Cholesterol Biosynthesis and Uptake in Developing Neurons

Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

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Cholesterol metabolism in the brain

Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906

Cholesterol metabolism and homeostasis in the brain

Zhang, J., & Liu, Q. (2015) · Protein & Cell · doi:10.1007/s13238-014-0131-3 · Cited by 686

Biosynthesis of Cholesterol and Other Sterols

Nes, W. D. (2011) · Chemical Reviews · doi:10.1021/cr200021m · Cited by 659

A newly recognized syndromeof multiple congenital anomalies

Smith, D. W., Lemli, L., & Opitz, J. M. (1964) · The Journal of Pediatrics · doi:10.1016/s0022-3476(64)80264-x · Cited by 650

The Biological Synthesis of Cholesterol

Bloch, K. (1965) · Science · doi:10.1126/science.150.3692.19 · Cited by 562

The Indispensable Roles of Microglia and Astrocytes during Brain Development

Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00566 · Cited by 516

Malformation syndromes caused by disorders of cholesterol synthesis

Porter, F. D., & Herman, G. E. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009548 · Cited by 473

Mutations in the 3β-Hydroxysterol Δ24-Reductase Gene Cause Desmosterolosis, an Autosomal Recessive Disorder of Cholesterol Biosynthesis

Waterham, H. R., Koster, J., Romeijn, G. J., Hennekam, R. C. M., Vreken, P., Andersson, H. C., FitzPatrick, D. R., Kelley, R. I., & Wanders, R. J. A. (2001) · The American Journal of Human Genetics · doi:10.1086/323473 · Cited by 355

Lipid rafts, cholesterol, and the brain

Korade, Z., & Kenworthy, A. K. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.02.019 · Cited by 342

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

Feringa, F. M., & van der Kant, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.690372 · Cited by 226

Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases

Yang, D., Wang, X., Zhang, L., Fang, Y., Zheng, Q., Liu, X., Yu, W., Chen, S., Ying, J., & Hua, F. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00828-0 · Cited by 179

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

Li, X., Zhang, J., Li, D., He, C., He, K., Xue, T., Wan, L., Zhang, C., & Liu, Q. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.005 · Cited by 165

Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association

Goldstein, L. B., Toth, P. P., Dearborn, J. L., Giugliano, R. P., Hirsh, B. J., Peña, J. M., Selim, M. H., & Woo, D. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atv.0000000000000164 · Cited by 99

Impaired cholesterol metabolism, neurons, and neuropsychiatric disorders

Cheon, S. Y. (2023) · Experimental Neurobiology · doi:10.5607/en23010 · Cited by 67

Connecting the Dots Between Hypercholesterolemia and Alzheimer’s Disease: A Potential Mechanism Based on 27-Hydroxycholesterol

Wu, M., Zhai, Y., Liang, X., Chen, W., Lin, R., Ma, L., Huang, Y., Zhao, D., Liang, Y., Zhao, W., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.842814 · Cited by 59

Central nervous system cholesterol metabolism in health and disease

Ho, W. Y., Hartmann, H., & Ling, S. (2022) · IUBMB Life · doi:10.1002/iub.2662 · Cited by 58

Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease

Kulas, J. A., Weigel, T. K., & Ferris, H. A. (2020) · Drug Development Research · doi:10.1002/ddr.21643 · Cited by 57

MeCP2 Is an Epigenetic Factor That Links DNA Methylation with Brain Metabolism

Vuu, Y. M., Roberts, C.-T., & Rastegar, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044218 · Cited by 55

TrkB transmembrane domain: bridging structural understanding with therapeutic strategy

Enkavi, G., Girych, M., Moliner, R., Vattulainen, I., & Ċastrén, E. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.02.001 · Cited by 51

Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?

Hartmann, H., Ho, W. Y., Chang, J., & Ling, S. (2021) · FEBS Journal · doi:10.1111/febs.16175 · Cited by 45

Medication effects on developmental sterol biosynthesis

Korade, Ž., Heffer, M., & Mirnics, K. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01074-5 · Cited by 42

Brain cholesterol homeostasis and its association with neurodegenerative diseases

Gao, Y., Ye, S., Tang, Y., Tong, W., & Sun, S. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105635 · Cited by 38

Cholesterol in the CNS: functions, recycling and remyelination

Wuerch, E. C., & Yong, V. W. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03490-8 · Cited by 41

Cholesterol in Brain Development and Perinatal Brain Injury: More than a Building Block

Lu, F., Ferriero, D. M., & Jiang, X. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666211111122311 · Cited by 39

LXR agonism for CNS diseases: promises and challenges

Zhang, R., Wuerch, E. C., Yong, V. W., & Xue, M. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03056-0 · Cited by 40

Transcriptome analysis of human induced excitatory neurons supports a strong effect of clozapine on cholesterol biosynthesis

Das, D., Peng, X., Lam, A.-T. N., Bader, J. S., & Avramopoulos, D. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2020.12.041 · Cited by 17

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Madrer, N., Perera, N. D., Uccelli, N. A., Abbondanza, A., Andersen, J. V., Carsana, E. V., Demmings, M. D., Fernandez, R. F., de Fragas, M. G., Gbadamosi, I., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70084 · Cited by 37

Role of the endoplasmic reticulum in synaptic transmission

Chanaday, N. L., & Kavalali, E. T. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102538 · Cited by 34

Targeting of Mevalonate-Isoprenoid Pathway in Acute Myeloid Leukemia Cells by Bisphosphonate Drugs

Chiarella, E., Nisticò, C., Vito, A. D., Morrone, H. L., & Mesuraca, M. (2022) · Biomedicines · doi:10.3390/biomedicines10051146 · Cited by 35

Balancing cholesterol in the brain: from synthesis to disposal

Qian, L., Chai, A. B., Gelissen, I. C., & Brown, A. J. (2022) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2022.00015 · Cited by 31

Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis

Genaro‐Mattos, T. C., Anderson, A. C., Allen, L. B., Tallman, K. A., Porter, N. A., Korade, Ž., & Mirnics, K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0801-x · Cited by 31

Cholesterol Metabolism in Neurodegenerative Diseases

He, K., Zhao, Z., Zhang, J., Li, D., Wang, S., & Liu, Q. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0674 · Cited by 30

Pro-myelinating Clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health

Chen, K., Cambi, F., & Kozai, T. D. Y. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122210 · Cited by 27

Amiodarone Alters Cholesterol Biosynthesis through Tissue-Dependent Inhibition of Emopamil Binding Protein and Dehydrocholesterol Reductase 24

Allen, L. B., Genaro‐Mattos, T. C., Anderson, A. C., Porter, N. A., Mirnics, K., & Korade, Ž. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00042 · Cited by 28

Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism

Domingues, M. F., Callai-Silva, N., Piovesan, A. R., & Carlini, C. R. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00325 · Cited by 26

Inverted U-shaped correlation between serum low-density lipoprotein cholesterol levels and cognitive functions of patients with type 2 diabetes mellitus

Zhang, H., Zhu, W., Niu, T., Wang, Z., An, K., Cao, W., Shi, J., & Wang, S. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01534-5 · Cited by 26

The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

Vuu, Y. M., Shahib, A. K., & Rastegar, M. (2023) · Pharmaceuticals · doi:10.3390/ph16070914 · Cited by 33

Vitamin D, a Secosteroid Hormone and Its Multifunctional Receptor, Vitamin D Receptor, in Alzheimer’s Type Neurodegeneration

Gezen‐Ak, D., & Dursun, E. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230214 · Cited by 29

Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology

Lazar, A. N., Hanbouch, L., Boussicaut, L., Fourmaux, B., Daira, P., Millan, M. J., Bernoud‐Hubac, N., & Potier, M. (2022) · Cells · doi:10.3390/cells11223616 · Cited by 23

Cholesterol Metabolism in CNS Diseases: The Potential of SREBP2 and LXR as Therapeutic Targets

Wang, N.-Q., Sun, P.-X., Shen, Q.-Q., & Deng, M.-Y. (2025) · Molecular Neurobiology · doi:10.1007/s12035-024-04672-w · Cited by 19

How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)Preprint

Girych, M., Kulig, W., Enkavi, G., & Vattulainen, I. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041419 · Cited by 18

Sterol dysregulation in Smith–Lemli–Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk

Freel, B. A., Kelvington, B. A., Sengupta, S., Mukherjee, M., & Francis, K. R. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049843 · Cited by 17

Astrocyte‐specific loss of lactoferrin influences neuronal structure and function by interfering with cholesterol synthesis

Xu, S.-F., Pang, Z.-Q., Fan, Y.-G., Zhang, Y.-H., Meng, Y., Bai, C.-Y., Jia, M., Chen, Y.-H., Wang, Z.-Y., & Guo, C. (2022) · Glia · doi:10.1002/glia.24259 · Cited by 15

Cellular Lipidome Changes during Retinoic Acid (RA)-Induced Differentiation in SH-SY5Y Cells: A Comprehensive In Vitro Model for Assessing Neurotoxicity of Contaminants

Camdzic, M., Aga, D. S., & Atilla‐Gokcumen, G. E. (2023) · Environment & Health · doi:10.1021/envhealth.3c00022 · Cited by 16

Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma

Gunda, V., Genaro-Mattos, T. C., Kaushal, J., Chirravuri-Venkata, R., Natarajan, G., Mallya, K., Grandgenett, P. M., Mirnics, K., Batra, S. K., Korade, Ž., et al. (2022) · Metabolites · doi:10.3390/metabo12010047 · Cited by 17

Quantitative and carbon isotope ratio analysis of fatty acids isolated from human brain hemispheres

Lacombe, R. J. S., Smith, M. E., Perlman, K., Turecki, G., Mechawar, N., & Bazinet, R. P. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15702 · Cited by 19

Lovastatin Differentially Regulates α7 and α4 Neuronal Nicotinic Acetylcholine Receptor Levels in Rat Hippocampal Neurons

Borroni, V., Kamerbeek, C. B., Pediconi, M. F., & Barrantes, F. J. (2020) · Molecules · doi:10.3390/molecules25204838 · Cited by 15

Optimized culture of retinal ganglion cells and amacrine cells from adult mice

Park, Y. H., Snook, J. D., Zhuang, I., Shen, G., & Frankfort, B. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0242426 · Cited by 15

Prenylation Defects and Oxidative Stress Trigger the Main Consequences of Neuroinflammation Linked to Mevalonate Pathway Deregulation

Pisanti, S., Rimondi, E., Pozza, E., Melloni, E., Zauli, E., Bifulco, M., Martinelli, R., & Marcuzzi, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159061 · Cited by 16

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

Huang, R., Pang, Q., Zheng, L., Lin, J., Li, H., Wan, L., & Wang, T. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01462 · Cited by 19

Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

Balog, M., Anderson, A. C., Genaro‐Mattos, T. C., Korade, Ž., & Mirnics, K. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100249 · Cited by 14

Deep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus

Nguyen, T. A. T., Heng, J. W. J., Ng, Y. T., Sun, R., Fisher, S., Oguz, G., Kaewsapsak, P., Xue, S., Reversade, B., Ramasamy, A., et al. (2023) · BMC Biology · doi:10.1186/s12915-023-01756-2 · Cited by 12

Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Niemann-Pick Type C1

Völkner, C., Liedtke, M., Hermann, A., & Frech, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020710 · Cited by 14

Enhancing 7-dehydrocholesterol suppresses brain ferroptosis and tissue injury after neonatal hypoxia–ischemia

Genaro‐Mattos, T. C., Korade, Ž., Sahar, N.-E., Angeli, J. P. F., Mirnics, K., & Peeples, E. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-58579-6 · Cited by 13

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone

Cenik, B., Palka, J. M., Thompson, B. M., McDonald, J. G., Tamminga, C. A., Cenik, C., & Brown, E. S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01903-3 · Cited by 12

Effects of food-borne cholesterol supplementation on lead-induced neurodevelopmental impairments of rats based on BDNF signaling pathway and cholesterol metabolism

Wang, S., Lu, A.-X., Li, W.-H., Zhang, H., Hu, C., Liu, J., Pan, H., Wu, M., Xu, X., Yan, C., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115026 · Cited by 11

Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma

Masson, E., Serrano, J., Léger-Charnay, E., & Acar, N. (2024) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1303649 · Cited by 12

Astrocytic lactoferrin deficiency augments MPTP-induced dopaminergic neuron loss by disturbing glutamate/calcium and ER-mitochondria signaling

Xu, S., Cui, J.-H., Liu, X., Pang, Z., Bai, C., Jiang, C., Luan, C., Li, Y., Zhao, Y., You, Y., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.284 · Cited by 11

Role of cholesterol in modulating brain hyperexcitability

Wheless, J. W., & Rho, J. M. (2024) · Epilepsia · doi:10.1111/epi.18174 · Cited by 11

Lipolysis-Stimulated Lipoprotein Receptor Acts as Sensor to Regulate ApoE Release in Astrocytes

Herzine, A., Sekkat, G., Kaminski, S., Calcagno, G., Boschi‐Müller, S., Safi, H., Corbier, C., Visvikis‐Siest, S., Claudepierre, T., & Yen, F. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158630 · Cited by 11

Labelfree mapping and profiling of altered lipid homeostasis in the rat hippocampus after traumatic stress: Role of oxidative homeostasis

Kelley, D. P., Chaichi, A., Duplooy, A., Singh, D. P., Gartia, M. R., & Francis, J. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100476 · Cited by 11

The low-density lipoprotein receptor-related protein-1 (LRP1) in Schwann cells controls mitochondria homeostasis in peripheral nerves

Martellucci, S., Heredia, M., Wang, Z., Whisenant, T. C., Strickland, D. K., Sánchez, R. G., Arai, T., Zhang, M., Wang, H., Gong, Z., et al. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102796 · Cited by 10

Cholesterol metabolism and brain injury in neonatal encephalopathy

Dave, A. M., & Peeples, E. S. (2020) · Pediatric Research · doi:10.1038/s41390-020-01218-3 · Cited by 9

An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

Talvio, K., Wagner, V. A., Minkeviciene, R., Kirkwood, J. S., Kulinich, A. O., Umemori, J., Bhatia, A., Hur, M., Käkelä, R., Ethell, I. M., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05147-9 · Cited by 8

Spatially heterogeneous lipid dysregulation in tuberculous meningitis

Kim, J., Spears, I., Erice, C., Kim, H., Porter, N. A., Tressler, C. M., & Tucker, E. W. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106721 · Cited by 8

Metoprolol Inhibits Developmental Brain Sterol Biosynthesis in Mice

Allen, L. B., & Mirnics, K. (2022) · Biomolecules · doi:10.3390/biom12091211 · Cited by 8

TGF-β1 suppresses de novo cholesterol biosynthesis in granulosa-lutein cells by down-regulating DHCR24 expression via the GSK-3β/EZH2/H3K27me3 signaling pathway

Li, H., Shen, J., Ma, S., Zhao, F., Zhao, W., Chen, F., Fu, Y., Li, B., Cheng, J., & Deng, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.196 · Cited by 8

7-ketocholesterol as a critical oxysterol: Impact on human health and safety in food systems

Kumar, S. S., Prakash, A., Keerthana, P. V., & John, M. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106856 · Cited by 7

DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling

Li, H., Yang, Z. L., Liang, W., Nie, H., Guan, Y., Yang, N., Ji, T., Liu, Y., Huang, Y., Zhang, L., et al. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae059 · Cited by 7

Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma

Zhang, X., Gao, R., Yang, L., Zhu, Y., Zhang, T., Shen, X., Gu, W., Yang, L., & Peng, S. (2024) · Clinical and Translational Discovery · doi:10.1002/ctd2.287 · Cited by 8

Divergent organ-specific isogenic metastatic cell lines identified using multi-omics exhibit differential drug sensitivity

Winnard, P. T., Vesuna, F., Muthukumar, S., & Raman, V. (2020) · PLoS ONE · doi:10.1371/journal.pone.0242384 · Cited by 8

Epoxiconazole altered hepatic metabolism in adult zebrafish based on transcriptomic analysis

Weng, Y. Z., Gu, W., & Jin, Y. (2024) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2024.109901 · Cited by 6

Astrocyte-Neuron Metabolic Synergies in Neurological Homeostasis and Disease

Dong, J., Gao, Z., Liu, M., Qian, B., Yuan, C., Liu, H., Rao, N., & Liu, Y. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04548-y · Cited by 5

PCSK9 Regulation of Lipid Metabolism in the Nervous System: Implications for Schwann Cell Function and Peripheral Neuropathy

Nowacka, A., Śniegocki, M., & Ziółkowska, E. (2025) · Cells · doi:10.3390/cells14181479 · Cited by 5

Regulation of sterol metabolism by gut microbiota and its relevance to disease

Huang, C., Wu, Q., Wang, J., Cai, J., Wang, Z., You, L., Zhu, Z., & Ding, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2589493 · Cited by 5

Sex Differences in the Association Between LDL/HDL with Cognitive Decline in Older Adults: National Health and Nutrition Examination Survey

Wen, J., Hao, X., Jia, Y., Wang, B., Pang, J., & Liang, F. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231195 · Cited by 6

Therapeutic Potential of Simvastatin: Cellular Mechanism, Binding Energetics, and Resistance Developments

Verma, S., Malviya, R., Sundaram, S., Srivastava, S., Sridhar, S. B., Rab, S. O., & Singh, D. P. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266327892241223052456 · Cited by 4

Fundamental origins of neural tube defects with a basis in genetics and nutrition

Bhasker, A., & Veleri, S. (2025) · Experimental Brain Research · doi:10.1007/s00221-025-07016-9 · Cited by 4

Exploring Recent Developments in the Manifestation, Diagnosis, and Treatment of Patients with Smith–Lemli–Opitz Syndrome: From Molecular Pathways to Clinical Innovations

Żukowska, A., Król, M., Kupnicka, P., Bąk, K., Janawa, K., & Chlubek, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146672 · Cited by 4

Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neuronal membranes

Zubillaga, M., Tau, J., Rosa, D. E., Bellini, M. J., & Arnal, N. (2024) · Biology of Sex Differences · doi:10.1186/s13293-023-00578-9 · Cited by 4

Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer’s Disease

Staurenghi, E., Testa, G., Leoni, V., Cecci, R., Floro, L., Giannelli, S., Barone, E., Marzia Perluigi, A., Leonarduzzi, G., Sottero, B., et al. (2024) · Antioxidants · doi:10.3390/antiox13040435 · Cited by 4

Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis

Chen, P., Li, J., Telezhkin, V., Gu, Y., Tao, M., Guo, L., Song, S., Dong, R., Luo, X., Wang, Y., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04469-1 · Cited by 3

Compromised lipid metabolism, mitochondria respiration and neuroprotective effects in iPSC-derived astrocytes from a Smith-Lemli-Opitz syndrome patient

Kawatani, K., Baker, S. K., Yaeger, J. D. W., Anderson, R. H., Ren, Y., Li, Z., Bao, H., Han, X., Francis, K. R., & Kanekiyo, T. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddaf159 · Cited by 3

Special characteristics of human astrocytes and their roles in brain homeostasis

Kousa, I., Talvio, K., Peteri, U., & Castrén, M. L. (2026) · Neuroscience Applied · doi:10.1016/j.nsa.2026.107000 · Cited by 3

Split GFP-based fluorescent biosensors detect ER–Golgi membrane contact dynamics

Mao, R., Zhai, J., Tong, C., Fu, W., Li, D., & Liu, J. (2026) · Journal of Cell Science · doi:10.1242/jcs.264795 · Cited by 3

Hydroxyzine Effects on Post-Lanosterol Biosynthesis in Smith–Lemli–Opitz Syndrome (SLOS) Models

Korade, Ž., Anderson, A. C., Balog, M., Tallman, K. A., Porter, N. A., & Mirnics, K. (2025) · Biomolecules · doi:10.3390/biom15040562 · Cited by 3

Proteomic analysis discovers potential biomarkers of early traumatic axonal injury in the brainstem

Chen, Q., Li, L., Xu, L., Yang, B., Huang, Y., Qiao, D., & Yue, X. (2023) · International Journal of Legal Medicine · doi:10.1007/s00414-023-03039-5 · Cited by 3

Regulation of CNS Lipids by Protease Activated Receptor 1

Yoon, H., Triplet, E. M., Wurtz, L. I., Simon, W. L., Choi, C., & Scarisbrick, I. A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70047 · Cited by 2

Fetal Fentanyl Syndrome – Only the “tip of the iceberg”?

Mirnics, K. (2024) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2024.10.011 · Cited by 2

Identification of novel nutrient sensitive human yolk sac functions required for embryogenesis

White, M., Arif‐Pardy, J., Bloise, E., & Connor, K. L. (2024) · Scientific Reports · doi:10.1038/s41598-024-81061-2 · Cited by 2

Cardiovascular disease and its association with insulin resistance and cholesterol

Ali, N. M., Diamond, D. M., & Rice, S. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821617-0.00016-4 · Cited by 2

Astrocyte, Lipid Metabolism in Alzheimer’s Disease and Glioblastoma

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Global cell-state and gene-program representations reveal conserved and context-specific perturbation responses of cellsPreprint

Pan, X., Saunders, R. A., Replogle, J. M., Weissman, J. S., & Zhuang, X. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.16.725005 · Cited by 3

Identifying biomarkers of hepatic fatty acid metabolism disorder in sevoflurane-induced brain developmental injury by bioinformatics analysis

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