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Neuroprotective Effects of σ 2 R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington’s Disease
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Preclinical studies support that S2R small molecule modulators can rescue biological processes that are impaired in neurodegenerative diseases.
“Preclinical studies support that S2R small molecule modulators can rescue biological processes that are impaired in neurodegenerative diseases [2,3,4,5].”
From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [5]
S2R, but not sigma-1 receptor modulators, reduce the neuronal toxicity induced by Htt-N586-82Q in primary cortical neuronal cultures.
“S2R, but not sigma-1 receptor modulators reduce the neuronal toxicity induced by Htt-N586-82Q in primary cortical neuronal cultures [5].”
From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [5]
S2R modulators have been shown to be neuroprotective in neuronal culture models of Huntington's disease.
“S2R modulators have also been shown to be neuroprotective in neuronal culture models of Huntington’s disease [5].”
From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [5]
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Automated design of ligands to polypharmacological profiles
Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X.-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., et al. (2012) · Nature · doi:10.1038/nature11691 · Cited by 832
Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening
Bartz, F., Kern, L., Erz, D., Zhu, M., Gilbert, D., Meinhof, T., Wirkner, U., Erfle, H., Muckenthaler, M., Pepperkok, R., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.05.009 · Cited by 198
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Riad, A., Zeng, C., Weng, C.-C., Winters, H., Xu, K., Makvandi, M., Metz, T., Carlin, S., & Mach, R. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-35430-3 · Cited by 147
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Sorted by citations
Lizama, B. N., Kahle, J., Catalano, S. M., Caggiano, A. O., Grundman, M., & Hamby, M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076251 · Cited by 54
Metadata
- Authors
- Jin, J., Arbez, N., Sahn, J. J., Lu, Y., Linkens, K. T., Hodges, T. R., Tang, A., Wiseman, R., Martin, S. F., & Ross, C. A.
- Affiliations
- Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States
- Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States
- ORCID
- Martin, Stephen F.
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-09-15
- Volume
- 13
- Issue
- 19
- Pages
- 2852-2862
- ISSN
- 1948-7193
- PMC
- PMC9547941
- Cited by
- 21
- References
- 5
- Language
- en
- Licence
- Funders
- National Institute of Neurological Disorders and Stroke (NS086452)
- Welch Foundation (F-0652)
- National Institute of Mental Health and Neurosciences (HHSN-271-2018-00023-C)
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