The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity
Abstract
To predict potential medical value or toxicity of nanoparticles (NPs), it is necessary to understand the chemical transformation during intracellular processes of NPs. However, it is a grand challenge to capture a high-resolution image of metallic NPs in a single cell and the chemical information on intracellular NPs. Here, by integrating synchrotron radiation-beam transmission X-ray microscopy (SR-TXM) and SR-X-ray absorption near edge structure (SR-XANES) spectroscopy, we successfully capture the 3D distribution of silver NPs (AgNPs) inside a single human monocyte (THP-1), associated with the chemical transformation of silver. The results reveal that the cytotoxicity of AgNPs is largely due to the chemical transformation of particulate silver from elemental silver (Ag(0))n, to Ag(+) ions and Ag-O-, then Ag-S- species. These results provide direct evidence in the long-lasting debate on whether the nanoscale or the ionic form dominates the cytotoxicity of silver nanoparticles. Further, the present approach provides an integrated strategy capable of exploring the chemical origins of cytotoxicity in metallic nanoparticles.
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Self-citationDynamic protein coronas revealed as a modulator of silver nanoparticle sulphidation in vitro
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Length and diameter-dependent phagocytosis and cytotoxicity of long silver nanowires in macrophages
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Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer
Mousazadeh, N., Seidi, F., Ghaffarlou, M., Rashidzadeh, H., Hosseinmirzaei, A., Mozafari, F., Danafar, H., & Nosrati, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123636 · Cited by 13
Metadata
- Authors
- Wang, L., Zhang, T., Li, P., Huang, W., Tang, J., Wang, P., Liu, J., Yuan, Q., Bai, R., Li, B., Zhang, K., Zhao, Y., & Chen, C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-05-29
- Volume
- 9
- Issue
- 6
- Pages
- 6532-6547
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W255442691
- Cited by
- 290
- References
- 77
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
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