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Progress and Trends in AIE-Based Bioprobes: A Brief Overview

Mei, Ju, Huang, Youhong, Tian, He·2018·ACS Applied Materials & Interfaces

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Abstract

Luminescent bioprobes are powerful analytical means for biosensing and optical imaging. Luminogens featured with aggregation-induced emission (AIE) attributes have emerged as ideal building blocks for high-performance bioprobes. Bioprobes constructed with AIE luminogens have been identified to be a novel class of FL light-up probing tools. In contrast to conventional bioprobes based on the luminophores with aggregation-caused quenching (ACQ) effect, the AIE-based bioprobes enjoy diverse superiorities, such as lower background, higher signal-to-noise ratio and sensitivity, better accuracy, and more outstanding resistance to photobleaching. AIE-based bioprobes have been tailored for a vast variety of purposes ranging from biospecies sensing to bioimaging to theranostics (i.e., image-guided therapies). In this review, recent five years' advances in AIE-based bioprobes are briefly overviewed in a perspective distinct from other reviews, focusing on the most appealing trends and progresses in this flourishing research field. There are altogether 11 trends outlined, which have been classified into four aspects: the probe composition and form (bioconjugtes, nanoprobes), the output signal of probe (far-red/near-infrared luminescence, two/three-photon excited fluorescence, phosphorescence), the modality and functionality of probing system (dual-modality, dual/multifunctionality), the probing object and application outlet (specific organelles, cancer cells, bacteria, real samples). Typical examples of each trend are presented and specifically demonstrated. Some important prospects and challenges are pointed out as well in the hope of intriguing more interests from researchers working in diverse areas into this exciting research field.

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Cheng, Y., Sun, C., Ou, X., Liu, B., Lou, X., & Xia, F. (2017) · Chemical Science · doi:10.1039/c7sc00402h · Cited by 120
Highly Fluorescent and Photostable Probe for Long‐Term Bacterial Viability Assay Based on Aggregation‐Induced Emission
Zhao, E., Hong, Y., Chen, S., Leung, C. W. T., Chan, C. Y. K., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2013) · Advanced Healthcare Materials · doi:10.1002/adhm.201200475 · Cited by 117
A Photostable Far-Red/Near-Infrared Conjugated Polymer Photosensitizer with Aggregation-Induced Emission for Image-Guided Cancer Cell Ablation
Wu, W., Feng, G., Xu, S., & Liu, B. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b00958 · Cited by 114
Cell Membrane Tracker Based on Restriction of Intramolecular Rotation
Zhang, C., Jin, S., Yang, K., Xue, X., Li, Z., Jiang, Y., Chen, W., Dai, L., Zou, G., & Liang, X. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5025897 · Cited by 111
Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics
Zhang, W., Kwok, R. T. K., Chen, Y., Chen, S., Zhao, E., Yu, C. Y. Y., Lam, J. W. Y., Zheng, Q., & Tang, B. Z. (2015) · Chemical Communications · doi:10.1039/c5cc02486b · Cited by 110
Rational design of metallophosphors with tunable aggregation-induced phosphorescent emission and their promising applications in time-resolved luminescence assay and targeted luminescence imaging of cancer cells
Liu, S., Sun, H., Ma, Y., Ye, S., Liu, X., Zhou, X., Mou, X., Wang, L., Zhao, Q., & Huang, W. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm34512a · Cited by 108
Mapping Live Cell Viscosity with an Aggregation‐Induced Emission Fluorogen by Means of Two‐Photon Fluorescence Lifetime Imaging
Chen, S., Hong, Y., Zeng, Y., Sun, Q., Liu, Y., Zhao, E., Bai, G., Qu, J. Y., Hao, J., & Tang, B. Z. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201405658 · Cited by 108
A fluorescent light-up probe with AIE characteristics for specific mitochondrial imaging to identify differentiating brown adipose cells
Gao, M., Sim, C. K., Leung, C. W. T., Hu, Q., Feng, G., Xu, F., Tang, B. Z., & Liu, B. (2014) · Chemical Communications · doi:10.1039/c4cc00452c · Cited by 107
Stable and Size-Tunable Aggregation-Induced Emission Nanoparticles Encapsulated with Nanographene Oxide and Applications in Three-Photon Fluorescence Bioimaging
Zhu, Z., Qian, J., Zhao, X., Qin, W., Hu, R., Zhang, H., Li, D., Xu, Z., Tang, B. Z., & He, S. (2015) · ACS Nano · doi:10.1021/acsnano.5b05606 · Cited by 107
A “turn on” fluorescent probe for heparin and its oversulfated chondroitin sulfate contaminant
Ding, Y., Shi, L., & Wei, H. (2015) · Chemical Science · doi:10.1039/c5sc01675d · Cited by 106
A near-infrared AIEgen for specific imaging of lipid droplets
Kang, M., Gu, X., Kwok, R. T. K., Leung, C. W. T., Lam, J. W. Y., Li, F., & Tang, B. Z. (2016) · Chemical Communications · doi:10.1039/c6cc01797e · Cited by 106
A ratiometric fluorescent system for carboxylesterase detection with AIE dots as FRET donors
Wu, Y., Huang, S., Zeng, F., Wang, J., Yu, C., Huang, J., Xie, H., & Wu, S. (2015) · Chemical Communications · doi:10.1039/c5cc04771d · Cited by 105
AIEgens‐Functionalized Inorganic‐Organic Hybrid Materials: Fabrications and Applications
Li, D., & Yu, J. (2016) · Small · doi:10.1002/smll.201601484 · Cited by 105
Light-up probe based on AIEgens: dual signal turn-on for caspase cascade activation monitoring
Yuan, Y., Zhang, C., Kwok, R. T. K., Mao, D., Tang, B. Z., & Liu, B. (2017) · Chemical Science · doi:10.1039/c6sc04322d · Cited by 102
PEGylation and cell imaging applications of AIE based fluorescent organic nanoparticles via ring-opening reaction
Zhang, X., Zhang, X., Yang, B., Hui, J., Liu, M., Liu, W., Chen, Y., & Wei, Y. (2013) · Polymer Chemistry · doi:10.1039/c3py01272g · Cited by 101
Ultrabright organic dots with aggregation-induced emission characteristics for cell tracking
Feng, G., Tay, C. Y., Chui, Q. X., Liu, R., Tomczak, N., Liu, J., Tang, B. Z., Leong, D. T., & Liu, B. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.023 · Cited by 100
Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE)
Shi, J. R., Deng, Q., Wan, C., Zheng, M., Huang, F., & Tang, B. (2017) · Chemical Science · doi:10.1039/c7sc02189e · Cited by 99
Rational design of fluorescent light-up probes based on an AIE luminogen for targeted intracellular thiol imaging
Yuan, Y., Kwok, R. T. K., Feng, G., Liang, J., Geng, J., Tang, B. Z., & Liu, B. (2013) · Chemical Communications · doi:10.1039/c3cc47585a · Cited by 98
Morphology‐Tailoring of a Red AIEgen from Microsized Rods to Nanospheres for Tumor‐Targeted Bioimaging
Li, Y., Shao, A., Wang, Y., Mei, J., Niu, D., Gu, J., Shi, P., Zhu, W., Tian, H., & Shi, J. (2016) · Advanced Materials · doi:10.1002/adma.201504782 · Cited by 98
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Fluorescent turn-on sensing of bacterial lipopolysaccharide in artificial urine sample with sensitivity down to nanomolar by tetraphenylethylene based aggregation induced emission molecule
Jiang, G., Wang, J., Yang, Y., Zhang, G., Liu, Y., Lin, H., Zhang, G., Li, Y., & Fan, X. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.04.071 · Cited by 98
A targeted theranostic platinum(iv) prodrug containing a luminogen with aggregation-induced emission (AIE) characteristics for in situ monitoring of drug activation
Yuan, Y., Chen, Y., Tang, B. Z., & Liu, B. (2014) · Chemical Communications · doi:10.1039/c3cc49516g · Cited by 97
Mitochondrion‐Specific Live‐Cell Bioprobe Operated in a Fluorescence Turn‐On Manner and a Well‐Designed Photoactivatable Mechanism
Gu, X., Zhao, E., Lam, J. W. Y., Peng, Q., Xie, Y., Zhang, Y., Wong, K. S., Sung, H. H. Y., Williams, I. D., & Tang, B. Z. (2015) · Advanced Materials · doi:10.1002/adma.201503751 · Cited by 96
Fluorescence Turn‐On Sensing of Lectins with Mannose‐Substituted Tetraphenylethenes Based on Aggregation‐Induced Emission
Sanji, T., Shiraishi, K., Nakamura, M., & Tanaka, M. (2010) · Chemistry - An Asian Journal · doi:10.1002/asia.200900430 · Cited by 96
Supramolecular enhancement of aggregation-induced emission and its application in cancer cell imaging
Yu, G., Tang, G., & Huang, F. (2014) · Journal of Materials Chemistry C · doi:10.1039/c4tc01022a · Cited by 96
Diketopyrrolopyrrole-Based Ratiometric/Turn-on Fluorescent Chemosensors for Citrate Detection in the Near-Infrared Region by an Aggregation-Induced Emission Mechanism
Hang, Y., Wang, J., Jiang, T., Lu, N., & Hua, J. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b03715 · Cited by 96
Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy
Jin, G., Feng, G., Qin, W., Tang, B. Z., Liu, B., & Li, K. (2016) · Chemical Communications · doi:10.1039/c5cc07818k · Cited by 95
Mitochondria-targeted aggregation induced emission theranostics: crucial importance of in situ activation
Shin, W. S., Lee, M.-G., Verwilst, P., Lee, J. H., Chi, S.-G., & Kim, J. S. (2016) · Chemical Science · doi:10.1039/c6sc02236g · Cited by 95
A novel method for preparing AIE dye based cross-linked fluorescent polymeric nanoparticles for cell imaging
Zhang, X., Zhang, X., Yang, B., Hui, J., Liu, M., Chi, Z., Liu, S., Xu, J., & Wei, Y. (2013) · Polymer Chemistry · doi:10.1039/c3py01348k · Cited by 94
A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission
Yu, C. Y. Y., Zhang, W., Kwok, R. T. K., Leung, C. W. T., Lam, J. W. Y., & Tang, B. Z. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00319b · Cited by 94
Protease-Responsive Prodrug with Aggregation-Induced Emission Probe for Controlled Drug Delivery and Drug Release Tracking in Living Cells
Cheng, Y., Huang, F., Min, X., Gao, P., Zhang, T., Li, X., Liu, B., Hong, Y., Lou, X., & Xia, F. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02833 · Cited by 94
Dual aggregation-induced emission for enhanced fluorescence sensing of furin activity in vitro and in living cells
Liu, X., & Liang, G. (2016) · Chemical Communications · doi:10.1039/c6cc09106g · Cited by 94
Targeted theranostic prodrugs based on an aggregation-induced emission (AIE) luminogen for real-time dual-drug tracking
Yuan, Y., Kwok, R. T. K., Zhang, R., Tang, B. Z., & Liu, B. (2014) · Chemical Communications · doi:10.1039/c4cc05255b · Cited by 92
Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation‐Induced Emission for Evaluation of Blood–Brain Barrier Damage
Cai, X., Bandla, A., Mao, D., Feng, G., Qin, W., Liao, L., Thakor, N. V., Tang, B. Z., & Liu, B. (2016) · Advanced Materials · doi:10.1002/adma.201601191 · Cited by 92
Selenocysteine detection and bioimaging in living cells by a colorimetric and near-infrared fluorescent turn-on probe with a large stokes shift
Li, M., Feng, W., Zhai, Q., & Feng, G. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.09.056 · Cited by 92
Biotin-decorated fluorescent silica nanoparticles with aggregation-induced emission characteristics: fabrication, cytotoxicity and biological applications
Li, M., Lam, J. W. Y., Mahtab, F., Chen, S., Zhang, W., Hong, Y., Xiong, J. J., Zheng, Q., & Tang, B. Z. (2012) · Journal of Materials Chemistry B · doi:10.1039/c2tb00155a · Cited by 91
Near-infrared fluorescence amplified organic nanoparticles with aggregation-induced emission characteristics for in vivo imaging
Geng, J., Zhu, Z., Qin, W., Ma, L., Hu, Y., Gurzadyan, G. G., Tang, B. Z., & Liu, B. (2013) · Nanoscale · doi:10.1039/c3nr04243j · Cited by 90
Biocompatible Green and Red Fluorescent Organic Dots with Remarkably Large Two-Photon Action Cross Sections for Targeted Cellular Imaging and Real-Time Intravital Blood Vascular Visualization
Xiang, J., Cai, X., Lou, X., Feng, G., Min, X., Luo, W., He, B., Goh, C. C., Ng, L. G., Zhou, J. Q., et al. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b03766 · Cited by 90
Construction of Supramolecular Nanoassembly for Responsive Bacterial Elimination and Effective Bacterial Detection
Li, Q., Wu, Y., Lu, H., Wu, X., Chen, S., Song, N., Yang, Y., & Gao, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b00873 · Cited by 90
An AIE and ESIPT based kinetically resolved fluorescent probe for biothiols
Cui, L., Baek, Y., Lee, S., Kwon, N., & Yoon, J. (2015) · Journal of Materials Chemistry C · doi:10.1039/c5tc03272e · Cited by 89
Visualization of drug delivery processes using AIEgens
Yuan, Y., & Liu, B. (2017) · Chemical Science · doi:10.1039/c6sc05421h · Cited by 89
A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic–chemotherapy against cisplatin resistant cancer cells
Yuan, Y., Zhang, C., & Liu, B. (2015) · Chemical Communications · doi:10.1039/c5cc01952d · Cited by 87
Rational design for enhancing inflammation-responsive in vivo chemiluminescence via nanophotonic energy relay to near-infrared AIE-active conjugated polymer
Seo, Y. H., Singh, A., Cho, H.-J., Kim, Y., Heo, J., Lim, C., Park, S. Y., Jang, W., & Kim, S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.038 · Cited by 87
A red-emissive antibody–AIEgen conjugate for turn-on and wash-free imaging of specific cancer cells
Shi, X., Yu, C. Y. Y., Su, H., Kwok, R. T. K., Jiang, M., He, Z., Lam, J. W. Y., & Tang, B. Z. (2017) · Chemical Science · doi:10.1039/c7sc01054k · Cited by 87
A FRET probe with AIEgen as the energy quencher: dual signal turn-on for self-validated caspase detection
Yuan, Y., Zhang, R., Cheng, X., Xu, S., & Liu, B. (2016) · Chemical Science · doi:10.1039/c6sc00055j · Cited by 85
Real‐Time Imaging of Cell Behaviors in Living Organisms by a Mitochondria‐Targeting AIE Fluorogen
Situ, B., Chen, S., Zhao, E., Leung, C. W. T., Chen, Y., Hong, Y., Lam, J. W. Y., Wen, Z., Liu, W., Zhang, W., et al. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201602865 · Cited by 81
Detection and Monitoring of Amyloid Fibrillation Using a Fluorescence “Switch-On” Probe
Pradhan, N., Jana, D., Ghorai, B. K., & Jana, N. R. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b07751 · Cited by 80
Synthesis of Imidazole‐Based AIEgens with Wide Color Tunability and Exploration of their Biological Applications
Song, Z., Zhang, W., Jiang, M., Sung, H. H. Y., Kwok, R. T. K., Nie, H., Williams, I. D., Liu, B., & Tang, B. Z. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201503788 · Cited by 79
Emissive nanoparticles from pyridinium-substituted tetraphenylethylene salts: imaging and selective cytotoxicity towards cancer cells in vitro and in vivo by varying counter anions
Huang, Y., Zhang, G., Hu, F., Jin, Y., Zhao, R., & Zhang, D. (2016) · Chemical Science · doi:10.1039/c6sc02395a · Cited by 79
Self-citation
Quencher Group Induced High Specificity Detection of Telomerase in Clear and Bloody Urines by AIEgens
Zhuang, Y., Zhang, M., Chen, B., Duan, R., Min, X., Zhang, Z., Zheng, F., Liang, H., Zhao, Z., Lou, X., et al. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02699 · Cited by 78
Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(iii) complex
Chen, Y., Qiao, L., Yu, B., Li, G., Liu, C., Ji, L., & Chao, H. (2013) · Chemical Communications · doi:10.1039/c3cc46957c · Cited by 78
Electrospun Fibrous Mats with Conjugated Tetraphenylethylene and Mannose for Sensitive Turn-On Fluorescent Sensing of Escherichia coli
Zhao, L., Chen, Y., Yuan, J., Chen, M., Zhang, H., & Li, X. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/am507593p · Cited by 78
Long wavelength AIEgen of quinoline-malononitrile
Guo, Z., Shao, A., & Zhu, W. (2015) · Journal of Materials Chemistry C · doi:10.1039/c5tc03369a · Cited by 78
Targeted imaging of EGFR overexpressed cancer cells by brightly fluorescent nanoparticles conjugated with cetuximab
Gao, M., Su, H., Lin, G., Li, S., Yu, X., Qin, A., Zhao, Z., Zhang, Z., & Tang, B. Z. (2016) · Nanoscale · doi:10.1039/c6nr04439e · Cited by 78
The rational design of a gemcitabine prodrug with AIE-based intracellular light-up characteristics for selective suppression of pancreatic cancer cells
Han, H., Jin, Q., Wang, Y., Chen, Y., & Ji, J. (2015) · Chemical Communications · doi:10.1039/c5cc06654a · Cited by 77
Polyion complex micellar nanoparticles for integrated fluorometric detection and bacteria inhibition in aqueous media
Li, Y., Hu, X., Tian, S., Li, Y., Zhang, G., Zhang, G., & Liu, S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.077 · Cited by 77
Sugar−Phosphole Oxide Conjugates as “Turn-on” Luminescent Sensors for Lectins
Sanji, T., Shiraishi, K., & Tanaka, M. (2008) · ACS Applied Materials & Interfaces · doi:10.1021/am800224r · Cited by 76
Light-up bioprobe with aggregation-induced emission characteristics for real-time apoptosis imaging in target cancer cells
Ding, D., Liang, J., Shi, H., Kwok, R. T. K., Gao, M., Feng, G., Yuan, Y., Tang, B. Z., & Liu, B. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21495h · Cited by 75
Sugar-bearing tetraphenylethylene: novel fluorescent probe for studies of carbohydrate–protein interaction based on aggregation-induced emission
Wang, J., Chen, Q., Bian, N., Yang, F., Sun, J., Qi, A., Yan, C., & Han, B. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/c0ob00680g · Cited by 74
A fluorescent assay for γ-glutamyltranspeptidase via aggregation induced emission and its applications in real samples
Hou, X., Zeng, F., & Wu, S. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.05.036 · Cited by 73
Self-assembled nanomaterials for photoacoustic imaging
Wang, L., Yang, P., Zhao, X., & Wang, H. (2015) · Nanoscale · doi:10.1039/c5nr07437a · Cited by 70
Ratiometric fluorescent response of electrospun fibrous strips for real-time sensing of alkaline phosphatase in serum
Zhao, L., Xie, S., Song, X., Wei, J., Zhang, Z., & Li, X. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.12.025 · Cited by 68
Dual-Modal MRI Contrast Agent with Aggregation-Induced Emission Characteristic for Liver Specific Imaging with Long Circulation Lifetime
Chen, Y., Li, M., Hong, Y., Lam, J. W. Y., Qichang, Z., & Tang, B. Z. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am502282f · Cited by 67
A highly sensitive and facile graphene oxide-based nucleic acid probe: Label-free detection of telomerase activity in cancer patient's urine using AIEgens
Ou, X., Fan, H. B., Zhang, Z., Cheng, Y., Zhao, Z., Gao, P., Lou, X., Xia, F., & Wang, S. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.05.035 · Cited by 67
Fluorescent Strips of Electrospun Fibers for Ratiometric Sensing of Serum Heparin and Urine Trypsin
Zhao, L., Wang, T., Wu, Q., Liu, Y., Chen, Z., & Li, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b14118 · Cited by 67
Tetraphenylethylene‐based Glycoconjugate as a Fluorescence “Turn‐On” Sensor for Cholera Toxin
Hu, X., Chen, Q., Wang, J., Cheng, Q., Yan, C., Cao, J., He, Y., & Han, B. (2011) · Chemistry - An Asian Journal · doi:10.1002/asia.201100141 · Cited by 64
Development of tetraphenylethylene-based fluorescent oligosaccharide probes for detection of influenza virus
Kato, T., Kawaguchi, A., Nagata, K., & Hatanaka, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.155 · Cited by 64
Fabrication of Chitosan Nanoparticles with Aggregation‐Induced Emission Characteristics and Their Applications in Long‐Term Live Cell Imaging
Li, M., Hong, Y., Wang, Z., Chen, S., Gao, M., Kwok, R. T. K., Qin, W., Lam, J. W. Y., Qichang, Z., & Tang, B. Z. (2013) · Macromolecular Rapid Communications · doi:10.1002/marc.201200760 · Cited by 64
A Red to Near‐IR Fluorogen: Aggregation‐Induced Emission, Large Stokes Shift, High Solid Efficiency and Application in Cell‐Imaging
Wang, Y., Shi, Y., Wang, Z., Zhu, Z., Zhao, X., Nie, H., Qian, J., Qin, A., Sun, J. Z., & Tang, B. Z. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201600125 · Cited by 64
Fluorescent light-up probe with aggregation-induced emission characteristics for in vivo imaging of cell apoptosis
Shi, H., Zhao, N., Ding, D., Liang, J., Tang, B. Z., & Liu, B. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob41572d · Cited by 62
Ratiometric Fluorescent Bioprobe for Highly Reproducible Detection of Telomerase in Bloody Urines of Bladder Cancer Patients
Zhuang, Y., Xu, Q., Huang, F., Gao, P., Zhao, Z., Lou, X., & Xia, F. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00076 · Cited by 60
Cyclometalated Iridium(III) Complexes as AIE Phosphorescent Probes for Real-Time Monitoring of Mitophagy in Living Cells
Jin, C., Liu, J., Chen, Y., Guan, R., Ouyang, C., Zhu, Y., Ji, L., & Chao, H. (2016) · Scientific Reports · doi:10.1038/srep22039 · Cited by 60
Specific nucleic acid detection based on fluorescent light-up probe from fluorogens with aggregation-induced emission characteristics
Li, Y., Kwok, R. T. K., Tang, B. Z., & Liu, B. (2013) · RSC Advances · doi:10.1039/c3ra41983e · Cited by 59
AIE probes towards biomolecules: the improved selectivity with the aid of graphene oxide
Li, Q., & Li, Z. (2015) · Science China Chemistry · doi:10.1007/s11426-015-5517-4 · Cited by 59
Folic acid-functionalized AIE Pdots based on amphiphilic PCL-b-PEG for targeted cell imaging
Zhang, Y., Chen, Y., Li, X., Zhang, J., Chen, J., Xu, B., Fu, X., & Tian, W. (2014) · Polymer Chemistry · doi:10.1039/c4py00075g · Cited by 58
Conjugated Polymer/Photochromophore Binary Nanococktails: Bistable Photoswitching of Near‐Infrared Fluorescence for In Vivo Imaging
Jeong, K., Park, S., Lee, Y., Lim, C., Kim, J., Chung, B. H., Kwon, I. C., Park, C. R., & Kim, S. (2013) · Advanced Materials · doi:10.1002/adma.201301901 · Cited by 57
Probing sugar–lectin recognitions in the near-infrared region using glyco-diketopyrrolopyrrole with aggregation-induced-emission
Hang, Y., He, X., Yang, L., & Hua, J. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.10.058 · Cited by 54
Gadolinium‐Functionalized Aggregation‐Induced Emission Dots as Dual‐Modality Probes for Cancer Metastasis Study
Li, K., Ding, D., Chandrasekharan, P., Qin, W., Yang, C., Tang, B. Z., & Liu, B. (2013) · Advanced Healthcare Materials · doi:10.1002/adhm.201300135 · Cited by 54
Fabrication of aggregation-induced emission based fluorescent nanoparticles and their biological imaging application: recent progress and perspectives
Yang, B., Zhang, X., Zhang, X., Huang, Z., Wei, Y., & Tao, L. (2015) · Materials Today · doi:10.1016/j.mattod.2015.11.002 · Cited by 52
Silica shelled and block copolymer encapsulated red-emissive AIE nanoparticles with 50% quantum yield for two-photon excited vascular imaging
Geng, J., Goh, C. C., Qin, W., Liu, R., Tomczak, N., Ng, L. G., Tang, B. Z., & Liu, B. (2015) · Chemical Communications · doi:10.1039/c5cc03603h · Cited by 50
Distinct optical and kinetic responses from E/Z isomers of caspase probes with aggregation-induced emission characteristics
Liang, J., Shi, H., Kwok, R. T. K., Gao, M., Yuan, Y., Zhang, W., Tang, B. Z., & Liu, B. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb00405a · Cited by 50
Specific Turn-On Fluorescent Probe with Aggregation-Induced Emission Characteristics for SIRT1 Modulator Screening and Living-Cell Imaging
Wang, Y., Chen, Y., Wang, H., Cheng, Y., & Zhao, X. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01069 · Cited by 50
Aggregation‐Induced Emission Active Probe for Light‐Up Detection of Anionic Surfactants and Wash‐Free Bacterial Imaging
Gao, M., Wang, L., Chen, J., Li, S., Lu, G., Wang, L., Wang, Y., Ren, L., Qin, A., & Tang, B. Z. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201505202 · Cited by 50
Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery
Zhang, C., Zhang, T., Jin, S., Xue, X., Yang, X., Gong, N., Zhang, J., Wang, P. C., Tian, J., Xing, J., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11536 · Cited by 47
Polylysine Crosslinked AIE Dye Based Fluorescent Organic Nanoparticles for Biological Imaging Applications
Liu, M., Zhang, X., Yang, B., Liu, L., Deng, F., Zhang, X., & Wei, Y. (2014) · Macromolecular Bioscience · doi:10.1002/mabi.201400140 · Cited by 46
Specific Light-Up Probe with Aggregation-Induced Emission for Facile Detection of Chymase
Zhang, R., Zhang, C., Feng, G., Hu, F., Wang, J., & Liu, B. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02073 · Cited by 45
A highly fluorescent AIE-active theranostic agent with anti-tumor activity to specific cancer cells
Zhao, Y., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2016) · Nanoscale · doi:10.1039/c5nr08782a · Cited by 44
Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites
Hu, X., Zang, Y., Li, J. X., Chen, G., James, T. D., He, X., & Tian, H. (2016) · Chemical Science · doi:10.1039/c6sc01463a · Cited by 43
Self-citation
Hybridization induced fluorescence turn-on of AIEgen–oligonucleotide conjugates for specific DNA detection
Zhang, R., Kwok, R. T. K., Tang, B. Z., & Liu, B. (2015) · RSC Advances · doi:10.1039/c5ra00322a · Cited by 42
Long-Term Tracking of the Osteogenic Differentiation of Mouse BMSCs by Aggregation-Induced Emission Nanoparticles
Gao, M., Chen, J., Lin, G., Li, S., Wang, L., Qin, A., Zhao, Z., Ren, L., Wang, Y., & Tang, B. Z. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b05471 · Cited by 42
Renewable itaconic acid based cross-linked fluorescent polymeric nanoparticles for cell imaging
Zhang, X., Zhang, X., Yang, B., Yang, Y., & Wei, Y. (2014) · Polymer Chemistry · doi:10.1039/c4py00794h · Cited by 40
Dimethoxy triarylamine-derived terpyridine–zinc complex: a fluorescence light-up sensor for citrate detection based on aggregation-induced emission
Jiang, T., Lu, N., Hang, Y., Yang, J., Mei, J., Wang, J., Hua, J., & Tian, H. (2016) · Journal of Materials Chemistry C · doi:10.1039/c6tc03042d · Cited by 40
Self-citation
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See all 384

Authors: Mei, J., Huang, Y., & Tian, H.
Venue: ACS Applied Materials & Interfaces
Publisher: American Chemical Society (ACS)
Published: 2017-11-15
Volume: 10
Issue: 15
Pages: 12217-12261
ISSN: 1944-8244 (ISSN-L)
1944-8252
DOI: 10.1021/acsami.7b14343
OpenAlex: W2769269523
Cited by: 384
References: 196
FWCI: 19.20
Type: journal article
Language: en
Open access: closed

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Progress and Trends in AIE-Based Bioprobes: A Brief Overview

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