Cited by 58Traumatic Brain Injury and Neurovascular DisturbancesExtracellular vesicles in diseaseNerve injury and regeneration

Integrated printed BDNF-stimulated HUCMSCs-derived exosomes/collagen/chitosan biological scaffolds with 3D printing technology promoted the remodelling of neural networks after traumatic brain injury

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Liu, Xiaoyin, Zhang, Jian, Cheng, Xu, Liu, Peng, Feng, Qingbo, Wang, Shan, Li, Yuanyou, Gu, Haoran +3 more·2023·Regenerative Biomaterials

Abstract

Abstract The restoration of nerve dysfunction after traumatic brain injury (TBI) faces huge challenges due to the limited self-regenerative abilities of nerve tissues. In situ inductive recovery can be achieved utilizing biological scaffolds combined with endogenous human umbilical cord mesenchymal stem cells (HUCMSCs)-derived exosomes (MExos). In this study, brain-derived neurotrophic factor-stimulated HUCMSCs-derived exosomes (BMExos) were composited with collagen/chitosan by 3D printing technology. 3D-printed collagen/chitosan/BMExos (3D-CC-BMExos) scaffolds have excellent mechanical properties and biocompatibility. Subsequently, in vivo experiments showed that 3D-CC-BMExos therapy could improve the recovery of neuromotor function and cognitive function in a TBI model in rats. Consistent with the behavioural recovery, the results of histomorphological tests showed that 3D-CC-BMExos therapy could facilitate the remodelling of neural networks, such as improving the regeneration of nerve fibres, synaptic connections and myelin sheaths, in lesions after TBI.

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Crossref · 10.1093/rb/rbac085

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  • Exosomes from BDNF-stimulated HUCMSCs incorporated into collagen/chitosan scaffolds via 3D printing significantly improved neuromotor and cognitive abilities in a rat TBI model.

    “In a pioneering study by Liu et al., exosomes from BDNF-stimulated HUCMSCs (BMExos) were incorporated into collagen/chitosan scaffolds via 3D printing [290]. These scaffolds, which have outstanding mechanical properties and biocompatibility, were shown in vivo to significantly improve neuromotor and cognitive abilities in a rat TBI model”

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Authors
Liu, X., Zhang, J., Cheng, X., Liu, P., Feng, Q., Wang, S., Li, Y., Gu, H., Zhong, L., Chen, M., & Zhou, L.
Affiliations
  • Sichuan University (CN)
  • Chinese People's Armed Police Force (CN)
  • Chinese People's Liberation Army (CN)
  • First Affiliated Hospital of Chengdu Medical College (CN)
  • Xinjiang Medical University (CN)
Corresponding author
  • Zhong, Lin
  • Chen, Miao
  • Zhou, Liangxue
Venue
Regenerative Biomaterials
Published
2022-10-26
Volume
10
Pages
rbac085-rbac085
ISSN
  • 2056-3418 (ISSN-L)
  • 2056-3426
OpenAlex
W4307303101
Cited by
58
References
51
Citations by year
2026: 16 · 2025: 7 · 2024: 24 · 2023: 11
FWCI
5.53
Type
journal article
Language
en
Open access
Locations
  • Regenerative Biomaterials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Major Scientific and Technological Special Project for Significant New Drugs Development (2015ZX09102010)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
traumatic brain injury, exosomes, human umbilical cord mesenchymal stem cells, brain-derived neurotrophic factor, collagen, chitosan, 3D-printed scaffolds, cognitive recovery, myelin sheath regeneration, synaptic connectivity, in situ tissue engineering

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