Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters

Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

Galliford, C. V., & Scheidt, K. A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200701342 · Cited by 2,429

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

Singh, G. S., & Desta, Z. Y. (2012) · Chemical Reviews · doi:10.1021/cr300135y · Cited by 1,601

Privileged scaffolds for library design and drug discovery

Welsch, M. E., Snyder, S. A., & Stockwell, B. R. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.02.018 · Cited by 1,509

Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids

Marti, C., & Carreira, E. M. (2003) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200300050 · Cited by 1,455

The use of spirocyclic scaffolds in drug discovery

Zheng, Y., Tice, C. M., & Singh, S. B. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.06.081 · Cited by 1,036

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

Galloway, W. R. J. D., Isidro-Llobet, A., & Spring, D. R. (2010) · Nature Communications · doi:10.1038/ncomms1081 · Cited by 891

Spirooxindoles: Promising scaffolds for anticancer agents

Yu, B., Yu, D.-Q., & Liu, H.-M. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.06.056 · Cited by 867

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

Cheng, D., Ishihara, Y., Tan, B., & Barbas, C. F. (2014) · ACS Catalysis · doi:10.1021/cs401172r · Cited by 856

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules

Liu, Y., Han, S.-J., Liu, W.-B., & Stoltz, B. M. (2015) · Accounts of Chemical Research · doi:10.1021/ar5004658 · Cited by 825

Catalytic Enantioselective Desymmetrization Reactions to All-Carbon Quaternary Stereocenters

Zeng, X.-P., Cao, Z.-Y., Wang, Y.-H., Zhou, F., & Zhou, J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00094 · Cited by 807

Enantioselective methodologies for the synthesis of spiro compounds

Rios, R. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15156h · Cited by 781

Chiral Diphosphine and Monodentate Phosphorus Ligands on a Spiro Scaffold for Transition-Metal-Catalyzed Asymmetric Reactions

Xie, J.-H., & Zhou, Q.-L. (2008) · Accounts of Chemical Research · doi:10.1021/ar700137z · Cited by 774

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′‐Spirocyclic Oxindoles

Hong, L., & Wang, R. (2013) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201200808 · Cited by 718

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

Dalpozzo, R., Bartoli, G., & Bencivenni, G. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35100e · Cited by 673

Structure-based design of potent non-peptide MDM2 inhibitors

Ding, K., Lu, Y., Nikolovska-Coleska, Z., Qiu, S., Ding, Y., Gao, W., Stuckey, J., Krajewski, K., Roller, P. P., Tomita, Y., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja051147z · Cited by 657

Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities

Carreira, E. M., & Fessard, T. C. (2014) · Chemical Reviews · doi:10.1021/cr500127b · Cited by 630

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

Chen, X.-H., Wei, Q., Luo, S.-W., Xiao, H., & Gong, L.-Z. (2009) · Journal of the American Chemical Society · doi:10.1021/ja905302f · Cited by 577

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

Antonchick, A. P., Gerding-Reimers, C., Catarinella, M., Schürmann, M., Preut, H., Ziegler, S., Rauh, D., & Waldmann, H. (2010) · Nature Chemistry · doi:10.1038/nchem.730 · Cited by 569

Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst

Tan, B., Candeias, N. R., & Barbas, C. F. (2011) · Nature Chemistry · doi:10.1038/nchem.1039 · Cited by 466

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

Bencivenni, G., Wu, L., Mazzanti, A., Giannichi, B., Pesciaioli, F., Song, M., Bartoli, G., & Melchiorre, P. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200903192 · Cited by 448

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

Bencivenni, G., Wu, L., Mazzanti, A., Giannichi, B., Pesciaioli, F., Song, M., Bartoli, G., & Melchiorre, P. (2009) · Angewandte Chemie · doi:10.1002/ange.200903192 · Cited by 427

Enantioselective Construction of Spirocyclic Oxindolic Cyclopentanes by Palladium-Catalyzed Trimethylenemethane-[3+2]-Cycloaddition

Trost, B. M., Cramer, N., & Silverman, S. M. (2007) · Journal of the American Chemical Society · doi:10.1021/ja075335w · Cited by 420

Highly Enantioselective [3+2] Annulation of Morita–Baylis–Hillman Adducts Mediated by L‐Threonine‐Derived Phosphines: Synthesis of 3‐Spirocyclopentene‐2‐oxindoles having Two Contiguous Quaternary Centers

Zhong, F., Han, X., Wang, Y., & Lu, Y. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201102094 · Cited by 419

Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclic ortho-Quinodimethanes

Liu, Y., Nappi, M., Arceo, E., Vera, S., & Melchiorre, P. (2011) · Journal of the American Chemical Society · doi:10.1021/ja206517s · Cited by 398

Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Bisphosphine/Au(I) Complex

Cao, Z.-Y., Wang, X., Tan, C., Zhao, X.-L., Zhou, J., & Ding, K. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4040895 · Cited by 363

Spiro Skeletons: A Class of Privileged Structure for Chiral Ligand Design

Ding, K., Han, Z., & Wang, Z. (2008) · Chemistry - An Asian Journal · doi:10.1002/asia.200800192 · Cited by 307

Route to three-dimensional fragments using diversity-oriented synthesis

Hung, A. W., Ramek, A., Wang, Y., Kaya, T., Wilson, J. A., Clemons, P. A., & Young, D. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015271108 · Cited by 268

Asymmetric Synthesis of Spiropyrazolones through Phosphine‐Catalyzed [4+1] Annulation

Han, X., Yao, W., Wang, T., Tan, Y. R., Yan, Z., Kwiatkowski, J., & Lu, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201311214 · Cited by 261

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

Cao, Y., Jiang, X., Liu, L., Shen, F., Zhang, F., & Wang, R. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104216 · Cited by 261

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

Cao, Y., Jiang, X., Liu, L., Shen, F., Zhang, F., & Wang, R. (2011) · Angewandte Chemie · doi:10.1002/ange.201104216 · Cited by 237

Organocatalytic Tandem Reaction to Construct Six‐Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

Jiang, K., Jia, Z., Chen, S., Wu, L., & Chen, Y. (2010) · Chemistry – A European Journal · doi:10.1002/chem.200903009 · Cited by 236

Catalyst‐Controlled Switch in Chemo‐ and Diastereoselectivities: Annulations of Morita–Baylis–Hillman Carbonates from Isatins

Zhan, G., Shi, M., He, Q., Lin, W., Ouyang, Q., Du, W., & Chen, Y. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510825 · Cited by 232

Pd(II)/Brønsted Acid Catalyzed Enantioselective Allylic C–H Activation for the Synthesis of Spirocyclic Rings

Chai, Z., & Rainey, T. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2102407 · Cited by 225

The pharmacology and toxicology of kratom: from traditional herb to drug of abuse

Warner, M. L., Kaufman, N. C., & Grundmann, O. (2016) · International Journal of Legal Medicine · doi:10.1007/s00414-015-1279-y · Cited by 211

An Organocatalytic [3+2] Cyclisation Strategy for the Highly Enantioselective Synthesis of Spirooxindoles

Voituriez, A., Pinto, N., Neel, M., Retailleau, P., & Marinetti, A. (2010) · Chemistry – A European Journal · doi:10.1002/chem.201001791 · Cited by 210

Cycloaddition Reactions in Organic Synthesis

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An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers

Sun, W., Zhu, G., Wu, C., Hong, L., & Wang, R. (2012) · Chemistry – A European Journal · doi:10.1002/chem.201200478 · Cited by 164

Highly diastereo- and enantioselective construction of a spiro[cyclopenta[b]indole-1,3′-oxindole] scaffold via catalytic asymmetric formal [3+2] cycloadditions

Tan, W., Li, X., Gong, Y.-X., Ge, M.-D., & Shi, F. (2014) · Chem. Commun. · doi:10.1039/c4cc07246d · Cited by 163

Organocatalytic Michael–Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles

Pesciaioli, F., Righi, P., Mazzanti, A., Bartoli, G., & Bencivenni, G. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201003423 · Cited by 157

Diastereo‐ and Enantioselective Construction of a Bispirooxindole Scaffold Containing a Tetrahydro‐β‐carboline Moiety through an Organocatalytic Asymmetric Cascade Reaction

Dai, W., Han, L., Li, X., Shi, F. J., & Tu, S. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201402485 · Cited by 155

PyBidine–Cu(OTf)2‐Catalyzed Asymmetric [3+2] Cycloaddition with Imino Esters: Harmony of Cu–Lewis Acid and Imidazolidine‐NH Hydrogen Bonding in Concerto Catalysis

Arai, T., Ogawa, H., Awata, A., Sato, M., Watabe, M., & Yamanaka, M. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201410782 · Cited by 148

Organocatalytic Diastereo‐ and Enantioselective 1,3‐Dipolar Cycloaddition of Azlactones and Methyleneindolinones

Sun, W., Zhu, G., Wu, C., Li, G., Hong, L., & Wang, R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201302831 · Cited by 145

Catalytic asymmetric synthesis of 3,3-disubstituted oxindoles: diazooxindole joins the field

Cao, Z., Wang, Y., Zeng, X., et al. (2014) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.01.084 · Cited by 145

Diastereodivergent Synthesis of 3‐Spirocyclopropyl‐2‐oxindoles through Direct Enantioselective Cyclopropanation of Oxindoles

Dou, X., & Lü, Y. (2012) · Chemistry - A European Journal · doi:10.1002/chem.201200655 · Cited by 143

Organocatalytic Enamine-Activation of Cyclopropanes for Highly Stereoselective Formation of Cyclobutanes

Halskov, K. S., Kniep, F., Lauridsen, V. H., Iversen, E. H., Donslund, B. S., & Jørgensen, K. A. (2015) · Journal of the American Chemical Society · doi:10.1021/ja512573q · Cited by 141

Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters via Organocatalytic Michael–Henry Cascade Reactions

Albertshofer, K., Tan, B., & Barbas, C. F. (2012) · Organic Letters · doi:10.1021/ol300441z · Cited by 138

Asymmetric Organocatalytic Direct C(sp 2 )H/C(sp 3 )H Oxidative Cross‐Coupling by Chiral Iodine Reagents

Wu, H. Y., He, Y., Xu, L., Zhang, D., & Gong, L. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201309967 · Cited by 137

Catalytic asymmetric 1,3-dipolar cycloaddition of N-unprotected 2-oxoindolin-3-ylidene derivatives and azomethine ylides for the construction of spirooxindole-pyrrolidines

Liu, T., Xue, Z.-Y., Tao, H., & Wang, C. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/c0ob00943a · Cited by 137

Chiral Iodine‐Catalyzed Dearomatizative Spirocyclization for the Enantioselective Construction of an All‐Carbon Stereogenic Center

Zhang, D., Xu, L., Wu, H. Y., & Gong, L. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201501583 · Cited by 131

A Highly Diastereo- and Enantioselective Hg(II)-Catalyzed Cyclopropanation of Diazooxindoles and Alkenes

Cao, Z., Zhou, F., Yu, Y., & Zhou, J. E. (2012) · Organic Letters · doi:10.1021/ol302998m · Cited by 129

Enantiotopos‐Selective CH Oxygenation Catalyzed by a Supramolecular Ruthenium Complex

Frost, J. R., Huber, S. M., Breitenlechner, S., Bannwarth, C., & Bach, T. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201409224 · Cited by 126

An Asymmetric Diels–Alder Reaction Catalyzed by Chiral Phosphate Magnesium Complexes: Highly Enantioselective Synthesis of Chiral Spirooxindoles

Li, G., Liang, T., Wojtas, Ł., & Antilla, J. C. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201209295 · Cited by 124

Highly Efficient Enantioselective Construction of Bispirooxindoles Containing Three Stereocenters through an Organocatalytic Cascade Michael–Cyclization Reaction

Wu, H., Zhang, L., Tian, Z., Huang, Y., & Wang, Y. (2012) · Chemistry - A European Journal · doi:10.1002/chem.201203221 · Cited by 121

Switchable Access to Different Spirocyclopentane Oxindoles by N‐Heterocyclic Carbene Catalyzed Reactions of Isatin‐Derived Enals and N‐Sulfonyl Ketimines

Wang, L., Li, S., Blümel, M., Puttreddy, R., Peuronen, A., Rissanen, K. T., & Enders, D. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201704210 · Cited by 116

An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters

Sun, W., Hong, L., Zhu, G., Wang, Z., Wei, X., Ni, J., & Wang, R. (2014) · Organic Letters · doi:10.1021/ol4034226 · Cited by 115

Catalytic Asymmetric Tamura Cycloadditions

Manoni, F., & Connon, S. J. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201309297 · Cited by 114

Palladium-Catalyzed Asymmetric Cycloadditions of Vinylcyclopropanes and in Situ Formed Unsaturated Imines: Construction of Structurally and Optically Enriched Spiroindolenines

Liu, Z., Li, W.-K., Kang, T., He, L., & Liu, Q. (2014) · Organic Letters · doi:10.1021/ol503383x · Cited by 112

Core Scaffold‐Inspired Concise Synthesis of Chiral Spirooxindole‐Pyranopyrimidines with Broad‐Spectrum Anticancer Potency

Jiang, X., Sun, Y., Yao, J., Cao, Y., Kai, M., He, N., Zhang, X., Wang, Y., & Wang, R. (2012) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201100792 · Cited by 111

Sequential Au( i )/chiral tertiary amine catalysis: a tandem C–H functionalization of anisoles or a thiophene/asymmetric Michael addition sequence to quaternary oxindoles

Cao, Z., Zhao, Y., & Zhou, J. E. (2015) · Chemical Communications · doi:10.1039/c5cc10096h · Cited by 108

Brønsted Acid Catalyzed Asymmetric Diels–Alder Reactions: Stereoselective Construction of Spiro[tetrahydrocarbazole-3,3′-oxindole] Framework

Wang, Y., Tu, M., Yin, L., Sun, M., & Shi, F. J. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b00198 · Cited by 108

Organocatalytic Asymmetric Cascade Reactions of 7‐Vinylindoles: Diastereo‐ and Enantioselective Synthesis of C7‐Functionalized Indoles

Shi, F. J., Zhang, H., Sun, X., Liang, J. L., Fan, T., & Tu, S. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201405245 · Cited by 107

Enantioselective Synthesis of Dihydrospiro[indoline-3,4′-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction

Kumarswamyreddy, N., & Kesavan, V. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b00287 · Cited by 107

3‐Isothiocyanato Oxindoles Serving as Powerful and Versatile Precursors to Structurally Diverse Dispirocyclic Thiopyrrolidineoxindoles through a Cascade Michael/Cyclization Process with Amino‐Thiocarbamate Catalysts

Han, W., Li, S., Wu, Z., Zhang, X., & Yuan, W. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201300206 · Cited by 105

α-Regioselective Asymmetric [3 + 2] Annulations of Morita–Baylis–Hillman Carbonates with Cyclic 1-Azadienes and Mechanism Elucidation

Wang, K., Jin, T., Huang, X., Ouyang, Q., Du, W., & Chen, Y. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b00189 · Cited by 103

Catalytic [4+2] Cyclization of α,β‐Unsaturated Acyl Chlorides with 3‐Alkylenyloxindoles: Highly Diastereo‐ and Enantioselective Synthesis of Spirocarbocyclic Oxindoles

Shen, L., Jia, W., & Ye, S. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201207405 · Cited by 100

Enantioselective 1,3-dipolar cycloaddition of methyleneindolinones and N,N′-cyclic azomethine imines

Hong, L., Kai, M., Wu, C., Sun, W., Zhu, G., Li, G., Yao, X., & Wang, R. (2013) · Chemical Communications · doi:10.1039/c3cc41507d · Cited by 96

Asymmetric Tandem 1,5‐Hydride Shift/Ring Closure for the Synthesis of Chiral Spirooxindole Tetrahydroquinolines

Cao, W., Liu, X., Guo, J., Lin, L., & Feng, X. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201404327 · Cited by 88

Organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with 3-alkenyl-5-arylfuran-2(3H)-ones

Wang, Z., Wu, Z., Yue, D., Hu, W., Zhang, X., Xu, X., & Yuan, W. (2016) · Chemical Communications · doi:10.1039/c6cc06367e · Cited by 88

“Organo–Metal” Synergistic Catalysis: The 1+1>2 Effect for the Construction of Spirocyclopentene Oxindoles

Sun, W., Zhu, G., Wu, C., Hong, L., & Wang, R. (2012) · Chemistry - A European Journal · doi:10.1002/chem.201201976 · Cited by 87

The asymmetric synthesis of polycyclic 3-spirooxindole alkaloids via the cascade reaction of 2-isocyanoethylindoles

Zhao, X., Liu, X., Xiong, Q., Mei, H., Ma, B., Lin, L., & Feng, X. (2015) · Chemical Communications · doi:10.1039/c5cc06353a · Cited by 85

Asymmetric synthesis of trifluoromethyl-substituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions

Huang, W.-J., Chen, Q., Lin, N., Long, X.-W., Pan, W., Xiong, Y., Weng, J., & Lu, G. (2016) · Organic Chemistry Frontiers · doi:10.1039/c6qo00723f · Cited by 85

Hydrogen-Bond-Directed Formal [5 + 1] Annulations of Oxindoles with Ester-Linked Bisenones: Facile Access to Chiral Spirooxindole δ-Lactones

Zhao, S., Lin, J., Zhao, Y.-Y., Liang, Y., & Xu, P. (2014) · Organic Letters · doi:10.1021/ol500547e · Cited by 82

Asymmetric synthesis of 3,3′-pyrrolidinyl-dispirooxindoles via a one-pot organocatalytic Mannich/deprotection/aza-Michael sequence

Zhao, K., Zhi, Y., Li, X., Puttreddy, R., Rissanen, K. T., & Enders, D. (2015) · Chemical Communications · doi:10.1039/c5cc10057g · Cited by 82

Synergistic Catalysis: Enantioselective Ring Expansion of Vinyl Cyclopropanes Combining Four Catalytic Cycles for the Synthesis of Highly Substituted Spirocyclopentanes Bearing up to Four Stereocenters

Meazza, M., & Rios, R. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201601893 · Cited by 82

Highly Stereoselective [3+2] Cycloadditions of Chiral Palladium‐Containing N1‐1,3‐Dipoles: A Divergent Approach to Enantioenriched Spirooxindoles

Li, T., Cheng, B., Fan, S., Wang, Y., Lu, L., & Xiao, W. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201600735 · Cited by 81

Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters

Cui, B., Li, S., Zuo, J., Wu, Z., Zhang, X., & Yuan, W. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.01.036 · Cited by 81

A DFT Study on Rh-Catalyzed Asymmetric Dearomatization of 2-Naphthols Initiated with C–H Activation: A Refined Reaction Mechanism and Origins of Multiple Selectivity

Zheng, C., Zheng, J., & You, S. (2015) · ACS Catalysis · doi:10.1021/acscatal.5b01891 · Cited by 80

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3-Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

Zhang, J., Wang, H., Jin, Q., Zheng, C., Zhao, G., & Shang, Y. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b02098 · Cited by 78

The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides

Yang, W., Liu, Y., Luo, S., Yu, X., Fossey, J., & Deng, W. (2015) · Chemical Communications · doi:10.1039/c5cc02362a · Cited by 75

Diversifying complexity

Sharma, I., & Tan, D. S. (2013) · Nature Chemistry · doi:10.1038/nchem.1581 · Cited by 72

Organocatalytic [4+2] addition reactions via tetraenamine intermediate

Stiller, J., Poulsen, P. H., Cruz, D. C., Dourado, J., Davis, R. L., & Jørgensen, K. A. (2014) · Chemical Science · doi:10.1039/c4sc00081a · Cited by 68

Enantioselective synthesis of the spirotryprostatin A scaffold

Antonchick, A. P., Schuster, H., Bruss, H., Schürmann, M., Preut, H., Rauh, D., & Waldmann, H. (2011) · Tetrahedron · doi:10.1016/j.tet.2011.04.056 · Cited by 68

Highly Enantioselective Control of Dynamic Cascade Transformations by Dual Catalysis: Asymmetric Synthesis of Polysubstituted Spirocyclic Oxindoles

Afewerki, S., Ma, G., Ibrahem, I., Liu, L., Sun, J., & Córdova, A. (2015) · ACS Catalysis · doi:10.1021/cs501975u · Cited by 67

Substrate-controlled switchable asymmetric annulations to access polyheterocyclic skeletons

Wang, K., Wang, P., Ouyang, Q., Du, W., & Chen, Y. (2016) · Chemical Communications · doi:10.1039/c6cc06148f · Cited by 65

Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis

Jia, Z., Shan, G., Daniliuc, C. G., Antonchick, A. P., & Waldmann, H. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201712882 · Cited by 65

Chiral phosphoric acid catalyzed enantioselective 1,3-dipolar cycloaddition reaction of azlactones

Zhang, Z., Sun, W., Zhu, G., Yang, J., Zhang, M., Hong, L., & Wang, R. (2015) · Chemical Communications · doi:10.1039/c5cc08989a · Cited by 62

Enantioselective Construction of Spirocyclic Oxindoles via Tandem Michael/Michael Reactions Catalyzed by Multifunctional Quaternary Phosphonium Salt

Zhang, J., Cao, D., Wang, H., Zheng, C., Zhao, G., & Shang, Y. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b01553 · Cited by 60

Squaramide‐Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites

Sun, Q., Zhu, H., Chen, Y., Yang, X., Sun, X., & Lin, G. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506206 · Cited by 59

Assembly of Spirooxindole Derivatives via Organocatalytic Iminium-Enamine Cascade Reactions

Albertshofer, K., Anderson, K. E., & Barbas, C. F. (2012) · Organic Letters · doi:10.1021/ol302876c · Cited by 58

Asymmetric [3 + 2] Cycloaddition of Methyleneindolinones with N,N′-Cyclic Azomethine Imines Catalyzed by a N,N′-Dioxide–Mg(OTf)2 Complex

Yin, C., Lin, L., Zhang, D., Feng, J., Liu, X., & Feng, X. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b01760 · Cited by 57

Asymmetric Synthesis of 2′‐Trifluoromethylated Spiro‐pyrrolidine‐3,3′‐oxindoles via Squaramide‐Catalyzed Umpolung and 1,3‐Dipolar Cycloaddition

Su, J., Ma, Z., Li, X., Lin, L., Shen, Z., Yang, P., Li, Y., Wang, H., Yan, W., Wang, K., et al. (2016) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201600688 · Cited by 56

Asymmetric Synthesis of Spirocyclic Oxindole‐Fused Tetrahydrothiophenes via N,N′‐Dioxide–Nickel(II) Catalyzed Domino Reaction of 1,4‐Dithiane‐2,5‐diol with 3‐Alkenyloxindoles

Zhou, P., Cai, Y., Lin, L., Lian, X., Xia, Y. M., Liu, X., & Feng, X. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201400964 · Cited by 54

Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway

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An organocatalytic domino Michael-alkylation reaction: highly enantioselective construction of spiro-cyclopentanoneoxindoles and tetronic acid scaffolds

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Chiral N‐Heterocyclic Carbene‐Catalyzed Asymmetric Michael–Intramolecular Aldol‐Lactonization Cascade for Enantioselective Construction of β‐Propiolactone‐Fused Spiro[cyclopentane‐oxindoles]

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Enantioselective Vinylogous Michael/Cyclization Cascade Reaction of Acyclic β,γ‐Unsaturated Amides with Isatylidene Malononitriles: Asymmetric Construction of Spirocyclic Oxindoles

Li, T.-Z., Xie, J., Jiang, Y., Sha, F., & Wu, X. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201500469 · Cited by 49

Catalytic enantioselective cascade Michael/cyclization reaction of 3-isothiocyanato oxindoles with exocyclic α,β-unsaturated ketones en route to 3,2′-pyrrolidinyl bispirooxindoles

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PyBidine–Ni(OAc)2-Catalyzed Michael/Aldol Reaction of Methyleneindolinones and Thiosalicylaldehydes for Stereochemically Divergent Thiochromanyl-spirooxindoles

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Enantioselective Total Synthesis of (+)-Colletoic Acid via Catalytic Asymmetric Intramolecular Cyclopropanation of an α-Diazo-β-keto Diphenylphosphine Oxide

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Enantioselective Construction of Spirooxindole Derivatives through [3+2] Annulation Catalyzed by a Bisthiourea as a Multiple‐Hydrogen‐Bond Donor

Shi, Y., Lin, A., Mao, H., Mao, Z., Li, W., Hu, H., Zhu, C., & Cheng, Y. (2012) · Chemistry - A European Journal · doi:10.1002/chem.201202937 · Cited by 45

Chiral N,N′-dioxide/Co( ii )-promoted asymmetric 1,3-dipolar cycloaddition of nitrones with methyleneindolinones

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N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Spiro-glutarimides via α,β-Unsaturated Acylazoliums

Mondal, S., Ghosh, A., Mukherjee, S., & Biju, A. T. (2018) · Organic Letters · doi:10.1021/acs.orglett.8b01799 · Cited by 43

One‐Pot Organocatalytic Enantioselective Michael/Povarov Domino Strategy for the Construction of Spirooctahydroacridine‐3,3′‐oxindole Scaffolds

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Non‐Covalent Carbonyl‐Directed Heck–Matsuda Desymmetrizations: Synthesis of Cyclopentene‐Fused Spirooxindoles, Spirolactones, and Spirolactams

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Trienamine catalysis with linear deconjugated 3,5-dienones

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Synthesis of Optically Pure Spiro[cyclohexane-oxindoline] Derivatives via Catalytic Asymmetric Diels–Alder Reaction of Brassard-Type Diene with Methyleneindolines

Zheng, J., Lin, L., Fu, K., Zheng, H., Liu, X., & Feng, X. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b01318 · Cited by 37

L-Pyroglutamic Sulphonamide as Hydrogen-Bonding Organocatalyst: Enantioselective Diels–Alder Cyclization to Construct Carbazolespirooxindoles

Ren, J., Wang, J., Xiao, J., Li, J., Xiang, H., Chen, X.-Q., & Yang, H. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b00733 · Cited by 35

Highly Enantioselective Construction of Spirocyclopentaneoxindoles Containing Four Consecutive Stereocenters through an Organocatalytic Iminium–Enamine Cascade Reaction

Liang-zhong, D., Zhong, T., Wu, H., & Wang, Y. (2014) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201402687 · Cited by 32

Organocatalytic Enantioselective Assembly of Spirooxindole‐naphthopyrans through Tandem Friedel–Crafts Type/Hemiketalization

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Organocatalytic tandem enantioselective Michael-cyclization of isatin-derived β,γ-unsaturated α-ketoesters with 3-hydroxy-4H-chromen-4-one or 2-hydroxy-1,4-naphthoquinone derivatives

Yin, S., Zhang, S., Zhang, J., Sun, B.-B., Fan, W., Wu, B., & Wang, X. (2016) · RSC Advances · doi:10.1039/c6ra17400k · Cited by 29

Organocatalytic Enantioselective Synthesis of Polysubstituted Spirooxindoles using a Tandem Michael–Michael Reaction

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Dinuclear zinc-catalyzed desymmetric intramolecular aldolization: an enantioselective construction of spiro[cyclohexanone-oxindole] derivatives

Zhang, Y., Yin, S., Zhao, M., Zhang, J., Li, H., & Wang, X. (2016) · RSC Advances · doi:10.1039/c6ra02296k · Cited by 20

Efficient construction of biologically important functionalized polycyclic spiro-fused carbocyclicoxindoles via an asymmetric organocatalytic quadruple-cascade reaction

Ren, W., Wang, X., Li, J., Tian, M., Liu, J., Ouyang, L., & Wang, J. (2017) · RSC Advances · doi:10.1039/c6ra24910h · Cited by 20

One-Pot Sequential [3 + 3] Dipolar Cycloaddition of Aldehyde or Ketone and Hydroxylamine with Spirocyclopropyl Oxindole

Xu, P., Chen, C., Liu, J.-K., Song, Y., Zhou, F., Yan, J., & Zhou, J. E. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b02208 · Cited by 20

Construction of highly enantioselective spiro-oxindole derivatives with fused chromene via organocascade catalysis

Kumari, P., Nandi, S., Kumar, G., Khan, N. H., Kureshy, R. I., Abdi, S. H. R., Suresh, E., & Bajaj, H. C. (2016) · RSC Advances · doi:10.1039/c6ra06812j · Cited by 17

Organocatalytic asymmetric synthesis of trans -configured trispirooxindoles through a cascade Michael-cyclization reaction

Wu, C., Jing, L., Qin, D., Yin, M., & He, Q. (2016) · Tetrahedron Letters · doi:10.1016/j.tetlet.2016.05.056 · Cited by 15

Enantioselective construction of novel chiral spirooxindoles incorporating a thiazole nucleus

Cui, L.-Y., Wang, Y., & Zhou, Z. (2016) · RSC Advances · doi:10.1039/c6ra14178a · Cited by 14

Cinchona Alkaloid Derived Primary Amine Catalyzed Intramolecular Desymmetrizing Aldolization Reaction of Diacetonyloxindoles

Sun, B., Zhang, Y., Zhang, J., Yin, S., Fan, W., Li, H., & Wang, X. (2017) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201700155 · Cited by 5