The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Hyaluronic Acid and Polyethylene Glycol Hybrid Hydrogel Encapsulating Nanogel with Hemostasis and Sustainable Antibacterial Property for Wound Healing
Abstract
Immediate hemorrhage control and anti-infection play important roles in the wound management. Besides, a moist environment is also beneficial for wound healing. Hydrogels are promising materials in urgent hemostasis and drug release. However, hydrogels have the disadvantage of rapid release profiles, leading to the exposure to high drug concentrations. In this study, we constructed hybrid hydrogels with rapid hemostasis and sustainable antibacterial property combining aminoethyl methacrylate hyaluronic acid (HA-AEMA) and methacrylated methoxy polyethylene glycol (mPEG-MA) hybrid hydrogels and chlorhexidine diacetate (CHX)-loaded nanogels. The CHX-loaded nanogels (CLNs) were prepared by the enzyme degradation of CHX-loaded lysine-based hydrogels. The HA-AEMA and mPEG-MA hybrid hydrogel loaded with CLNs (labeled as Gel@CLN) displayed a three-dimensional microporous structure and exhibited excellent swelling, mechanical property, and low cytotoxicity. The Gel@CLN hydrogel showed a prolonged release period of CHX over 240 h and the antibacterial property over 10 days. The hemostasis and wound-healing properties were evaluated in vivo using a mouse model. The results showed that hydrogel had the rapid hemostasis capacity and accelerated wound healing. In summary, CLN-loaded hydrogels may be excellent candidates as hemostasis and anti-infection materials for the wound dressing application.
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Cites
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792
PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
Wound Healing Dressings and Drug Delivery Systems: A Review
Boateng, J. S., Matthews, K. H., Stevens, H. N. E., & Eccleston, G. M. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21210 · Cited by 3,049
Hydrogels in regenerative medicine
Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A. (2009) · Advanced Materials · doi:10.1002/adma.200802106 · Cited by 2,703
Biomedical applications of hydrogels: A review of patents and commercial products
Caló, E., & Khutoryanskiy, V. V. (2015) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.11.024 · Cited by 2,634
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Wong, C., Stylianopoulos, T., Cui, J., Martin, J., Chauhan, V. P., Jiang, W., Popović, Z., Jain, R. K., Bawendi, M. G., & Fukumura, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018382108 · Cited by 1,062
Fan, Z., Liu, B., Wang, J., Zhang, S., Lin, Q., Gong, P., Ma, L., & Yang, S. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201304202 · Cited by 812
Mao, C., Xiang, Y., Liu, X., Cui, Z., Yang, X., Yeung, K. W. K., Pan, H., Wang, X., Chu, P. K., & Wu, S. (2017) · ACS Nano · doi:10.1021/acsnano.7b03513 · Cited by 756
Self-citationMishra, S., Webster, P., & Davis, M. E. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00363 · Cited by 730
Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Haemostatic materials for wound healing applications
Guo, B., Dong, R., Liang, Y., & Li, M. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00323-z · Cited by 992
Smart wound dressings for wound healing
Dong, R., & Guo, B. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101290 · Cited by 959
Yang, Y., Liang, Y., Chen, J., Duan, X., & Guo, B. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.014 · Cited by 548
Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering
Xue, X., Hu, Y., Deng, Y., & Su, J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009432 · Cited by 532
Metadata
- Authors
- Zhu, J., Li, F., Wang, X., Yu, J., & Wu, D.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-04-02
- Volume
- 10
- Issue
- 16
- Pages
- 13304-13316
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2797953917
- Cited by
- 373
- References
- 65
- FWCI
- 25.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hyaluronic Acid and Polyethylene Glycol Hybrid Hydrogel Encapsulating Nanogel with Hemostasis and Sustainable Antibacterial Property for Wound Healing. https://app.cochat.ai/papers/10.1021/acsami.7b18927
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- Zhu, J., Li, F., Wang, X., Yu, J., & Wu, D. (2018). Hyaluronic Acid and Polyethylene Glycol Hybrid Hydrogel Encapsulating Nanogel with Hemostasis and Sustainable Antibacterial Property for Wound Healing. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.7b18927
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