Building stable MMP2-responsive multifunctional polymeric micelles by an all-in-one polymer–lipid conjugate for tumor-targeted intracellular drug delivery

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · see citing works

New functions for the matrix metalloproteinases in cancer progression

Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108 · see citing works

Multidrug resistance in cancer: role of ATP–dependent transporters

Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536 · see citing works

Impact of Nanotechnology on Drug Delivery

Farokhzad, O. C., & Langer, R. (2009) · ACS Nano · doi:10.1021/nn900002m · Cited by 3,364 · see citing works

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

Schwarze, S. R., Ho, A. L., Vocero-Akbani, A. M., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,418 · see citing works

PEGylation, successful approach to drug delivery

Veronese, F. M., & Pasut, G. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03575-0 · Cited by 2,344 · see citing works

Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910 · see citing works

Spheroid-based drug screen: Considerations and practical approach

Friedrich, J., Seidel, C., Ebner, R., & Kunz-Schughart, L. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.226 · Cited by 1,742 · see citing works

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,674 · see citing works

Pharmacokinetics and Biodistribution of Nanoparticles

Li, S., & Huang, L. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800049w · Cited by 1,570 · see citing works

The role of interparticle and external forces in nanoparticle assembly

Min, Y., Akbulut, M. E. S., Kristiansen, K. D. L., Golan, Y., & Israelachvili, J. N. (2008) · Nature Materials · doi:10.1038/nmat2206 · Cited by 1,182 · see citing works

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

Mehta, G., Hsiao, A. Y., Ingram, M., Luker, G. D., & Takayama, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.045 · Cited by 1,172 · see citing works

Advanced drug delivery devices via self-assembly of amphiphilic block copolymers

Rösler, A., Vandermeulen, G. W. M., & Klok, H. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00222-8 · Cited by 1,169 · see citing works

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

Gabizón, A., & Papahadjopoulos, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6949 · Cited by 1,134 · see citing works

Mechanisms of Cellular Uptake of Cell-Penetrating Peptides

Madani, F., Lindberg, S., Langel, Ü., Futaki, S., & Gräslund, A. (2011) · Journal of Biophysics · doi:10.1155/2011/414729 · Cited by 986 · see citing works

Solid stress inhibits the growth of multicellular tumor spheroids

Helmlinger, G., Netti, P. A., Lichtenbeld, H. C., Melder, R. J., & Jain, R. K. (1997) · Nature Biotechnology · doi:10.1038/nbt0897-778 · Cited by 859 · see citing works

Is there new hope for therapeutic matrix metalloproteinase inhibition?

Vandenbroucke, R. E., & Libert, C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4390 · Cited by 840 · see citing works

Tumor imaging by means of proteolytic activation of cell-penetrating peptides

Jiang, T., Olson, E. S., Nguyen, Q. T., Roy, M., Jennings, P. A., & Tsien, R. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408191101 · Cited by 823 · see citing works

Cell-penetrating peptides: mechanism and kinetics of cargo delivery

Zorko, M., & Langel, Ü. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.10.010 · Cited by 799 · see citing works

Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs

Lukyanov, A. N., & Torchilin, V. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.12.004 · Cited by 654 · see citing works

Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

GUPTA, B., Levchenko, T. S., & Torchilin, V. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.10.007 · Cited by 632 · see citing works

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

Olson, E. S., Jiang, T., Aguilera, T. A., Nguyen, Q. T., Ellies, L. G., Scadeng, M., & Tsien, R. Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910283107 · Cited by 566 · see citing works

Predicting drug sensitivity and resistance

Szakács, G., Annereau, J., Lababidi, S., Shankavaram, U. T., Arciello, A., Bussey, K. J., Reinhold, W. C., Guo, Y., Kruh, G. D., Reimers, M., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.026 · Cited by 533 · see citing works

Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting

Zhu, L., Kate, P., & Torchilin, V. P. (2012) · ACS Nano · doi:10.1021/nn300524f · Cited by 496 · see citing works

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival

Nguyen, Q. T., Olson, E. S., Aguilera, T. A., Jiang, T., Scadeng, M., Ellies, L. G., & Tsien, R. Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910261107 · Cited by 474 · see citing works

Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety

Zhu, L., Wang, T., Perche, F., Taigind, A., & Torchilin, V. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304987110 · Cited by 360 · see citing works

pH-sensitive poly (histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery

Wu, H., Zhu, L., & Torchilin, V. P. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.072 · Cited by 355 · see citing works

Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.

Schmalfeldt, B., Prechtel, D., Härting, K., Späthe, K., Rutke, S., Konik, E., Fridman, R., Berger, U., Schmitt, M., Kuhn, W. C., et al. (2001) · PubMed · Cited by 334 · see citing works

Patterns of MMP-2 and MMP-9 expression in human cancer cell lines

Niedzwiecki (2009) · Oncology Reports · doi:10.3892/or_00000358 · Cited by 244 · see citing works

Emerging Significance of Flavonoids as P-Glycoprotein Inhibitors in Cancer Chemotherapy

Bansal, T., Jaggi, M., Khar, R. K., & Talegaonkar, S. (2009) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3rc77 · Cited by 240 · see citing works

Hypoxia‐Targeted siRNA Delivery

Perche, F., Biswas, S., Wang, T., Zhu, L., & Torchilin, V. P. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308368 · Cited by 236 · see citing works

TAT Peptide Internalization: Seeking the Mechanism of Entry

Vivès, É., Richard, J., Rispal, C., & Lebleu, B. (2003) · Current Protein and Peptide Science · doi:10.2174/1389203033487306 · Cited by 225 · see citing works

Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs

Zhu, L., Perche, F., Wang, T., & Torchilin, V. P. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.060 · Cited by 220 · see citing works

The Pharmacokinetics of Cell-Penetrating Peptides

Sarko, D., Beijer, B., Boy, R. G., Nothelfer, E.-M., Leotta, K., Eisenhut, M., Altmann, A., Haberkorn, U., & Mier, W. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100223d · Cited by 199 · see citing works

Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines In Vitro: A Comparison of Docetaxel-Loaded Block Copolymer Micelles and Taxotere®

Mikhail, A. S., Eetezadi, S., & Allen, C. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062630 · Cited by 145 · see citing works

The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors

Sarısözen, C., Abouzeid, A. H., & Torchilin, V. P. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.07.001 · Cited by 145 · see citing works

Expression levels of vascular endothelial growth factor, matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteinases 1 and 2 in the plasma of patients with ovarian carcinoma

Manenti, L., Paganoni, P., Floriani, I., Landoni, F., Torri, V., Buda, A. A., Taraboletti, G., Labianca, R., Belotti, D., & Giavazzi, R. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00427-1 · Cited by 101 · see citing works

PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression

Chen, J., Lu, L., Feng, Y., Wang, H., Dai, L., Li, Y., & Zhang, P. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.09.005 · Cited by 82 · see citing works

MMP2-Sensitive PEG–Lipid Copolymers: A New Type of Tumor-Targeted P-Glycoprotein Inhibitor

Dai, Z., Yao, Q., & Zhu, L. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b03064 · Cited by 70 · see citing works

Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate

Tu, Y., & Zhu, L. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.024 · Cited by 65 · see citing works

Zymographic analysis of circulating and tissue forms of colon carcinoma gelatinase A (MMP-2) and B (MMP-9) separated by mono- and two-dimensional electrophoresis

Pucci‐Minafra, I., Minafra, S., Rocca, G. L., et al. (2001) · Matrix Biology · doi:10.1016/s0945-053x(01)00146-9 · Cited by 60 · see citing works

Cremophor-free intravenous microemulsions for paclitaxelII. Stability, in vitro release and pharmacokinetics

Nornoo, A. O., & Chow, D. S. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.07.043 · Cited by 57 · see citing works

Values of MMP-2 and MMP-9 in Tumor Tissue of Basal-Like Breast Cancer Patients

Radenković, S., Konjević, G. M., Jurišić, V., et al. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9701-x · Cited by 49 · see citing works

Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach

Loessner, D., Flegg, J. A., Byrne, H. M., Clements, J. A., & Hutmacher, D. W. (2013) · Integrative Biology · doi:10.1039/c3ib20252f · Cited by 47 · see citing works

Type IV collagenase/gelatinase (MMP-2) is not increased in plasma of patients with cancer.

Zucker, S., Lysik, R. M., Zarrabi, M. H., et al. (1993) · PubMed · Cited by 33 · see citing works

Multifunctional Micellar Nanocarriers for Tumor-Targeted Delivery of Hydrophobic Drugs

Dai, Z., Tu, Y., & Zhu, L. (2016) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2016.2249 · Cited by 31 · see citing works

Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works

Review on overview of colon targeting drug dilivery system

Mahajan, K., Thakur, N., Thakur, K., et al. (2021) · Journal of Emerging Technologies and Innovative Research

Review On Targeted Drug Delivery System And Its Carriers As Drug Targeted To A Specific Organ

-, M. G. M., -, P. P. S., -, K. S. B., et al. (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i02.1973

Polymeric micelles as new drug carriers

Kwon, G. S., & Okano, T. (1996) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00401-2 · Cited by 711 · see citing works

Research and Application of Oral Colon Targeted Drug Delivery System

Bi, Y. S., Zhang, X. X., Cao, X., et al. (2014) · Advanced materials research · doi:10.4028/www.scientific.net/amr.1053.456 · Cited by 4 · see citing works

Delivering more for less: nanosized, minimal-carrier and pharmacoactive drug delivery systems

Etter, E. L., Mei, K., & Nguyen, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113994 · Cited by 102 · see citing works