Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood–Brain Barrier

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works

Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells

Chithrani, D. B., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,887 · see citing works

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.012 · Cited by 4,523 · see citing works

Elucidating the Mechanism of Cellular Uptake and Removal of Protein-Coated Gold Nanoparticles of Different Sizes and Shapes

Chithrani, D. B., & Chan, W. C. W. (2007) · Nano Letters · doi:10.1021/nl070363y · Cited by 2,274 · see citing works

Blood-brain barrier breakdown in the aging human hippocampus

Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102 · see citing works

Nanoparticle PEGylation for Imaging and Therapy

Jokerst, J. V., Lobovkina, T., Zare, R. N., & Gambhir, S. S. (2011) · Nanomedicine · doi:10.2217/nnm.11.19 · Cited by 2,054 · see citing works

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D’Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0297-y · Cited by 1,728 · see citing works

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

Hartsock, A., & Nelson, W. J. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.012 · Cited by 1,559 · see citing works

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing

Cabeza, R., Albert, M., Belleville, S., Craik, F. I. M., Duarte, A., Grady, C. L., Lindenberger, U., Nyberg, L., Park, D. C., Reuter-Lorenz, P. A., et al. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0068-2 · Cited by 1,289 · see citing works

Tumor targeting via EPR: Strategies to enhance patient responses

Golombek, S. K., May, J.-N., Theek, B., Appold, L., Drude, N., Kiessling, F., & Lammers, T. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.007 · Cited by 1,262 · see citing works

The far-reaching scope of neuroinflammation after traumatic brain injury

Simon, D. W., McGeachy, M. J., Bayır, H., Clark, R. S. B., Loane, D. J., & Kochanek, P. M. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.13 · Cited by 1,190 · see citing works

Tight junctions of the blood-brain barrier: development, composition and regulation.

Wolburg, H., & Lippoldt, A. (2002) · PubMed · doi:10.1016/s1537-1891(02)00200-8 · Cited by 1,184 · see citing works

Ageing, neurodegeneration and brain rejuvenation

Wyss-Coray, T. (2016) · Nature · doi:10.1038/nature20411 · Cited by 1,147 · see citing works

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat

Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060 · see citing works

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

Farrall, A. J., & Wardlaw, J. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.015 · Cited by 882 · see citing works

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Zhang, G., Li, J., Purkayastha, S., Tang, Y., Zhang, H., Yin, Y., Li, B., Liu, G., & Cai, D. (2013) · Nature · doi:10.1038/nature12143 · Cited by 834 · see citing works

Wnt/β-catenin signaling controls development of the blood–brain barrier

Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C. J., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806024 · Cited by 793 · see citing works

Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands

Furuse, M., Sasaki, H., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.4.891 · Cited by 746 · see citing works

Rapid combined T1 and T2 mapping using gradient recalled acquisition in the steady state

Deoni, S., Rutt, B. K., & Peters, T. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10407 · Cited by 745 · see citing works

The mitochondrial‐lysosomal axis theory of aging

Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729 · see citing works

Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708 · see citing works

Poly(ethylene glycol)-modified Nanocarriers for Tumor-targeted and Intracellular Delivery

van Vlerken, L. E., Vyas, T. K., & Amiji, M. M. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9284-6 · Cited by 646 · see citing works

Blood brain barrier: ageing and microvascular disease-systematic review and meta-analysis

Farrall, A., & Wardlaw, J. M. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.089 · Cited by 639 · see citing works

Polymeric nanoparticles for drug delivery to the central nervous system

Patel, T., Zhou, J., Piepmeier, J. M., & Saltzman, W. M. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.006 · Cited by 569 · see citing works

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Minhas, P. S., Latif-Hernandez, A., McReynolds, M. R., Durairaj, A. S., Wang, Q., Rubin, A., Joshi, A. U., He, J. Q., Gauba, E., Liu, L., et al. (2021) · Nature · doi:10.1038/s41586-020-03160-0 · Cited by 526 · see citing works

Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds

Kwon, G. S. (2003) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v20.i5.20 · Cited by 502 · see citing works

Microvascular injury and blood–brain barrier leakage in Alzheimer's disease

Zipser, B. D., Johanson, C. E., Gonzalez, L., Berzin, T. M., Tavares, R., Hulette, C. M., Vitek, M. P., Hovanesian, V., & Stopa, E. G. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.016 · Cited by 487 · see citing works

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

Hasegawa, K., Wakino, S., Šimić, P., Sakamaki, Y., Minakuchi, H., Fujimura, K., Hosoya, K., Komatsu, M., Kaneko, Y., Kanda, T., et al. (2013) · Nature Medicine · doi:10.1038/nm.3363 · Cited by 485 · see citing works

High‐resolution T1 and T2 mapping of the brain in a clinically acceptable time with DESPOT1 and DESPOT2

Deoni, S., Peters, T. M., & Rutt, B. K. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20314 · Cited by 482 · see citing works

Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain

Liang, W. S., Dunckley, T. L., Beach, T. G., Grover, A., Mastroeni, D., Walker, D. G., Caselli, R. J., Kukull, W. A., McKeel, D. W., Morris, J. C., et al. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00208.2006 · Cited by 342 · see citing works

Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain

Mullier, A., Bouret, S. G., Prevot, V., & Dehouck, B. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22273 · Cited by 334 · see citing works

Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport.

Kumagai, A. K., Eisenberg, J., & Pardridge, W. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48160-4 · Cited by 325 · see citing works

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

Elahy, M., Jackaman, C., Mamo, J. C., Lam, V., Dhaliwal, S. S., Giles, C., Nelson, D., & Takechi, R. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0029-9 · Cited by 300 · see citing works

Neutrophil Accumulation After Traumatic Brain Injury in Rats: Comparison of Weight Drop and Controlled Cortical Impact Models

Clark, R. S. B., Schiding, J. K., Kaczorowski, S. L., Marion, D. W., & Kochanek, P. M. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.499 · Cited by 291 · see citing works

Thioalkylated tetraethylene glycol: a new ligand for water soluble monolayer protected gold clusters

Kanaras, A. G., Kamounah, F. S., Schaumburg, K., Kiely, C. J., & Brust, M. (2002) · Chemical Communications · doi:10.1039/b207838b · Cited by 256 · see citing works

Synthesis and characterisation of Gd2O3 nanocrystals functionalised by organic acids

Söderlind, F., Pedersen, H., Petoral, R. M., Käll, P., & Uvdal, K. (2005) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2005.02.089 · Cited by 251 · see citing works

Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

Feng, S., Cen, J., Huang, Y., Shen, H., Li, Y., Wang, Y., & Chen, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020599 · Cited by 236 · see citing works

Infrared spectra of oxalate, malonate and succinate adsorbed on the aqueous surface of rutile, anatase and lepidocrocite measured with in situ ATR-FTIR

Hug, S. J., & Bahnemann, D. W. (2005) · Journal of Electron Spectroscopy and Related Phenomena · doi:10.1016/j.elspec.2005.05.006 · Cited by 231 · see citing works

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

Horng, S., Therattil, A., Moyon, S., Gordon, A., Kim, K., Argaw, A. T., Hara, Y., Mariani, J. N., Sawai, S., Flodby, P., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci91301 · Cited by 221 · see citing works

Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System Homeostasis

Tran, K. A., Zhang, X., Predescu, D., Huang, X., Machado, R. F., Göthert, J. R., Malik, A. B., Valyi-Nagy, T., & Zhao, Y.-Y. (2016) · Circulation · doi:10.1161/circulationaha.115.015982 · Cited by 219 · see citing works

Surface Characteristics of Nanoparticles Determine Their Intracellular Fate in and Processing by Human Blood–Brain Barrier Endothelial Cells In Vitro

Georgieva, J. V., Kalicharan, D., Couraud, P., Romero, I. A., Weksler, B. B., Hoekstra, D., & Zuhorn, I. S. (2010) · Molecular Therapy · doi:10.1038/mt.2010.236 · Cited by 211 · see citing works

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

Erickson, M. A., & Banks, W. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071632 · Cited by 192 · see citing works

Tracer kinetic modelling for DCE-MRI quantification of subtle blood–brain barrier permeability

Heye, A. K., Thrippleton, M. J., Armitage, P. A., Valdés Hernández, M. D. C., Makin, S. D., Glatz, A., Sakka, E., & Wardlaw, J. M. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.018 · Cited by 187 · see citing works

Structural organization of the tight junctions

Paris, L., Tonutti, L., Vannini, C., & Bazzoni, G. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.004 · Cited by 171 · see citing works

Shape Effect of Glyco-Nanoparticles on Macrophage Cellular Uptake and Immune Response

Li, Z., Sun, L., Zhang, Y., Dove, A. P., O’Reilly, R. K., & Chen, G. (2016) · ACS Macro Letters · doi:10.1021/acsmacrolett.6b00419 · Cited by 165 · see citing works

Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

Pfeiffer, F., Schäfer, J., Lyck, R., Makrides, V., Brunner, S., Schaeren-Wiemers, N., Deutsch, U., & Engelhardt, B. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0883-2 · Cited by 160 · see citing works

Claudin Heterogeneity and Control of Lung Tight Junctions

Koval, M. H. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183809 · Cited by 155 · see citing works

Claudins and the Kidney

Yu, A. S. L. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014030284 · Cited by 151 · see citing works

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

Stamatovic, S. M., Martínez-Revollar, G., Hu, A., Choi, J. H. K., Keep, R. F., & Andjelkovic, A. V. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.006 · Cited by 149 · see citing works

Immunolocalization of tight junction proteins in the adult and developing human brain

Virgintino, D., Errede, M., Robertson, D. M., Capobianco, C., Girolamo, F., Vimercati, A., Bertossi, M., & Roncali, L. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0665-1 · Cited by 145 · see citing works

Claudin-1-Dependent Destabilization of the Blood–Brain Barrier in Chronic Stroke

Sladojević, N., Stamatovic, S. M., Johnson, A., Choi, J. H. K., Hu, A., Dithmer, S., Blasig, I. E., Keep, R. F., & Andjelkovic, A. V. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1432-18.2018 · Cited by 142 · see citing works

Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide

Wu, L., Ahmadvand, D., Su, J., Hall, A., Tan, X., Farhangrazi, Z. S., & Moghimi, S. M. (2019) · Nature Communications · doi:10.1038/s41467-019-12554-2 · Cited by 140 · see citing works

Pericapillary Haem-Rich Deposits: Evidence for Microhaemorrhages in Aging Human Cerebral Cortex

Cullen, K. M., Kócsi, Z., & Stone, J. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600155 · Cited by 137 · see citing works

Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries

Kwon, E. J., Skalak, M., Bu, R. L., & Bhatia, S. N. (2016) · ACS Nano · doi:10.1021/acsnano.6b03858 · Cited by 134 · see citing works

Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia

Chen, T., Dai, S., Li, X., Luo, P., Zhu, J., Wang, Y., Fei, Z., & Jiang, X. (2017) · Redox Biology · doi:10.1016/j.redox.2017.09.016 · Cited by 134 · see citing works

Targeting nanoparticles to the brain by exploiting the blood–brain barrier impermeability to selectively label the brain endothelium

Gonzalez-Carter, D., Liu, X., Tockary, T. A., Dirisala, A., Toh, K., Anraku, Y., & Kataoka, K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002016117 · Cited by 127 · see citing works

A Key Claudin Extracellular Loop Domain is Critical for Epithelial Barrier Integrity

Mrsny, R. J., Brown, G. T., Gerner-Smidt, K., Buret, A. G., Meddings, J. B., Quan, C. L., Koval, M. H., & Nusrat, A. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070698 · Cited by 124 · see citing works

A 22-Amino Acid Synthetic Peptide Corresponding to the Second Extracellular Loop of Rat Occludin Perturbs the Blood-Testis Barrier and Disrupts Spermatogenesis Reversibly In Vivo1

Chung, N. P. Y., Mruk, D. D., Mo, M., Lee, W. M., & Cheng, C. Y. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.5.1340 · Cited by 121 · see citing works

Optimal acquisition and modeling parameters for accurate assessment of low K_trans blood-brain barrier permeability using dynamic contrast-enhanced MRI: Optimal Parameters for Accurate Low Permeability DCE-MRI Estimation

Barnes, S. R., Ng, T. S. C., Montagne, A., Law, M., Zlokovic, B. V., & Jacobs, R. E. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25793 · Cited by 115 · see citing works

Apo E-Functionalization of Solid Lipid Nanoparticles Enhances Brain Drug Delivery: Uptake Mechanism and Transport Pathways

Neves, A. R., Queiroz, J. F., Lima, S. A. C., & Reis, S. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00705 · Cited by 113 · see citing works

Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis

Uchida, Y., Sumiya, T., Tachikawa, M., Yamakawa, T., Murata, S., Yagi, Y., Sato, K., Stephan, A., Ito, K., Ohtsuki, S., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1207-5 · Cited by 97 · see citing works

Core-Cross-Linked Nanoparticles Reduce Neuroinflammation and Improve Outcome in a Mouse Model of Traumatic Brain Injury

Yoo, D., Magsam, A. W., Kelly, A. M., Stayton, P., Kievit, F., & Convertine, A. J. (2017) · ACS Nano · doi:10.1021/acsnano.7b03426 · Cited by 94 · see citing works

Temporal assessment of nanoparticle accumulation after experimental brain injury: Effect of particle size

Bharadwaj, V. N., Lifshitz, J., Adelson, P. D., Kodibagkar, V. D., & Stabenfeldt, S. E. (2016) · Scientific Reports · doi:10.1038/srep29988 · Cited by 93 · see citing works

Effects of particle size and ligand density on the kinetics of receptor-mediated endocytosis of nanoparticles

Yuan, H., & Zhang, S. (2010) · Applied Physics Letters · doi:10.1063/1.3293303 · Cited by 90 · see citing works

Who watches the watchmen? Regulation of the expression and activity of sirtuins

Buler, M., Andersson, U., & Hakkola, J. (2016) · The FASEB Journal · doi:10.1096/fj.201600410rr · Cited by 84 · see citing works

The blood-brain barrier choline transporter as a brain drug delivery vector

Allen, D. D., & Lockman, P. R. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00504-6 · Cited by 83 · see citing works

Postacute ischemia vascular endothelial growth factor transfer by transferrin-targeted liposomes attenuates ischemic brain injury after experimental stroke in rats.

Zhao, H., Bao, X.-J., Wang, R.-Z., Li, G.-L., Gao, J., Ma, S.-H., Wei, J.-J., Feng, M., Zhao, Y.-J., Ma, W.-B., et al. (2011) · Human Gene Therapy · doi:10.1089/hum.2010.111 · Cited by 73 · see citing works

Traumatic brain injury opens blood–brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect

Boyd, B. J., Galle, A., Daglas, M., Rosenfeld, J. V., & Medcalf, R. L. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1034280 · Cited by 71 · see citing works

Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers

Staat, C., Coisne, C., Dabrowski, S., Stamatovic, S. M., Andjelkovic, A. V., Wolburg, H., Engelhardt, B., & Blasig, I. E. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.007 · Cited by 66 · see citing works

Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase

Hattori, Y., Okamoto, Y., Maki, T., Yamamoto, Y., Oishi, N., Yamahara, K., Nagatsuka, K., Takahashi, R., Kalaria, R. N., Fukuyama, H., et al. (2014) · Stroke · doi:10.1161/strokeaha.114.006265 · Cited by 63 · see citing works

Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown

Vecchio, A. J., & Stroud, R. M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908929116 · Cited by 63 · see citing works

Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1)

Mooradian, A. D. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00041-6 · Cited by 57 · see citing works

Theranostic Oxygen Reactive Polymers for Treatment of Traumatic Brain Injury

Xu, J. M., Ypma, M., Chiarelli, P. A., Park, J. C., Ellenbogen, R. G., Stayton, P. S., Mourad, P. D., Lee, D., Convertine, A. J., & Kievit, F. M. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504416 · Cited by 54 · see citing works

Sex-Dependent Macromolecule and Nanoparticle Delivery in Experimental Brain Injury

Bharadwaj, V. N., Copeland, C., Mathew, E., Newbern, J. M., Anderson, T. R., Lifshitz, J., Kodibagkar, V. D., & Stabenfeldt, S. E. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0040 · Cited by 50 · see citing works

Age-Related Changes of Claudin Expression in Mouse Liver, Kidney, and Pancreas

D’Souza, T., Sherman‐Baust, C. A., Poosala, S., Mullin, J. M., & Morin, P. J. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp118 · Cited by 48 · see citing works

A Role for Nanoparticles in Treating Traumatic Brain Injury

Bony, B. A., & Kievit, F. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090473 · Cited by 43 · see citing works

Claudins are essential for cell shape changes and convergent extension movements during neural tube closure

Baumholtz, A. I., Simard, A., Nikolopoulou, E., Oosenbrug, M., Collins, M. M., Piontek, A., Krause, G., Piontek, J., Greene, N. D. E., & Ryan, A. K. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.05.013 · Cited by 34 · see citing works

Blood–brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury

Bharadwaj, V. N., Rowe, R. K., Harrison, J., Wu, C., Anderson, T. R., Lifshitz, J., Adelson, P., Kodibagkar, V., & Stabenfeldt, S. (2018) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2018.06.004 · Cited by 34 · see citing works

Ultrasmall Mixed Eu–Gd Oxide Nanoparticles for Multimodal Fluorescence and Magnetic Resonance Imaging of Passive Accumulation and Retention in TBI

Bony, B. A., Miller, H. A., Tarudji, A. W., Gee, C. C., Sarella, A., Nichols, M. G., & Kievit, F. M. (2020) · ACS Omega · doi:10.1021/acsomega.0c01890 · Cited by 30 · see citing works

Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via Ktrans mapping with MRI

Miller, H. A., Magsam, A. W., Tarudji, A. W., Romanova, S., Weber, L., Gee, C. C., Madsen, G. L., Bronich, T. K., & Kievit, F. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-52622-7 · Cited by 29 · see citing works

An Activity-Based Nanosensor for Traumatic Brain Injury

Kudryashev, J. A., Waggoner, L. E., Leng, H. T., Mininni, N. H., & Kwon, E. J. (2020) · ACS Sensors · doi:10.1021/acssensors.9b01812 · Cited by 28 · see citing works

Neuroimaging of cerebrovascular disease in the aging brain.

Gupta, A. K., Nair, S., Schweitzer, A. D., et al. (2012) · PubMed · Cited by 26 · see citing works

Gene delivery to brain cells with apoprotein E derived peptide conjugated to polylysine (apoEdp-PLL)

Mousazadeh, M. H., Palizban, A., Salehi, R., & Salehi, M. (2007) · Journal of drug targeting · doi:10.1080/10611860601148908 · Cited by 23 · see citing works

Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments

Andjelkovic, A. V., Situ, M., Citalán‐Madrid, A. F., Stamatovic, S. M., Xiang, J., & Keep, R. F. (2023) · Stroke · doi:10.1161/strokeaha.122.040578 · Cited by 175 · see citing works

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works

Blood–Brain Barrier-Targeting Nanoparticles: Biomaterial Properties and Biomedical Applications in Translational Neuroscience

Asimakidou, E., Tan, J. K. S., Zeng, J., & Lo, C. H. (2024) · Pharmaceuticals · doi:10.3390/ph17050612 · Cited by 115 · see citing works

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Wu, J., Zhu, Z., Liu, W., Zhang, Y., Kang, Y., Liu, J., Hu, C., Wang, R., Zhang, M., Chen, L., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c05317 · Cited by 109 · see citing works

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Lahooti, B., Akwii, R. G., Zahra, F. T., Sajib, M. S., Λάμπρου, Μ., Alobaida, A., Lionakis, M. S., Mattheolabakis, G., & Mikelis, C. M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.07.039 · Cited by 106 · see citing works

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Wu, J. R., Hernández, Y. M., Miyasaki, K. F., & Kwon, E. J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114820 · Cited by 103 · see citing works

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Che, J., Sun, Y., Deng, Y., & Zhang, J. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00563-3 · Cited by 103 · see citing works

The blood–brain barrier: a help and a hindrance

Rust, R., Yin, H. R., Buil, B. A., Sagare, A. P., & Kisler, K. (2025) · Brain · doi:10.1093/brain/awaf068 · Cited by 102 · see citing works

Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics

Markowicz-Piasecka, M., Markiewicz, A., Darłak, P., Sikora, J., Adla, S. K., Bagina, S., & Huttunen, K. M. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01228-5 · Cited by 68 · see citing works

Interfacing with the Brain: How Nanotechnology Can Contribute

Ahmed, A. A. A., Alegret, N., Almeida, B., Álvarez‐Puebla, R. A., Andrews, A. M., Ballerini, L., Barrios‐Capuchino, J. J., Becker, C., Blick, R. H., Bonakdar, S., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c10525 · Cited by 68 · see citing works

Precision targeting of the CNS: recent progress in brain-directed nanodrug delivery

Senanayake, D., Yapa, P. N., Dabare, S., & Munaweera, I. (2025) · RSC Advances · doi:10.1039/d5ra03578c · Cited by 52 · see citing works

Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery

Ramirez-Velez, I., & Belardi, B. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114905 · Cited by 45 · see citing works

Clinical translation of nanomedicines for brain diseases: Current challenges and future directions

Wang, G., Wang, N., Xia, X., Ismail, M., & Shi, B. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114426 · Cited by 33 · see citing works

Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury

Tarudji, A. W., Miller, H. A., Curtis, E. T., Porter, C. L., Madsen, G. L., & Kievit, F. M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.065 · Cited by 28 · see citing works

Advanced nanoparticle engineering for precision therapeutics of brain diseases

Ismail, M., Liu, J., Wang, N., Zhang, D., Qin, C., Shi, B., & Zheng, M. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123138 · Cited by 23 · see citing works

Blood-brain barrier biomarkers

Zapata-Acevedo, J. F., Mantilla-Galindo, A., Vargas-Sánchez, K., & González-Reyes, R. E. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.04.004 · Cited by 23 · see citing works

Claudin-1 impairs blood–brain barrier by downregulating endothelial junctional proteins in traumatic brain injury

Gowrikumar, S., Tarudji, A. W., McDonald, B. Z., Balusa, S. S., Kievit, F. M., & Dhawan, P. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2470482 · Cited by 21 · see citing works

Teriflunomide Promotes Blood–Brain Barrier Integrity by Upregulating Claudin-1 via the Wnt/β-catenin Signaling Pathway in Multiple Sclerosis

Zhao, Y., Chen, C., Xiao, X., Fang, L., Cheng, X., Chang, Y., Peng, F., Wang, J., Shen, S., Wu, S., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03655-7 · Cited by 20 · see citing works

Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier

Alonso-Alonso, M. L., Sampedro‐Viana, A., Fernández‐Rodicio, S., Bazarra‐Barreiros, M., Ouro, A., Sobrino, T., Campos, F., Castillo, J., Hervella, P., & Iglesias‐Rey, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169486 · Cited by 14 · see citing works

Functional Peptide-Based Biomaterials for Pharmaceutical Application: Sequences, Mechanisms, and Optimization Strategies

Yu, D., Han, N., Son, H., Kim, S. J., & Kweon, S. (2026) · Journal of Functional Biomaterials · doi:10.3390/jfb17010037 · Cited by 13 · see citing works

Nano-oncology revisited: Insights on precise therapeutic advances and challenges in tumor

Teng, L., Bi, Y., Xing, X., & Yao, G. (2025) · Fundamental Research · doi:10.1016/j.fmre.2025.03.024 · Cited by 13 · see citing works

Intratumoral Bacterial-Targeted Cascade-Responsive Sonoafterglow Nanoprobes for Immune Reprogramming and Visualization in Glioblastoma

Jiang, Y., Zhang, J., Ye, J., Jin, X., Zhao, Y., Xu, H., Chu, B., He, Y., & Wang, H. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c01626 · Cited by 12 · see citing works

Pericyte-glial cell interactions: Insights into brain health and disease

Sepehrinezhad, A., & Gorji, A. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01472 · Cited by 11 · see citing works

Glioblastoma induced blood-brain barrier dysfunction via a paracrine mechanism that increases claudin-1 expression

Schweiger, B., & Kievit, F. M. (2025) · Experimental Brain Research · doi:10.1007/s00221-025-07018-7 · Cited by 8 · see citing works

Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways

Wang, D., Wang, J., Li, B., Yang, S., Guo, F., Zheng, B., & Wang, J. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01312-4 · Cited by 9 · see citing works

Antioxidant Theranostic Copolymer‐Mediated Reduction in Oxidative Stress Following Traumatic Brain Injury Improves Outcome in a Mouse Model

Tarudji, A. W., Gee, C. C., Miller, H. A., Steffen, R., Curtis, E. T., Priester, A. M., Convertine, A. J., & Kievit, F. M. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300147 · Cited by 8 · see citing works

Polyphenolic oligomer-derived multienzyme activity for the treatment of ischemic Stroke through ROS scavenging and blood–brain barrier restoration

Meng, W., Ma, Z., Ye, H., Liu, L., Han, Q., & Shi, Q. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02676k · Cited by 5 · see citing works

Research progress on the role of Claudin family proteins in mediating blood-brain barrier selective permeability in tumor metastasis

Wei, D. (2025) · American Journal of Translational Research · doi:10.62347/gggx3909 · Cited by 3 · see citing works

A review on brain-targeting nano-based drug delivery

Li, P., Chen, Y., Gao, X., & Jiang, G. (2025) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-1147 · Cited by 3 · see citing works

Optimized gadolinium-DO3A loading in RAFT-polymerized copolymers for superior MR imaging of aging blood–brain barrier

Miller, H. A., Priester, A. M., Curtis, E. T., Hilmas, K., Abbott, A., Kievit, F. M., & Convertine, A. J. (2024) · Sensors & Diagnostics · doi:10.1039/d4sd00063c · Cited by 2 · see citing works

Novel Rapid In Situ Curable PEGDA/PEG Composite Hydrogel Drives Biological Closure of Aneurysm Neck

Wang, X. X., Teng, J., Cui, J., Wei, R., Zhou, S., Yan, Z., Zeng, X., Cen, W., Zhang, Z., Zhang, Y., et al. (2026) · ACS Omega · doi:10.1021/acsomega.5c09657 · Cited by 1 · see citing works

Brain Aging and Cellular Senescence Trigger Neuroimmunological Dysregulation and Neurodegeneration

Vega-García, A., Apolinar, L. M., Feria-Romero, I. A., Campos‐Bedolla, P., Alberto, G.-G. C., Luna‐Munguía, H., Sofía, R.-H., & Orozco-Suárez, S. A. (2026) · Brain Sciences · doi:10.3390/brainsci16101019 · Cited by 1 · see citing works

Imaging Techniques to Study Tight Junctions

Ali, T. A., Akhtar, S., Nisar, S., Masoodi, T., Reddy, R. D., Bhat, A. A., & Haris, M. (2023) · Springer eBooks · doi:10.1007/978-981-99-2415-8_4 · Cited by 1 · see citing works

Near-Infrared In Vivo Imaging of Claudin-1 Expression by Orthotopically Implanted Patient-Derived Colonic Adenoma Organoids

Jaiswal, S., Wang, F., Wu, X., Chang, T.-S., Shirazi, A., Lee, M., Dame, M. K., Spence, J. R., & Wang, T. D. (2024) · Diagnostics · doi:10.3390/diagnostics14030273

Pituitary Adenylate Cyclase‐Activating Polypeptide (PACAP) Pretreatment Improves Blood–Brain Barrier (BBB) Integrity in Sepsis by Activating the Wnt3a/β‐Catenin/Claudin‐1 Signaling Pathway

Han, H.-L., & Wang, G. (2025) · Peptide Science · doi:10.1002/pep2.70003

Futuristic therapeutics in pipeline for the betterment of neurodegenerative disorders

Upadhyay, H., Das, P., Sanskriti, Biswal, S., & Das, D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29932-2.00014-1

Neuroinflammation: The hidden code through the Brain

Latif, M., Noreen, S., Fatima, H., Ahmad, H., & Sheikh, N. (2025) · Albus Scientia · doi:10.56512/as.2025.1.e250508

Physiological strategies for brain delivery

Gonzalez‐Carter, D. (2026) · Advances in pharmacology · doi:10.1016/bs.apha.2026.02.007

Increased Time-Gated Eu-Centered Emission Intensity from Europium Oxide Nanoparticles Sensitized with Kynurenic Acid and Dipicolinic Acid in Tissue Samples

Wallace, J. Q., Miller, H. A., Kievit, F. M., & de Bettencourt‐Dias, A. (2026) · ACS Applied Optical Materials · doi:10.1021/acsaom.6c00062

Research advances in claudin-1 in the eye

Wang, L., Zhang, C. L., Li, N., Zhang, J., 刘玉龙, & Xu, G. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111132

Polymeric micelles as versatile shuttles: Strategic approaches for glioblastoma-targeted delivery

Verma, M., Kumar, A., Kanaujiya, S., Subhashchandra, G. K., Mittal, K., & Rajinikanth, P. S. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108622

Age-Stratified Analysis of Blood–Brain Barrier Proteins Identifies Lower Occludin Abundance in the 3xTg-AD Model

Delgado-Minjares, K. M., Flores-Maldonado, C., Campos-Blázquez, J. P., Díaz-Cintra, S. Y., Andrade-Guerrero, J., Colín-García, W., León‐Arcia, K., Martínez‐Fong, D., Contreras, R. G., & Soto-Rojas, L. O. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198705

Intracerebral Nanoparticle Transport Facilitated by Alzheimer Pathology and Age

Tracy, G. C., Huang, K.-Y., Hong, Y.-T., Ding, S., Noblet, H. A., Lim, K. H., Kim, E. C., Chung, H. J., & Kong, H. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c03222 · Cited by 24 · see citing works

The effect of ageing on the blood-brain barrier: The potential of nanoparticle drug delivery systems to target cerebrovascular changes

Bates, J. (2025) · Nottingham ePrints (University of Nottingham)

Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles

Islam, Y., Leach, A. G., Smith, J. A., Pluchino, S., Coxon, C. R., Sivakumaran, M., Downing, J. R., Fatokun, A. A., Teixidò, M., & Ehtezazi, T. (2021) · Advanced Science · doi:10.1002/advs.202002085 · Cited by 51 · see citing works

Nanoparticles as an efficient strategy to eliminate senescent brain endothelial cells

Tomé, I., Rosa, S., Sanfeliu-Redondo, D., Caramelo, F. J., Khan, A. S., Aristu-Zabalza, P., Vizioli, M. G., Pitrez, P. R., Malva, J. O., Sancho, J.-G., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115174 · Cited by 2 · see citing works

Feature Article: Polymeric Nanoparticulate Drug Delivery Through The Blood Brain Barrier

Roney, C. A., Kulkarni, P. V., Arora, V., Bennett, M., Antich, P. P., Bonte, F. J., Wu, A., Nadagouda, M. N., Manohar, S. K., Sairam, M., et al. (2005) · Polymer News · doi:10.1080/00323910500290374 · Cited by 2 · see citing works