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Cited by 561

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Microfluidic Electroporation-Facilitated Synthesis of Erythrocyte Membrane-Coated Magnetic Nanoparticles for Enhanced Imaging-Guided Cancer Therapy

Rao, Lang, Cai, Bo, Bu, Lin-Lin, Liao, Qing-Quan, Guo, Shi-Shang, Zhao, Xing-Zhong, Dong, Wen-Fei, Liu, Wei·2017·ACS Nano
DOI 10.1021/acsnano.7b00133
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Abstract

Biomimetic cell membrane-coated nanoparticles (CM-NPs) with superior biochemical properties have been broadly utilized for various biomedical applications. Currently, researchers primarily focus on using ultrasonic treatment and mechanical extrusion to improve the synthesis of CM-NPs. In this work, we demonstrate that microfluidic electroporation can effectively facilitate the synthesis of CM-NPs. To test it, Fe 3 O 4 magnetic nanoparticles (MNs) and red blood cell membrane-derived vesicles (RBC-vesicles) are infused into a microfluidic device. When the mixture of MNs and RBC-vesicles flow through the electroporation zone, the electric pulses can effectively promote the entry of MNs into RBC-vesicles. After that, the resulting RBC membrane-capped MNs (RBC-MNs) are collected from the chip and injected into experimental animals to test the in vivo performance. Owing to the superior magnetic and photothermal properties of the MN cores and the long blood circulation characteristic of the RBC membrane shells, core–shell RBC-MNs were used for enhanced tumor magnetic resonance imaging (MRI) and photothermal therapy (PTT). Due to the completer cell membrane coating, RBC-MNs prepared by microfluidic electroporation strategy exhibit significantly better treatment effect than the one fabricated by conventional extrusion. We believe the combination of microfluidic electroporation and CM-NPs provides an insight into the synthesis of bioinpired nanoparticles to improve cancer diagnosis and therapy.

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Metadata

Authors
Rao, L., Cai, B., Bu, L.-L., Liao, Q.-Q., Guo, S.-S., Zhao, X.-Z., Dong, W.-F., & Liu, W.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2017-03-13
Volume
11
Issue
4
Pages
3496-3505
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
DOI
10.1021/acsnano.7b00133
OpenAlex
W2593852474
Cited by
561
References
59
FWCI
15.36
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Microfluidic Electroporation-Facilitated Synthesis of Erythrocyte Membrane-Coated Magnetic Nanoparticles for Enhanced Imaging-Guided Cancer Therapy. https://app.cochat.ai/papers/10.1021/acsnano.7b00133
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Rao, L., Cai, B., Bu, L.-L., Liao, Q.-Q., Guo, S.-S., Zhao, X.-Z., Dong, W.-F., & Liu, W. (2017). Microfluidic Electroporation-Facilitated Synthesis of Erythrocyte Membrane-Coated Magnetic Nanoparticles for Enhanced Imaging-Guided Cancer Therapy. ACS Nano. https://doi.org/10.1021/acsnano.7b00133

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