The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Ultrasmall Ferrite Nanoparticles Synthesized via Dynamic Simultaneous Thermal Decomposition for High-Performance and Multifunctional T1 Magnetic Resonance Imaging Contrast Agent
Abstract
Large-scale synthesis of monodisperse ultrasmall metal ferrite nanoparticles as well as understanding the correlations between chemical composition and MR signal enhancement is critical for developing next-generation, ultrasensitive T 1 magnetic resonance imaging (MRI) nanoprobes. Herein, taking ultrasmall MnFe 2 O 4 nanoparticles (UMFNPs) as a model system, we report a general dynamic simultaneous thermal decomposition (DSTD) strategy for controllable synthesis of monodisperse ultrasmall metal ferrite nanoparticles with sizes smaller than 4 nm. The comparison study revealed that the DSTD using the iron-eruciate paired with a metal-oleate precursor enabled a nucleation-doping process, which is crucial for particle size and distribution control of ultrasmall metal ferrite nanoparticles. The principle of DSTD synthesis has been further confirmed by synthesizing NiFe 2 O 4 and CoFe 2 O 4 nanoparticles with well-controlled sizes of ∼3 nm. More significantly, the success in DSTD synthesis allows us to tune both MR and biochemical properties of magnetic iron oxide nanoprobes by adjusting their chemical composition. Beneficial from the Mn 2+ dopant, the synthesized UMFNPs exhibited the highest r 1 relaxivity (up to 8.43 mM –1 s –1 ) among the ferrite nanoparticles with similar sizes reported so far and demonstrated a multifunctional T 1 MR nanoprobe for in vivo high-resolution blood pool and liver-specific MRI simultaneously. Our study provides a general strategy to synthesize ultrasmall multicomponent magnetic nanoparticles, which offers possibilities for the chemical design of a highly sensitive ultrasmall magnetic nanoparticle based T 1 MRI probe for various clinical diagnosis applications.
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Cites
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
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Tromsdorf, U. I., Bruns, O. T., Salmen, S. C., Beisiegel, U., & Weller, H. (2009) · Nano Letters · doi:10.1021/nl902715v · Cited by 396
MR angiography with blood pool contrast agents
Bremerich, J., Bilecen, D., & Reimer, P. (2007) · European Radiology · doi:10.1007/s00330-007-0712-0 · Cited by 139
Cited by
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
Ni, D., Bu, W., Ehlerding, E. B., Cai, W., & Shi, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00316a · Cited by 484
Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
Zhao, N., Yan, L., Zhao, X., Chen, X., Li, A., Zheng, D., Zhou, X., Dai, X., & Xu, F.-J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00401 · Cited by 429
Magnetic Nanoparticles as MRI Contrast Agents
Avasthi, A., Caro, C., Pozo-Torres, E., Leal, M. P., & García-Martín, M. L. (2020) · Topics in Current Chemistry · doi:10.1007/s41061-020-00302-w · Cited by 253
Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications
Monteserín, M., Larumbe, S., Martínez, A. V., Burgui, S., & Francisco Martín, L. (2021) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2021.19062 · Cited by 27
Metadata
- Authors
- Zhang, H., Li, L., Liu, X. L., Jiao, J., Ng, C.-T., Yi, J. B., Luo, Y. E., Bay, B.-H., Zhao, L. Y., Peng, M. L., Gu, N., & Fan, H. M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-04-06
- Volume
- 11
- Issue
- 4
- Pages
- 3614-3631
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2604615809
- Cited by
- 224
- References
- 6
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- closed
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