The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing
Abstract
Hypoxia, excessive reactive oxygen species (ROS), impaired angiogenesis, lasting inflammation, and bacterial infection, are key problems impeding diabetic wound healing. Particularly, controllable oxygen release and ROS scavenging capacities are critical during the wound healing process. Here, an injectable hydrogel based on hyaluronic acid- graft -dopamine (HA-DA) and polydopamine (PDA) coated Ti 3 C 2 MXene nanosheets is developed catalytically cross-linked by an oxyhemoglobin/hydrogen (HbO 2 /H 2 O 2 ) system combined with mild photothermal stimulation for diabetic wound healing. HbO 2 not only acts as a horseradish peroxidase-like to catalyze the hydrogel formation but also as an oxygen carrier to controllably release oxygen when activated by the mild heat produced from near-infrared (NIR) irradiation. Specifically, HbO 2 can provide oxygen repeatedly by binding oxygen in the air when the NIR is off. The stable photoresponsive heating behavior of MXene ensures the repeatable oxygen release. Additionally, artificial nonenzymatic antioxidant MXene nanosheets are proposed to scavenge excessive reactive nitrogen species and ROS including H 2 O 2, O 2 •–, and • OH, keeping the intracellular redox homeostasis and alleviating oxidative stress, and eradicate bacteria to avoid infection. The antioxidant and antibacterial abilities of MXene are further improved by PDA coating, which also promotes the MXene nanosheets cross-linking into the network of the hydrogel. HA-DA molecules endow the hydrogel with the capacity to regulate macrophage polarization from M1 to M2 to achieve anti-inflammation. More importantly, the MXene-anchored hydrogel with multifunctions including tissue adhesion, self-healing, injectability, and hemostasis, combined with mild photothermal stimulation, greatly promotes human umbilical vein endothelial cell proliferation and migration and notably facilitates infected diabetic wound healing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome
Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell · doi:10.1016/j.cell.2014.11.047 · Cited by 1,014
Zhang, F.-X., Liu, P., Ding, W., Meng, Q.-B., Su, D.-H., Zhang, Q.-C., Lian, R.-X., Yu, B.-Q., Zhao, M.-D., Dong, J., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121169 · Cited by 328
Self-citationLiu, H., Hu, Z., Liu, Q., Sun, P., Wang, Y., Chou, S., Hu, Z., & Zhang, Z. (2020) · Journal of Materials Chemistry A · doi:10.1039/d0ta09538a · Cited by 176
Cited by
Zhou, X., Ning, X., Chen, Y., Chang, H., Lu, D., Pei, D., Geng, Z., Zeng, Z., Guo, C., Huang, J., et al. (2023) · ACS Materials Letters · doi:10.1021/acsmaterialslett.3c00925 · Cited by 127
Separable Microneedles with Photosynthesis-Driven Oxygen Manufactory for Diabetic Wound Healing
Zhao, E., Xiao, T., Tan, Y., Zhou, X., Li, Y., Wang, X., Zhang, K., Ou, C., Zhang, J., Li, Z., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c18809 · Cited by 88
Self-citationZhu, S., Dou, W., Zeng, X., Chen, X., Gao, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105249 · Cited by 28
Wu, M., Wang, Y., Liu, H., Chen, F., Zhang, Y., Wu, P., Deng, Z., & Cai, L. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.111705 · Cited by 28
Metadata
- Authors
- Li, Y., Fu, R., Duan, Z., Zhu, C., & Fan, D.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-05-09
- Volume
- 16
- Issue
- 5
- Pages
- 7486-7502
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4229451865
- Cited by
- 634
- References
- 4
- FWCI
- 48.86
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing. https://app.cochat.ai/papers/10.1021/acsnano.1c10575
- The paper
- Li, Y., Fu, R., Duan, Z., Zhu, C., & Fan, D. (2022). Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing. ACS Nano. https://doi.org/10.1021/acsnano.1c10575
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
