Cylindrical micelles from the living crystallization-driven self-assembly of poly(lactide)-containing block copolymers
Abstract
The synthesis and self-assembly of poly(lactide)-b-poly(acrylic acid) and poly(lactide)-b-poly(dimethylaminoethylacrylate) block copolymers by a combination of ring-opening polymerization and reverse-addition fragmentation chain transfer (RAFT) polymerization is reported. Self-assembly of block copolymers containing enantiopure homochiral poly(lactide), PLA, by a simple direct dissolution methodology results in core-crystallization to afford micelles with a cylindrical morphology. Amorphous atactic PLA cores and conditions that did not promote crystallization resulted in spherical micelles. Cylindrical micelles were characterized by transmission electron microscopy (TEM) with cryo-TEM, small angle neutron scattering (SANS) and angular dependent dynamic light scattering (DLS) proving that the cylindrical morphology was persistent in solution. Manipulation of the assembly conditions enabled the length and dispersity of the resultant cylindrical micelles to be controlled.
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TEM results often, though not always, demonstrated agreement with cryo-TEM observations.
“whose results often (even if not always [170]) demonstrated to be in agreement with cryo-TEM observations [169,171].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [170]
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- Authors
- Petzetakis, N., Dove, A. P., & O'Reilly, R. K.
- Affiliations
- University of Warwick (GB)
- Corresponding author
- Dove, Andrew P.
- ORCID
- Dove, Andrew P.
- Venue
- Chem. Sci.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011-02-15
- Volume
- 2
- Issue
- 5
- Pages
- 955-960
- ISSN
- 2041-6520 (ISSN-L)
- 2041-6539
- OpenAlex
- W1991604237
- Cited by
- 338
- References
- 49
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 11 · 2023: 13 · 2022: 15 · 2021: 25 · 2020: 23 · 2019: 28 · 2018: 34 · 2017: 24 · 2016: 27 · 2015: 25 · 2014: 28 · 2013: 22 · 2012: 32
- FWCI
- 14.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Science (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Science and Technology Facilities Council (submittedVersion)
- Funders
- Advantage West Midlands
- Research Councils UK
- Engineering and Physical Sciences Research Council (EP/G004897/1)
- Science and Technology Facilities Council
- European Regional Development Fund
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- cylindrical micelles, block copolymers, polylactic acid, crystallization-driven self-assembly, living polymerization, RAFT polymerization, ring-opening polymerization, poly(acrylic acid), core crystallization, polymeric micelles
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