination chemotherapy has been proposed to achieve synergistic effect and minimize drug dose for cancer treatment in clinic application. In this article, the stimuli-responsive polymeric nanogels (<100 nm in size) based on poly(acrylic acid) were designed as codelivery system for doxorubicin and cisplatin to overcome drug resistance. By chelation, electrostatic interaction, and π-π stacking interactions, the nanogels could encapsulate doxorubicin and cisplatin with designed ratio and high capacity. Compared with free drugs, the nanogels could deliver more drugs into MCF-7/ADR cells. Significant accumulation in tumor tissues was observed in the biodistribution experiments. The in vitro antitumor studies demonstrated the superior cell-killing activity of the nanogel drug delivery system with a combination index of 0.84, which indicated the great synergistic effect. All the antitumor experimental data revealed that the combination therapy was effective for the multidrug-resistant MCF-7/ADR tumor with reduced side effects.
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Cites
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Cellular processing of platinum anticancer drugs
Wang, D., & Lippard, S. J. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1691 · Cited by 3,801
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
Glutathione in Cancer Biology and Therapy
Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041
Cited by
Applications of π-π stacking interactions in the design of drug-delivery systems
Zhuang, W.-R., Wang, Y., Cui, P.-F., Xing, L., Lee, J., Kim, D., Jiang, H.-L., & Oh, Y.-K. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.014 · Cited by 508
Toxicity of Doxorubicin (Dox) to different experimental organ systems
Pugazhendhi, A., Edison, T. N. J. I., Velmurugan, B. K., Jacob, J. A., & Karuppusamy, I. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.03.023 · Cited by 452
Advances in Our Understanding of the Molecular Mechanisms of Action of Cisplatin in Cancer Therapy
Tchounwou, P. B., Dasari, S., Noubissi, F. K., Ray, P., & Kumar, S. (2021) · Journal of Experimental Pharmacology · doi:10.2147/jep.s267383 · Cited by 384
Trackable Mitochondria-Targeting Nanomicellar Loaded with Doxorubicin for Overcoming Drug Resistance
Zhang, Y., Zhang, C., Chen, J., Liu, L., Hu, M., Li, J., & Bi, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b07219 · Cited by 109
Cellular landscaping of cisplatin resistance in cervical cancer
Bhattacharjee, R., Dey, T., Kumar, L., Kar, S., Sarkar, R., Ghorai, M., Malik, S., Jha, N. K., Vellingiri, B., Kesari, K. K., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113345 · Cited by 93
Metadata
- Authors
- Wu, H., Jin, H., Wang, C., Zhang, Z., Ruan, H., Sun, L., Yang, C., Li, Y., Qin, W., & Wang, C.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-03-08
- Volume
- 9
- Issue
- 11
- Pages
- 9426-9436
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2594622216
- Cited by
- 159
- References
- 4
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wu, H., Jin, H., Wang, C., Zhang, Z., Ruan, H., Sun, L., Yang, C., Li, Y., Qin, W., & Wang, C. (2017). Synergistic Cisplatin/Doxorubicin Combination Chemotherapy for Multidrug-Resistant Cancer via Polymeric Nanogels Targeting Delivery. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.6b16844
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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