Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties

Liposomal drug delivery systems: From concept to clinical applications

Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839 · see citing works

Selective inhibition of BET bromodomains

Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature · doi:10.1038/nature09504 · Cited by 4,262 · see citing works

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 3,037 · see citing works

A practical Bayesian framework for backpropagation networks

MacKay, D. J. C. (1992) · Neural Computation · doi:10.1162/neco.1992.4.3.448 · Cited by 2,917 · see citing works

A constrained regularization method for inverting data represented by linear algebraic or integral equations

Provencher, S. W. (1982) · Computer Physics Communications · doi:10.1016/0010-4655(82)90173-4 · Cited by 2,704 · see citing works

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

Tenzer, S., Docter, D., Kuharev, J., Musyanovych, A., Fetz, V., Hecht, R., Schlenk, F., Fischer, D., Kiouptsi, K., Reinhardt, C., et al. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.181 · Cited by 2,283 · see citing works

Principles of QSAR models validation: internal and external

Gramatica, P. (2007) · QSAR & Combinatorial Science · doi:10.1002/qsar.200610151 · Cited by 2,229 · see citing works

The Importance of Being Earnest: Validation is the Absolute Essential for Successful Application and Interpretation of QSPR Models

Tropsha, A., Gramatica, P., & Gombar, V. K. (2003) · QSAR & Combinatorial Science · doi:10.1002/qsar.200390007 · Cited by 2,195 · see citing works

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758 · see citing works

Protein-nanoparticle interactions

Lynch, I., & Dawson, K. A. (2008) · Nano Today · doi:10.1016/s1748-0132(08)70014-8 · Cited by 1,734 · see citing works

Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs.

Eriksson, L., Jaworska, J., Worth, A. P., Cronin, M. T. D., McDowell, R. M., & Gramatica, P. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5758 · Cited by 1,325 · see citing works

What the Cell “Sees” in Bionanoscience

Dorota, W., Bombelli, F. B., Monopoli, M. P., Lynch, I., & Dawson, K. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910675v · Cited by 1,188 · see citing works

Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

Tenzer, S., Docter, D., Rosfa, S., Wlodarski, A., Kuharev, J., Rekik, A., Knauer, S. K., Bantz, C., Nawroth, T., Bier, C., et al. (2011) · ACS Nano · doi:10.1021/nn201950e · Cited by 854 · see citing works

Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles

Walkey, C., Olsen, J. B., Song, F., Liu, R., Guo, H., Olsen, D. W. H., Cohen, Y., Emili, A., & Chan, W. C. W. (2014) · ACS Nano · doi:10.1021/nn406018q · Cited by 824 · see citing works

Variable selection in regression—a tutorial

Andersen, C. M., & Bro, R. (2010) · Journal of Chemometrics · doi:10.1002/cem.1360 · Cited by 698 · see citing works

Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine

Al-Jamal, W. T., & Kostarelos, K. (2011) · Accounts of Chemical Research · doi:10.1021/ar200105p · Cited by 697 · see citing works

Practical Guide To Chemometrics

Gemperline, P. (2006) · CRC Press eBooks · doi:10.1201/9781420018301 · Cited by 640 · see citing works

Polymer-Coated Nanoparticles Interacting with Proteins and Cells: Focusing on the Sign of the Net Charge

Hühn, D., Kantner, K., Geidel, C., Brandholt, S., Cock, I. D., Soenen, S. J., Rivera-Gil, P., Montenegro, J., Braeckmans, K., Müllen, K., et al. (2013) · ACS Nano · doi:10.1021/nn3059295 · Cited by 582 · see citing works

Effect of polyethyleneglycol (PEG) chain length on the bio–nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells

Pozzi, D., Colapicchioni, V., Caracciolo, G., Piovesana, S., Capriotti, A. L., Palchetti, S., De Grossi, S., Riccioli, A., Amenitsch, H., & Laganà, A. (2014) · Nanoscale · doi:10.1039/c3nr05559k · Cited by 581 · see citing works

What does the cell see?

Lynch, I., Salvati, A. L., & Dawson, K. A. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.248 · Cited by 553 · see citing works

Temperature: The “Ignored” Factor at the NanoBio Interface

Mahmoudi, M., Abdelmonem, A. M., Behzadi, S., Clement, J. H., Dutz, S., Ejtehadi, M. R., Hartmann, R., Kantner, K., Linne, U., Maffre, P., et al. (2013) · ACS Nano · doi:10.1021/nn305337c · Cited by 334 · see citing works

Personalized protein coronas: a “key” factor at the nanobiointerface

Hajipour, M. J., Laurent, S., Aghaie, A., Rezaee, F., & Mahmoudi, M. (2014) · Biomaterials Science · doi:10.1039/c4bm00131a · Cited by 309 · see citing works

Time Evolution of Nanoparticle–Protein Corona in Human Plasma: Relevance for Targeted Drug Delivery

Barrán-Berdón, A. L., Pozzi, D., Caracciolo, G., Capriotti, A. L., Caruso, G., Cavaliere, C., Anna Riccioli, A., Palchetti, S., & Laganà, A. (2013) · Langmuir · doi:10.1021/la401192x · Cited by 290 · see citing works

Toward the Development of “Nano‐QSARs”: Advances and Challenges

Puzyn, T., Leszczyńska, D., & Leszczyński, J. (2009) · Small · doi:10.1002/smll.200900179 · Cited by 247 · see citing works

Liposome–protein corona in a physiological environment: Challenges and opportunities for targeted delivery of nanomedicines

Caracciolo, G. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.11.003 · Cited by 246 · see citing works

The biomolecular corona of nanoparticles in circulating biological media

Pozzi, D., Caracciolo, G., Digiacomo, L., Colapicchioni, V., Palchetti, S., Capriotti, A. L., Cavaliere, C., Chiozzi, R. Z., Puglisi, A., & Laganà, A. (2015) · Nanoscale · doi:10.1039/c5nr03701h · Cited by 163 · see citing works

Prediction of nanoparticles-cell association based on corona proteins and physicochemical properties

Liu, R., Jiang, W., Walkey, C., Chan, W. C. W., & Cohen, Y. (2015) · Nanoscale · doi:10.1039/c5nr01537e · Cited by 147 · see citing works

Antagonizing STAT3 Dimerization with a Rhodium(III) Complex

Ma, D., Liu, L., Leung, K., Chen, Y., Zhong, H., Chan, D. S., Wang, H., & Leung, C. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201404686 · Cited by 123 · see citing works

The liposome–protein corona in mice and humans and its implications for in vivo delivery

Caracciolo, G., Pozzi, D., Capriotti, A. L., Cavaliere, C., Piovesana, S., Barbera, G. L., Amici, A. R. D., & Laganà, A. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01316f · Cited by 118 · see citing works

Antagonizing STAT3 Dimerization with a Rhodium(III) Complex

Ma, D., Liu, L., Leung, K., Chen, Y., Zhong, H., Chan, D. S., Wang, H., & Leung, C. (2014) · Angewandte Chemie · doi:10.1002/ange.201404686 · Cited by 109 · see citing works

Evolution of the Protein Corona of Lipid Gene Vectors as a Function of Plasma Concentration

Caracciolo, G., Pozzi, D., Capriotti, A. L., Cavaliere, C., Foglia, P., Amenitsch, H. W., & Laganà, A. (2011) · Langmuir · doi:10.1021/la202912f · Cited by 106 · see citing works

Interpreting Computational Neural Network QSAR Models: A Measure of Descriptor Importance

Guha, R., & Jurs, P. C. (2005) · Journal of Chemical Information and Modeling · doi:10.1021/ci050022a · Cited by 98 · see citing works

Tracking protein corona over time

Lundqvist, M. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.196 · Cited by 84 · see citing works

Do plasma proteins distinguish between liposomes of varying charge density?

Capriotti, A. L., Caracciolo, G., Cavaliere, C., Foglia, P., Pozzi, D., Samperi, R., & Laganà, A. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.01.003 · Cited by 70 · see citing works

Cellular binding of nanoparticles in the presence of serum proteins

Doorley, G. W., & Payne, C. K. (2010) · Chemical Communications · doi:10.1039/c0cc02618b · Cited by 64 · see citing works

General introduction

Lasiç, D. D., & Papahadjopoulos, D. (1998) · Elsevier eBooks · doi:10.1016/b978-044482917-7/50001-6 · Cited by 13 · see citing works

Cancer nanomedicine: progress, challenges and opportunities

Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works

Protein corona: a new approach for nanomedicine design

Nguyen, V. H., & Lee, B. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s129300 · Cited by 640 · see citing works

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 601 · see citing works

Brain-targeted drug delivery by manipulating protein corona functions

Zhang, Z., Guan, J., Jiang, Z., Yang, Y., Liu, J., Hua, W., Mao, Y., Li, C., Lu, W., Qian, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11593-z · Cited by 334 · see citing works

Personalized protein corona on nanoparticles and its clinical implications

Corbo, C., Molinaro, R., Tabatabaei, M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Biomaterials Science · doi:10.1039/c6bm00921b · Cited by 314 · see citing works

Targeted liposomal drug delivery: a nanoscience and biophysical perspective

Liu, Y., Bravo, K. M. C., & Liu, J. (2020) · Nanoscale Horizons · doi:10.1039/d0nh00605j · Cited by 300 · see citing works

Interplay of protein corona and immune cells controls blood residency of liposomes

Giulimondi, F., Digiacomo, L., Pozzi, D., Palchetti, S., Vulpis, E., Capriotti, A. L., Chiozzi, R. Z., Laganà, A., Amenitsch, H. W., Masuelli, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11642-7 · Cited by 271 · see citing works

Nanomedicines for renal disease: current status and future applications

Kamaly, N., He, C., Ausiello, D. A., & Farokhzad, O. C. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.156 · Cited by 253 · see citing works

Recent advances and clinical translation of liposomal delivery systems in cancer therapy

Chen, J., Hu, S., Sun, M., Shi, J., Zhang, H., Yu, H., & Yang, Z. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106688 · Cited by 229 · see citing works

Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery

Gause, K. T., Wheatley, A. K., Cui, J., Yan, Y., Kent, S. J., & Caruso, F. (2017) · ACS Nano · doi:10.1021/acsnano.6b07343 · Cited by 198 · see citing works

Peptide ligand-mediated targeted drug delivery of nanomedicines

Jiang, Z., Guan, J., Qian, J., & Zhan, C. (2019) · Biomaterials Science · doi:10.1039/c8bm01340c · Cited by 179 · see citing works

Debugging Nano–Bio Interfaces: Systematic Strategies to Accelerate Clinical Translation of Nanotechnologies

Mahmoudi, M. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.02.014 · Cited by 167 · see citing works

Techniques for the experimental investigation of the protein corona

Carrillo‐Carrión, C., Carril, M., & Parak, W. J. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.02.009 · Cited by 158 · see citing works

Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

Guan, J., Shen, Q., Zhang, Z., Jiang, Z., Yang, Y., Lou, M., Qian, J., Lu, W., & Zhan, C. (2018) · Nature Communications · doi:10.1038/s41467-018-05384-1 · Cited by 152 · see citing works

Multiscale technologies for treatment of ischemic cardiomyopathy

Mahmoudi, M., Yu, M., Serpooshan, V., Wu, J. C., Langer, R., Lee, R. T., Karp, J. M., & Farokhzad, O. C. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.167 · Cited by 138 · see citing works

Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects

Cheng, Z., Huang, H., Yin, M., & Liu, H. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00602-1 · Cited by 155 · see citing works

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

Zielińska, A., Alves, H. G. R., Marques, V., Durazzo, A., Lucarini, M., Alves, T., Morsink, M. A. J., Willemen, N. G. A., Eder, P., Chaud, M. V., et al. (2020) · Medicina · doi:10.3390/medicina56070336 · Cited by 122 · see citing works

Disease-specific protein corona sensor arrays may have disease detection capacity

Caracciolo, G., Safavi‐Sohi, R., Malekzadeh, R., Poustchi, H., Vasighi, M., Chiozzi, R. Z., Capriotti, A. L., Laganà, A., Hajipour, M. J., Domenico, M. D., et al. (2019) · Nanoscale Horizons · doi:10.1039/c9nh00097f · Cited by 113 · see citing works

Characterization of nanomedicines: A reflection on a field under construction needed for clinical translation success

Coty, J.-B., & Vauthier, C. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.013 · Cited by 114 · see citing works

An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles

Digiacomo, L., Cardarelli, F., Pozzi, D., Palchetti, S., Digman, M. A., Gratton, E., Capriotti, A. L., Mahmoudi, M., & Caracciolo, G. (2017) · Nanoscale · doi:10.1039/c7nr06437c · Cited by 109 · see citing works

One Stone Four Birds: A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy

Hong, C., Liang, J., Xia, J., Zhu, Y., Guo, Y., Wang, A., Lu, C.-Y. D., Ren, H., Chen, C., Li, S., et al. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-00472-8 · Cited by 106 · see citing works

Clinically approved liposomal nanomedicines: lessons learned from the biomolecular corona

Caracciolo, G. (2018) · Nanoscale · doi:10.1039/c7nr07450f · Cited by 106 · see citing works

Influence of dynamic flow environment on nanoparticle-protein corona: From protein patterns to uptake in cancer cells

Palchetti, S., Pozzi, D., Capriotti, A. L., Barbera, G. L., Chiozzi, R. Z., Digiacomo, L., Peruzzi, G., Caracciolo, G., & Laganà, A. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.02.037 · Cited by 105 · see citing works

Clinically approved PEGylated nanoparticles are covered by a protein corona that boosts the uptake by cancer cells

Papi, M., Caputo, D. D., Palmieri, V., Coppola, R., Palchetti, S., Bugli, F., Martini, C., Digiacomo, L., Pozzi, D., & Caracciolo, G. (2017) · Nanoscale · doi:10.1039/c7nr03042h · Cited by 98 · see citing works

Plasma Protein Adsorption and Biological Identity of Systemically Administered Nanoparticles

Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0178 · Cited by 97 · see citing works

A protein corona-enabled blood test for early cancer detection

Caputo, D. D., Papi, M., Coppola, R., Palchetti, S., Digiacomo, L., Caracciolo, G., & Pozzi, D. (2016) · Nanoscale · doi:10.1039/c6nr05609a · Cited by 95 · see citing works

In silico profiling nanoparticles: predictive nanomodeling using universal nanodescriptors and various machine learning approaches

Yan, X., Sedykh, A., Wang, W., Zhao, X., Yan, B., & Zhu, H. (2019) · Nanoscale · doi:10.1039/c9nr00844f · Cited by 95 · see citing works

Impact of the protein corona on nanomaterial immune response and targeting ability

Digiacomo, L., Pozzi, D., Palchetti, S., Zingoni, A., & Caracciolo, G. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1615 · Cited by 96 · see citing works

The impact of protein corona on the biological behavior of targeting nanomedicines

Farshbaf, M., Valizadeh, H., Panahi, Y., Fatahi, Y., Chen, M., Zarebkohan, A., & Gao, H. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121458 · Cited by 95 · see citing works

Combined photothermal and antibiotic therapy for bacterial infection via acidity-sensitive nanocarriers with enhanced antimicrobial performance

He, D., Yang, T., Qian, W., Qi, C., Li, M., Yu, X., Zhu, H.-F., Luo, G., & Deng, J. (2018) · Applied Materials Today · doi:10.1016/j.apmt.2018.07.006 · Cited by 95 · see citing works

Functionalization of Liposomes with Hydrophilic Polymers Results in Macrophage Uptake Independent of the Protein Corona

Weber, C., Voigt, M., Simon, J., Danner, A., Frey, H., Mailänder, V., Helm, M., Morsbach, S., & Landfester, K. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00539 · Cited by 94 · see citing works

Nanoparticles-cell association predicted by protein corona fingerprints

Palchetti, S., Digiacomo, L., Pozzi, D., Peruzzi, G., Micarelli, E., Mahmoudi, M., & Caracciolo, G. (2016) · Nanoscale · doi:10.1039/c6nr03898k · Cited by 92 · see citing works

Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network

Vu, M. N., Kelly, H. G., Wheatley, A. K., Peng, S., Pilkington, E. H., Veldhuis, N. A., Davis, T. P., Kent, S. J., & Truong, N. P. (2020) · Small · doi:10.1002/smll.202002861 · Cited by 88 · see citing works

Converting Nanotoxicity Data to Information Using Artificial Intelligence and Simulation

Yan, X., Yue, T., Winkler, D. A., Yin, Y., Zhu, H., Jiang, G., & Yan, B. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00070 · Cited by 88 · see citing works

Chiral polymer modified nanoparticles selectively induce autophagy of cancer cells for tumor ablation

Yuan, L., Zhang, F., Qi, X., Yang, Y., Yan, C., Jiang, J., & Deng, J. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0383-9 · Cited by 86 · see citing works

Tuning liposome composition to modulate corona formation in human serum and cellular uptake

Yang, K., Mesquita, B. S., Horvatovich, P. L., & Salvati, A. L. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.02.018 · Cited by 83 · see citing works

Spotlight on the protein corona of liposomes

Onishchenko, N. R., Tretiakova, D. S., & Vodovozova, E. L. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.07.074 · Cited by 81 · see citing works

The Janus of Protein Corona on nanoparticles for tumor targeting, immunotherapy and diagnosis

Wang, X., & Zhang, W. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.056 · Cited by 81 · see citing works

Incorporating gold nanoclusters and target-directed liposomes as a synergistic amplified colorimetric sensor for HER2-positive breast cancer cell detection

Tao, Y., Li, M., Kim, B., & Auguste, D. T. (2017) · Theranostics · doi:10.7150/thno.17927 · Cited by 80 · see citing works

Photodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity

Plenagl, N., Duse, L., Seitz, B. S., Goergen, N., Pinnapireddy, S. R., Jedelská, J., Brüßler, J., & Bakowsky, U. (2019) · Drug Delivery · doi:10.1080/10717544.2018.1531954 · Cited by 79 · see citing works

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Khan, S., Sharifi, M., Gleghorn, J. P., Babadaei, M. M. N., Bloukh, S. H., Edis, Z., Amin, M., Bai, Q., ten Hagen, T. L. M., Falahati, M., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.055 · Cited by 78 · see citing works

Brain Targeting by Liposome–Biomolecular Corona Boosts Anticancer Efficacy of Temozolomide in Glioblastoma Cells

Arcella, A., Palchetti, S., Digiacomo, L., Pozzi, D., Capriotti, A. L., Frati, L., Oliva, M. A., Tsaouli, G., Rota, R., Screpanti, I., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00339 · Cited by 77 · see citing works

A facile approach for the reduction of 4‑nitrophenol and degradation of congo red using gold nanoparticles or laccase decorated hybrid inorganic nanoparticles/polymer-biomacromolecules vesicles

Wu, G., Liu, X., Zhou, P., Wang, L., Hegazy, M., Huang, X. C., & Huang, Y. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.09.061 · Cited by 77 · see citing works

Looking Back, Moving Forward: Lipid Nanoparticles as a Promising Frontier in Gene Delivery

Pozzi, D., & Caracciolo, G. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00185 · Cited by 74 · see citing works

Correlating Corona Composition and Cell Uptake to Identify Proteins Affecting Nanoparticle Entry into Endothelial Cells

Aliyandi, A., Reker‐Smit, C., Bron, R., Zuhorn, I. S., & Salvati, A. L. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00804 · Cited by 71 · see citing works

Translation of nanomedicines from lab to industrial scale synthesis: The case of squalene-adenosine nanoparticles

Dormont, F., Rouquette, M., Mahatsekake, C., Gobeaux, F., Peramo, A., Brusini, R., Calet, S., Testard, F., Lepêtre‐Mouelhi, S., Desmaële, D., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.06.040 · Cited by 65 · see citing works

A nanoinformatics decision support tool for the virtual screening of gold nanoparticle cellular association using protein corona fingerprints

Afantitis, A., Melagraki, G., Tsoumanis, A., Valsami‐Jones, E., & Lynch, I. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1504998 · Cited by 58 · see citing works

The biomolecular corona of gold nanoparticles in a controlled microfluidic environment

Digiacomo, L., Palchetti, S., Giulimondi, F., Pozzi, D., Chiozzi, R. Z., Capriotti, A. L., Laganà, A., & Caracciolo, G. (2019) · Lab on a Chip · doi:10.1039/c9lc00341j · Cited by 58 · see citing works

Protein Corona Fingerprints of Liposomes: New Opportunities for Targeted Drug Delivery and Early Detection in Pancreatic Cancer

Palchetti, S., Caputo, D. D., Digiacomo, L., Capriotti, A. L., Coppola, R., Pozzi, D., & Caracciolo, G. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11010031 · Cited by 57 · see citing works

Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins

Tian, Y. P., Tirrell, M., & LaBelle, J. L. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102600 · Cited by 51 · see citing works

Peptide-decorated nanocarriers penetrating the blood-brain barrier for imaging and therapy of brain diseases

Gao, X., Xu, J., Yao, T., Liu, X., Zhang, H., & Zhan, C. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114362 · Cited by 55 · see citing works

Methods of protein corona isolation for magnetic nanoparticles

Bonvin, D., Chiappe, D., Moniatte, M., Hofmann, H., & Ebersold, M. M. (2017) · The Analyst · doi:10.1039/c7an00646b · Cited by 52 · see citing works

Natural IgM dominates in vivo performance of liposomes

Ding, T., Guan, J., Wang, M., Long, Q., Liu, X., Qian, J., Wei, X., Lu, W., & Zhan, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.018 · Cited by 52 · see citing works

Small molecule modulation of protein corona for deep plasma proteome profiling

Ashkarran, A. A., Gharibi, H., Sadeghi, S. A., Modaresi, S. M., Wang, Q., Lin, T.-J., Yerima, G., Tamadon, A., Sayadi, M., Jafari, M. T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53966-z · Cited by 51 · see citing works

A Nanomedicine Structure–Activity Framework for Research, Development, and Regulation of Future Cancer Therapies

Youden, B., Jiang, R., Carrier, A. J., Servos, M. R., & Zhang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c06337 · Cited by 51 · see citing works

Deciphering Protein Corona by scFv-Based Affinity Chromatography

Chu, Y., Tang, W., Zhang, Z., Li, C., Qian, J., Wei, X., Ying, T., Lu, W., & Zhan, C. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04806 · Cited by 50 · see citing works

Tuning the immune system by nanoparticle–biomolecular corona

Palmieri, V., & Caracciolo, G. (2022) · Nanoscale Advances · doi:10.1039/d2na00290f · Cited by 50 · see citing works

Sensing of Alzheimer’s Disease and Multiple Sclerosis Using Nano-Bio Interfaces

Hajipour, M. J., Ghasemi, F., Aghaverdi, H., Raoufi, M., Linne, U., Atyabi, F., Nabipour, I., Azhdarzadeh, M., Derakhshankhah, H., Lotfabadi, A., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160206 · Cited by 47 · see citing works

Protein corona: challenges and opportunities for targeted delivery of nanomedicines

Jiang, Z., Chu, Y., & Zhan, C. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2093854 · Cited by 46 · see citing works

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Costa, C., Liu, Z., Martins, J. P., Correia, A., Figueiredo, P., Rahikkala, A., Li, W., Seitsonen, J. J. T., Ruokolainen, J., Hirvonen, S.-P., et al. (2020) · Biomaterials Science · doi:10.1039/d0bm00743a · Cited by 44 · see citing works

Binding of human serum albumin to PEGylated liposomes: insights into binding numbers and dynamics by fluorescence correlation spectroscopy

Kristensen, K., Urquhart, A. J., Thormann, E., & Andresen, T. L. (2016) · Nanoscale · doi:10.1039/c6nr05455b · Cited by 43 · see citing works

Biological and environmental surface interactions of nanomaterials: characterization, modeling, and prediction

Chen, R., & Riviere, J. E. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1440 · Cited by 43 · see citing works

Protein Corona: Impact of Lymph Versus Blood in a Complex In Vitro Environment

Bonvin, D., Aschauer, U., Alexander, D. T. L., Chiappe, D., Moniatte, M., Hofmann, H., & Ebersold, M. M. (2017) · Small · doi:10.1002/smll.201700409 · Cited by 43 · see citing works

A novel multi-functionalized multicellular nanodelivery system for non-small cell lung cancer photochemotherapy

Zhang, Y., Xia, Q., Wu, T. S., He, Z., Li, Y., Li, Z., Hou, X., He, Y., Ruan, S., Wang, Z., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00977-3 · Cited by 42 · see citing works

Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio–Nano Interface

Simpson, J. D., Smith, S. A., Thurecht, K. J., & Such, G. K. (2019) · Polymers · doi:10.3390/polym11091441 · Cited by 39 · see citing works

A comprehensive review of nano drug delivery system in the treatment of CNS disorders

Spandana, K. M. A., Bhaskaran, M., Karri, V. V. S. N. R., & Natarajan, J. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101628 · Cited by 39 · see citing works

Performance of nanoparticles for biomedical applications: The in vitro / in vivo discrepancy

Berger, S., Berger, M., Bantz, C., Maskos, M., & Wagner, E. (2022) · Biophysics Reviews · doi:10.1063/5.0073494 · Cited by 38 · see citing works

Rational nanocarrier design towards clinical translation of cancer nanotherapy

Guo, D., Ji, X., & Luo, J. (2021) · Biomedical Materials · doi:10.1088/1748-605x/abe35a · Cited by 39 · see citing works

Interplay between nanomedicine and protein corona

Yang, M., Wu, E., Tang, W., Qian, J., & Zhan, C. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01063h · Cited by 38 · see citing works

Liposome protein corona characterization as a new approach in nanomedicine

Capriotti, A. L., Cavaliere, C., & Piovesana, S. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-01656-x · Cited by 37 · see citing works

Potential clinical applications of the personalized, disease-specific protein corona on nanoparticles

García-Vence, M., Chantada‐Vázquez, M. D. P., Vázquez‐Estévez, S., Cameselle‐Teijeiro, J., Bravo, S. B., & Núñez, C. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.10.027 · Cited by 37 · see citing works

A decade of the liposome-protein corona: Lessons learned and future breakthroughs in theranostics

Quagliarini, E., Digiacomo, L., Renzi, S., Pozzi, D., & Caracciolo, G. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101657 · Cited by 35 · see citing works

Exploitation of nanoparticle–protein corona for emerging therapeutic and diagnostic applications

Palchetti, S., Pozzi, D., Mahmoudi, M., & Caracciolo, G. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01095d · Cited by 35 · see citing works

Nanotechnology-based delivery systems to overcome drug resistance in cancer

Patel, H. H., Li, J., Bo, L., Mehta, R., Ashby, C. R., Wang, S., Cai, W., & Chen, Z. (2024) · Medical Review · doi:10.1515/mr-2023-0058 · Cited by 35 · see citing works

Interactions of plant food bioactives‐loaded nano delivery systems at the nano‐bio interface and its pharmacokinetics: An overview

Shanmugam, H., Rengarajan, C., Nataraj, S., & Sharma, A. (2022) · Food Frontiers · doi:10.1002/fft2.130 · Cited by 34 · see citing works

Isolation methods commonly used to study the liposomal protein corona suffer from contamination issues

Kristensen, K., Münter, R., Kempen, P. J., Thomsen, M. E., Stensballe, A., & Andresen, T. L. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.008 · Cited by 33 · see citing works

Detecting the shape of anisotropic gold nanoparticles in dispersion with single particle extinction and scattering

Potenza, M. A. C., Krpetić, Ž., Sanvito, T., Cai, Q., Monopoli, M. P., de Araújo, J. M., Cella, C., Boselli, L., Castagnola, V., Milani, P., et al. (2017) · Nanoscale · doi:10.1039/c6nr08977a · Cited by 33 · see citing works

The Transformative Potential of Lipid Nanoparticle–Protein Corona for Next-Generation Vaccines and Therapeutics

Amici, A. R. D., Pozzi, D., Marchini, C., & Caracciolo, G. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00479 · Cited by 32 · see citing works

In vivo tailor-made protein corona of a prodrug-based nanoassembly fabricated by redox dual-sensitive paclitaxel prodrug for the superselective treatment of breast cancer

Zhang, D., Yang, J., Guan, J., Yang, B., Zhang, S., Sun, M., Yang, R., Zhang, T., Zhang, R., Kan, Q., et al. (2018) · Biomaterials Science · doi:10.1039/c8bm00548f · Cited by 32 · see citing works

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Atkinson, S. P., Andreu, Z., & Vicent, M. J. (2018) · Journal of Personalized Medicine · doi:10.3390/jpm8010006 · Cited by 30 · see citing works

Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes

Nummelin, S., Selin, M., Legrand, S., Ropponen, J., Seitsonen, J. J. T., Nykänen, A., Koivisto, J. J., Hirvonen, J. J., Kostiainen, M. A., & Bimbo, L. M. (2017) · Nanoscale · doi:10.1039/c6nr08102a · Cited by 30 · see citing works

Impact of the biomolecular corona on the structure of PEGylated liposomes

Digiacomo, L., Pozzi, D., Amenitsch, H. W., & Caracciolo, G. (2017) · Biomaterials Science · doi:10.1039/c7bm00387k · Cited by 29 · see citing works

Exploitation of nanoparticle-protein interactions for early disease detection

Papi, M., Palmieri, V., Palchetti, S., Pozzi, D., Digiacomo, L., Guadagno, E., De, M. D. B., Domenico, M. D., Ricci, S., Pani, R., et al. (2019) · Applied Physics Letters · doi:10.1063/1.5098081 · Cited by 29 · see citing works

Analysis of model PM2.5-induced inflammation and cytotoxicity by the combination of a virtual carbon nanoparticle library and computational modeling

Liu, G., Yan, X., Sedykh, A., Pan, X., Zhao, X., Yan, B., & Zhu, H. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110216 · Cited by 29 · see citing works

Evidence of Protein Adsorption in Pegylated Liposomes: Influence of Liposomal Decoration

Sangrà, M., Estelrich, J., Sabaté, R., Espargaró, A., & Busquets, M. A. (2017) · Nanomaterials · doi:10.3390/nano7020037 · Cited by 28 · see citing works

Regulation of in vivo behavior of TAT-modified liposome by associated protein corona and avidity to tumor cells

Amin, M., Bagheri, M., Mansourian, M., Jaafari, M. R., & ten Hagen, T. L. M. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s170274 · Cited by 28 · see citing works

Disentangling Biomolecular Corona Interactions With Cell Receptors and Implications for Targeting of Nanomedicines

Aliyandi, A., Zuhorn, I. S., & Salvati, A. L. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.599454 · Cited by 28 · see citing works

Chelating agents as coating molecules for iron oxide nanoparticles

Bonvin, D., Bastiaansen, J., Stuber, M., Hofmann, H., & Ebersold, M. M. (2017) · RSC Advances · doi:10.1039/c7ra08217g · Cited by 25 · see citing works

Resolving Single-Nanoconstruct Dynamics during Targeting and Nontargeting Live-Cell Membrane Interactions

Bhowmik, D., Culver, K. S. B., Liu, T., & Odom, T. W. (2019) · ACS Nano · doi:10.1021/acsnano.9b03144 · Cited by 25 · see citing works

Concentration and composition of the protein corona as a function of incubation time and serum concentration: an automated approach to the protein corona

Poulsen, K. M., & Payne, C. K. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04278-y · Cited by 24 · see citing works

Effect of molecular crowding on the biological identity of liposomes: an overlooked factor at the bio-nano interface

Digiacomo, L., Giulimondi, F., Mahmoudi, M., & Caracciolo, G. (2019) · Nanoscale Advances · doi:10.1039/c9na00195f · Cited by 24 · see citing works

On the Virtues of Automated Quantitative Structure–Activity Relationship: The New Kid on the Block

de Oliveira, M. T., & Katekawa, E. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0170 · Cited by 24 · see citing works

Mechanistic Insights into the Superior DNA Delivery Efficiency of Multicomponent Lipid Nanoparticles: An In Vitro and In Vivo Study

Quagliarini, E., Wang, J., Renzi, S., Cui, L., Digiacomo, L., Ferri, G., Pesce, L., Lorenzi, V. D., Matteoli, G., Amenitsch, H. W., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c20019 · Cited by 22 · see citing works

Aggregation and Protein Corona Formation on Gold Nanoparticles Affect Viability and Liver Functions of Primary Rat Hepatocytes

Koh, W. L., Tham, H. P., Yu, H., Leo, H. L., & Kah, J. C. Y. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0173 · Cited by 22 · see citing works

Protein corona-enabled serological tests for early stage cancer detection

Quagliarini, E., Santo, R. D., Pozzi, D., & Caracciolo, G. (2020) · Sensors International · doi:10.1016/j.sintl.2020.100025 · Cited by 22 · see citing works

An investigation of the effect of the protein corona on the cellular uptake of nanoliposomes under flow conditions using quartz crystal microgravimetry with dissipation

der Sanden, N. V., Paun, R. A., Yitayew, M. Y., Boyadjian, O., & Tabrizian, M. (2024) · Nanoscale Advances · doi:10.1039/d4na00783b · Cited by 21 · see citing works

A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression

Palchetti, S., Digiacomo, L., Giulimondi, F., Pozzi, D., Peruzzi, G., Ferri, G., Amenitsch, H. W., Cardarelli, F., Mahmoudi, M., & Caracciolo, G. (2019) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2019.183159 · Cited by 21 · see citing works

Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery

Naeem, S., Viswanathan, G., & Misran, M. (2017) · Reviews in Chemical Engineering · doi:10.1515/revce-2016-0018 · Cited by 21 · see citing works

Polyethylenimine-coated iron oxide magnetic nanoparticles for high efficient gene delivery

Anh, N. T. V., Abdelrasoul, G. N., Lin, D., Maadi, H., Tong, J., Chen, G., Wang, R., Anwar, A., Shoute, L. C. T., Fang, Q., et al. (2018) · Applied Nanoscience · doi:10.1007/s13204-018-0775-z · Cited by 21 · see citing works

Factors Influencing the Immunogenicity and Immunotoxicity of Cyclic RGD Peptide-Modified Nanodrug Delivery Systems

Wang, X., Meng, N., Wang, S., Lu, L., Wang, H., Zhan, C., Burgess, D. J., & Lu, W. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00394 · Cited by 20 · see citing works

Effects of the protein corona on liposome–liposome and liposome–cell interactions

Tasciotti, E., Molinaro, R., Taraballi, F., Furman, N. E. T., Sherman, M. B., Parodi, A., Salvatore, F., & Corbo, C. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s109059 · Cited by 104 · see citing works

Protein Corona Fingerprints of Liposomes: New Opportunities for Targeted Drug Delivery and Early Detection in Pancreatic Cancer

Palchetti, S., Caputo, D. D., Digiacomo, L., Capriotti, A. L., Coppola, R., Pozzi, D., & Caracciolo, G. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11010031 · Cited by 57 · see citing works

Prediction of nanoparticles-cell association based on corona proteins and physicochemical properties

Liu, R., Jiang, W., Walkey, C., Chan, W. C. W., & Cohen, Y. (2015) · Nanoscale · doi:10.1039/c5nr01537e · Cited by 147 · see citing works

The liposome as a distribution model in QSAR studies

Betageri, G. V., & Rogers, J. A. (1988) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(88)90014-2 · Cited by 60 · see citing works

Quantitative Structure-Activity Relationships for Cellular Uptake of Surface-Modified Nanoparticles

Liu, R., Ralló, R., Bilal, M., & Cohen, Y. (2015) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207318666150306105525 · Cited by 10 · see citing works