The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cancer Cell Membrane Camouflaged Cascade Bioreactor for Cancer Targeted Starvation and Photodynamic Therapy
Abstract
Selectively cuting off the nutrient supply and the metabolism pathways of cancer cells would be a promising approach to improve the efficiency of cancer treatment. Here, a cancer targeted cascade bioreactor (designated as mCGP) was constructed for synergistic starvation and photodynamic therapy (PDT) by embedding glucose oxidase (GOx) and catalase in the cancer cell membrane-camouflaged porphyrin metal–organic framework (MOF) of PCN-224 (PCN stands for porous coordination network). Due to biomimetic surface functionalization, the immune escape and homotypic targeting behaviors of mCGP would dramatically enhance its cancer targeting and retention abilities. Once internalized by cancer cells, mCGP was found to promote microenvironmental oxygenation by catalyzing the endogenous hydrogen peroxide (H 2 O 2 ) to produce oxygen (O 2 ), which would subsequently accelerate the decomposition of intracellular glucose and enhance the production of cytotoxic singlet oxygen ( 1 O 2 ) under light irradiation. Consequently, mCGP displayed amplified synergistic therapeutic effects of long-term cancer starvation therapy and robust PDT, which would efficiently inhibit the cancer growth after a single administration. This cascade bioreactor would further facilitate the development of complementary modes for spatiotemporally controlled cancer treatment.
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Cites
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Self-citationCell or Cell Membrane-Based Drug Delivery Systems
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Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways
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Cell Membrane Coating Nanotechnology
Fang, R. H., Kroll, A. V., Gao, W., & Zhang, L. (2018) · Advanced Materials · doi:10.1002/adma.201706759 · Cited by 1,885
Self-citationTargeting drugs to tumours using cell membrane-coated nanoparticles
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Self-citationNanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy
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Self-citationYang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Metadata
- Authors
- Li, S.-Y., Cheng, H., Xie, B.-R., Qiu, W.-X., Zeng, J.-Y., Li, C.-X., Wan, S.-S., Zhang, L., Liu, W.-L., & Zhang, X.-Z.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-07-05
- Volume
- 11
- Issue
- 7
- Pages
- 7006-7018
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2729471090
- Cited by
- 780
- References
- 9
- FWCI
- 37.13
- Type
- journal article
- Language
- en
- Open access
- closed
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