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Cited by 165

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Shape Effect of Glyco-Nanoparticles on Macrophage Cellular Uptake and Immune Response

Open access
Li, Zhen, Sun, Liang, Zhang, Yufei, Dove, Andrew P., O’Reilly, Rachel K., Chen, Guosong·2016·ACS Macro Letters

Abstract

Abstract The shells of various poly(dl-lactide)-b-poly(acrylic acid) (PDLLA-b-PAA) spherical micelles and poly(l-lactide)-b-poly(acrylic acid) (PLLA-b-PAA) cylindrical micelles were functionalized with mannose to yield glyco-nanoparticles (GNPs) with different shapes and dimensions. All of these GNPs were shown to have good biocompatibility (up to 1 mg/mL). Cellular uptake experiments using RAW 264.7 have shown that the spherical GNPs were internalized to a much greater extent than the cylindrical GNPs and such a phenomenon was attributed to their different endocytosis pathways. It was demonstrated that spherical GNPs were internalized based on clathrin- and caveolin-mediated endocytosis while cylindrical GNPs mainly depended on clathrin-mediated endocytosis. We also found that longer cylindrical GNPs (Ln × Wn = 215 × 47 nm) can induce an inflammatory response (specifically interleukin 6) more efficiently than shorter cylindrical GNPs (Ln × Wn = 99 × 50 nm) and spherical GNPs (Dn = 46 nm).

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Metadata

Authors
Li, Z., Sun, L., Zhang, Y., Dove, A. P., O’Reilly, R. K., & Chen, G.
Venue
ACS Macro Letters
Published
2016-09-11
Volume
5
Issue
9
Pages
1059-1064
ISSN
2161-1653 (ISSN-L)
OpenAlex
W2516726340
Cited by
165
References
4
FWCI
3.63
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Shape Effect of Glyco-Nanoparticles on Macrophage Cellular Uptake and Immune Response. https://app.cochat.ai/papers/10.1021/acsmacrolett.6b00419
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Li, Z., Sun, L., Zhang, Y., Dove, A. P., O’Reilly, R. K., & Chen, G. (2016). Shape Effect of Glyco-Nanoparticles on Macrophage Cellular Uptake and Immune Response. ACS Macro Letters. https://doi.org/10.1021/acsmacrolett.6b00419

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