The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine
Open accessAbstract
Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT and PTT at the cellular, vascular and tumor microenvironmental levels, as well as translating both modalities in the clinic. Emerging evidence suggests that PDT and PTT may synergize due to their different mechanisms of action, and their nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations have gained momentum in recent years due to the development of multimodal nanoplatforms that simultaneously incorporate photodynamically- and photothermally active agents. In this review, we discuss how combining PDT and PTT can address the limitations of each modality alone and enhance treatment safety and efficacy. We provide an overview of recent literature featuring dual PDT/PTT nanoparticles and analyze the strengths and limitations of various nanoparticle design strategies. We also detail how treatment sequence and dose may affect cellular states, tumor pathophysiology and drug delivery, ultimately shaping the treatment response. Lastly, we analyze common experimental design pitfalls that complicate preclinical assessment of PDT/PTT combinations and propose rational guidelines to elucidate the mechanisms underlying PDT/PTT interactions.
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Cites
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Self-citationLipid nanoparticles for mRNA delivery
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Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors
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Light Sources and Dosimetry Techniques for Photodynamic Therapy
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Supramolecular cancer nanotheranostics
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Cited by
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Hu, D., Li, Y., Li, R., Wang, M., Zhou, K., He, C., Wei, Q., & Qian, Z. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.015 · Cited by 153
Zhu, L., Song, G., Zhang, W., Wu, Y., Chen, Y., Song, J., Wang, D., Li, G., Tang, B. Z., & Li, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-57533-y · Cited by 63
Recent advances in near-infrared-II organic J-aggregates for bio-applications
Xu, J., Zheng, X., Ren, T.-B., Shi, L., Yin, X., Yuan, L., & Zhang, X.-B. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216379 · Cited by 48
Advances on fluorescence bioimaging and photo-mediated therapy of NIR-II small molecule dyes
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Metadata
- Authors
- Overchuk, M., Weersink, R. A., Wilson, B. C., & Zheng, G.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-04-27
- Volume
- 17
- Issue
- 9
- Pages
- 7979-8003
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4367180472
- Cited by
- 1,323
- References
- 8
- FWCI
- 97.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Overchuk, M., Weersink, R. A., Wilson, B. C., & Zheng, G. (2023). Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine. ACS Nano. https://doi.org/10.1021/acsnano.3c00891
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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