A Highly Effective, Nontoxic T1 MR Contrast Agent Based on Ultrasmall PEGylated Iron Oxide Nanoparticles
Abstract
In this study we systematically developed a potential MR T(1) contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under physiological conditions together with low cytotoxicity and low nonspecific phagocytosis into macrophage cells as a part of the reticulo endothelial system at biologically relevant concentrations. The as developed contrast agent has the lowest r(2)/r(1) ratio (2.4) at 1.41 T reported so far for PEGylated iron oxide nanoparticles as well as a r(1) relaxivity (7.3 mM(-1) s(-1)) that is two times higher compared to that of Magnevist as a typical T(1) contrast agent based on gadolinium as a clinical standard.
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The organic shell surrounding the iron oxide core needs to be stable under physiological conditions and prevent aggregation, as aggregation would result in undesired T2 contrast enhancement.
“In addition, the organic shell surrounding the core needs to be stable under physiological conditions and it needs to prevent the aggregation of individual nanoparticles, as this would result in an undesired T2 contrast enhancement [141, 142].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [141]
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- Authors
- Tromsdorf, U. I., Bruns, O. T., Salmen, S. C., Beisiegel, U., & Weller, H.
- Affiliations
- Universität Hamburg (DE)
- Institute of Physical Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany, and IBM II: Molecular Cell Biology, University Medical Center Hamburg—Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
- Corresponding author
- Tromsdorf, Ulrich I.
- Weller, Horst
- ORCID
- Weller, Horst
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-10-02
- Volume
- 9
- Issue
- 12
- Pages
- 4434-4440
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2089553795
- Cited by
- 396
- References
- 37
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 13 · 2023: 18 · 2022: 14 · 2021: 27 · 2020: 19 · 2019: 35 · 2018: 22 · 2017: 33 · 2016: 29 · 2015: 26 · 2014: 42 · 2013: 26 · 2012: 36
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- T1 contrast agents, ultrasmall nanoparticles, relaxivity, T1 relaxivity, r2/r1 ratio, nanoparticle size optimization, polyethylene glycol coating, cytotoxicity, phagocytosis, reticuloendothelial system, gadolinium-based contrast agents
- MeSH terms
- Cells, Cultured, Contrast Media, Drug Carriers, Ferric Compounds, Humans, Image Enhancement, Macrophages, Magnetic Resonance Imaging, Particle Size, Polyethylene Glycols, Nanoparticles
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