Cell-Derived Exosome Therapy: A Novel Approach to Treat Post-traumatic Brain Injury Mediated Neural Injury
Abstract
Traumatic brain injury (TBI) causes serious neuronal injury that often leads to death. To date there is no clinically successful treatment strategy that has been reported which offers repair of the brain injury or neural injury. Significant attempts have been made to develop effective therapies for TBI, and one of the most promising approaches is a stem cell based therapeutic approach with mesenchymal stem cells (MSCs). This approach is regarded as having the most potential in regenerative medicine. Toward this venture, the generation and release of exosomes can be attributed to the therapeutic effects of MSCs. Exosomes are nanosized vesicles, carry proteins, lipids, mRNA, and miRNA, and assist in cell-cell communication. Exosomes can interact with brain parenchyma cells and with the neurogenic niche, which can help in neurogenesis and brain remodeling. Exosomes derived from MSCs and human-induced pluripotent stem cells (hiPSCs) can be a promising approach in neuronal injury healing. In this Viewpoint, we discussed the most recent knowledge for exosome therapies for neural injuries and highlighted the major advantages of this therapy.
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Exosomes from hiPSCs and MSCs may heal neuronal damage caused by traumatic brain injury.
“For example, traumatic brain injury (TBI) can cause severe neuronal damage, and studies have shown that exosomes from human-induced pluripotent stem cells (hiPSCs) and MSCs may heal neuronal damage [68].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [68]
Cites
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Exosomes regulate neurogenesis and circuit assembly
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Emerging potential of exosomes for treatment of traumatic brain injury
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Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets
Thapa, K., Khan, H., Singh, T. G., & Kaur, A. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01841-7 · Cited by 341 · see citing works
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Clinical Theragnostic Signature of Extracellular Vesicles in Traumatic Brain Injury (TBI)
Dey, A., Ghosh, S., Bhuniya, T., Koley, M., Bera, A., Guha, S., Chakraborty, K., Muthu, S., Gorai, S., Vorn, R., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00386 · Cited by 16 · see citing works
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Self-citation
- Authors
- Ghosh, S., Garg, S., & Ghosh, S.
- Affiliations
- Indian Institute of Technology Jodhpur (IN)
- Corresponding author
- Ghosh, Surajit
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-07-01
- Volume
- 11
- Issue
- 14
- Pages
- 2045-2047
- ISSN
- 1948-7193 (ISSN-L)
- OpenAlex
- W3039144570
- Cited by
- 43
- References
- 5
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 11 · 2022: 14 · 2021: 5 · 2020: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Chemical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science and Engineering Research Board (CRG/2019/000670)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- exosomes, traumatic brain injury, mesenchymal stem cells, human induced pluripotent stem cells, nerve injury, neurogenesis, neurogenic niche, intercellular communication, exosome therapy, brain remodeling
- MeSH terms
- Brain Injuries, Traumatic, Humans, Regenerative Medicine, Exosomes, Neurogenesis, Mesenchymal Stem Cells
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