Cited by 29Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsSupramolecular Self-Assembly in Materials

A pH-Responsive Amphiphilic Hydrogel Based on Pseudopeptides and Poly(ethylene glycol) for Oral Delivery of Hydrophobic Drugs

Open access
Wang, Shiqi, Attah, Reva, Li, Jiali, Chen, Yitong, Chen, Rongjun·2018·ACS Biomaterials Science & Engineering

Abstract

Oral administration is a noninvasive and convenient drug delivery route most preferred by patients. However, poor stability in the gastrointestinal tract and low bioavailability of hydrophobic drugs has greatly limited their oral administration. To address this problem, we report a pH-responsive, amphiphilic hydrogel drug carrier based on a pseudopeptide poly( l -lysine isophthalamide) (PLP) and poly(ethylene glycol) (PEG). The hydrogels were prepared by a simple N -(3-(dimethylamino)propyl)- N ′-ethyl carbodiimide hydrochloride (EDC)/ N -hydroxysuccinimide (NHS) coupling reaction, and the cross-linking was confirmed by infrared spectroscopy and differential scanning calorimetry analyses. Because of the pH-responsive conformational alteration of PLP, the hydrogels were relatively hydrophobic and collapsed at acidic pH, but became hydrophilic and swollen at neutral pH. The amphiphilicity enabled the hydrogels to well retain and protect hydrophobic model drugs in the simulated gastric fluid, but efficiently release them in the simulated intestinal fluid. These results suggested that the pH-responsive amphiphilic hydrogels are promising candidates for oral delivery of hydrophobic drugs.

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Crossref · 10.1021/acsbiomaterials.8b01040

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Authors
Wang, S., Attah, R., Li, J., Chen, Y., & Chen, R.
Affiliations
Imperial College London (GB)
Corresponding author
Chen, Rongjun
Venue
ACS Biomaterials Science & Engineering
Published
2018-09-24
Volume
4
Issue
12
Pages
4236-4243
ISSN
2373-9878 (ISSN-L)
OpenAlex
W2893966129
Cited by
29
References
46
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 1 · 2019: 5
FWCI
1.14
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • ACS Biomaterials Science & Engineering (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Spiral (Imperial College London) (submittedVersion)
  • Spiral (Imperial College London) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
Keywords
pH-responsive hydrogels, amphiphilic hydrogels, pseudopeptides, polyethylene glycol, oral drug delivery, poorly water-soluble drugs, pH-dependent drug release, hydrogel crosslinking, bioavailability

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