Cited by 396Characterization and Applications of Magnetic NanoparticlesLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and Applications

A Highly Effective, Nontoxic T1 MR Contrast Agent Based on Ultrasmall PEGylated Iron Oxide Nanoparticles

Tromsdorf, Ulrich I., Bruns, Oliver T., Salmen, Sunhild C., Beisiegel, Ulrike, Weller, Horst·2009·Nano Letters

Abstract

In this study we systematically developed a potential MR T(1) contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under physiological conditions together with low cytotoxicity and low nonspecific phagocytosis into macrophage cells as a part of the reticulo endothelial system at biologically relevant concentrations. The as developed contrast agent has the lowest r(2)/r(1) ratio (2.4) at 1.41 T reported so far for PEGylated iron oxide nanoparticles as well as a r(1) relaxivity (7.3 mM(-1) s(-1)) that is two times higher compared to that of Magnevist as a typical T(1) contrast agent based on gadolinium as a clinical standard.

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Crossref · 10.1021/nl902715v

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  • The organic shell surrounding the iron oxide core needs to be stable under physiological conditions and prevent aggregation, as aggregation would result in undesired T2 contrast enhancement.

    “In addition, the organic shell surrounding the core needs to be stable under physiological conditions and it needs to prevent the aggregation of individual nanoparticles, as this would result in an undesired T2 contrast enhancement [141, 142].”

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Authors
Tromsdorf, U. I., Bruns, O. T., Salmen, S. C., Beisiegel, U., & Weller, H.
Affiliations
  • Universität Hamburg (DE)
  • Institute of Physical Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany, and IBM II: Molecular Cell Biology, University Medical Center Hamburg—Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
Corresponding author
  • Tromsdorf, Ulrich I.
  • Weller, Horst
Venue
Nano Letters
Published
2009-10-02
Volume
9
Issue
12
Pages
4434-4440
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W2089553795
Cited by
396
References
37
Citations by year
2026: 2 · 2025: 8 · 2024: 13 · 2023: 18 · 2022: 14 · 2021: 27 · 2020: 19 · 2019: 35 · 2018: 22 · 2017: 33 · 2016: 29 · 2015: 26 · 2014: 42 · 2013: 26 · 2012: 36
FWCI
16.25
Type
journal article
Language
en
Open access
closed
Locations
  • Nano Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
T1 contrast agents, ultrasmall nanoparticles, relaxivity, T1 relaxivity, r2/r1 ratio, nanoparticle size optimization, polyethylene glycol coating, cytotoxicity, phagocytosis, reticuloendothelial system, gadolinium-based contrast agents
MeSH terms
Cells, Cultured, Contrast Media, Drug Carriers, Ferric Compounds, Humans, Image Enhancement, Macrophages, Magnetic Resonance Imaging, Particle Size, Polyethylene Glycols, Nanoparticles

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