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High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model
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SFM-1500 and SAS-1121 reduced neurodegeneration in mutant C. elegans models to wild-type control levels.
“These S2R modulators reduced neurodegeneration in mutant C. elegans models to wild-type control levels [142].”
From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [142]
Neuroprotection was demonstrated with SFM-1500 and SAS-1121 in a C. elegans model of amyloid precursor protein-induced progressive neurodegeneration.
“Neuroprotection was demonstrated with two S2R-binding norbenzomorphan analogues (SFM-1500 and SAS-1121) in a C. elegans model of amyloid precursor protein-induced progressive neurodegeneration [142].”
From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [142]
Sigma-2 receptor ligands prevent neurodegeneration in a worm model expressing human amyloid precursor protein.
“Yi et al.and Mondal et al.similarly found that Sigma-2 receptor ligands prevent neurodegeneration in a worm model expressing human amyloid precursor protein [44, 77].”
From Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease (2024) · cites this paper as [44]
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Cited by
Sorted by citations
Lizama, B. N., Kahle, J., Catalano, S. M., Caggiano, A. O., Grundman, M., & Hamby, M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076251 · Cited by 54
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Colom-Cadena, M., Toombs, J., Simzer, E., Holt, K., McGeachan, R., Tulloch, J., Jackson, R. J., Catterson, J. H., Spires-Jones, M. P., Rose, J., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-023-02679-6 · Cited by 44
Metadata
- Authors
- Mondal, S., Hegarty, E., Sahn, J. J., Scott, L. L., Gökçe, S. K., Martin, C., Ghorashian, N., Satarasinghe, P. N., Iyer, S., Sae-Lee, W., Hodges, T. R., Pierce, J. T., Martin, S. F., & Ben-Yakar, A.
- ORCID
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-02-09
- Volume
- 9
- Issue
- 5
- Pages
- 1014-1026
- ISSN
- 1948-7193
- PMC
- PMC5955835
- Cited by
- 41
- References
- 10
- Language
- en
- Funders
- Welch Foundation (F-0652)
- National Institute of Neurological Disorders and Stroke (R21 NS058646, R21 NS067340)
- National Institute on Aging (R01 RF1AG057355, R01 AG041135)
- LuMind Research Down Syndrome Foundation
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