The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Multifunctional Bacteria-Driven Microswimmers for Targeted Active Drug Delivery
Abstract
High-performance, multifunctional bacteria-driven microswimmers are introduced using an optimized design and fabrication method for targeted drug delivery applications. These microswimmers are made of mostly single Escherichia coli bacterium attached to the surface of drug-loaded polyelectrolyte multilayer (PEM) microparticles with embedded magnetic nanoparticles. The PEM drug carriers are 1 μm in diameter and are intentionally fabricated with a more viscoelastic material than the particles previously studied in the literature. The resulting stochastic microswimmers are able to swim at mean speeds of up to 22.5 μm/s. They can be guided and targeted to specific cells, because they exhibit biased and directional motion under a chemoattractant gradient and a magnetic field, respectively. Moreover, we demonstrate the microswimmers delivering doxorubicin anticancer drug molecules, encapsulated in the polyelectrolyte multilayers, to 4T1 breast cancer cells under magnetic guidance in vitro. The results reveal the feasibility of using these active multifunctional bacteria-driven microswimmers to perform targeted drug delivery with significantly enhanced drug transfer, when compared with the passive PEM microparticles.
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Citations
Cites
Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites
Decher, G. (1997) · Science · doi:10.1126/science.277.5330.1232 · Cited by 10,054
Verwendung von Schwingquarzen zur W�gung d�nner Schichten und zur Mikrow�gung
Sauerbrey, G. (1959) · Zeitschrift f�r Physik · doi:10.1007/bf01337937 · Cited by 9,653
Use of quartz vibration for weighing thin films on a microbalance
Sauerbrey, G., & Sauerbrey, F. (1959) · The European Physical Journal A · Cited by 6,791
Preparation of aqueous magnetic liquids in alkaline and acidic media
Massart, R. (1981) · IEEE Transactions on Magnetics · doi:10.1109/tmag.1981.1061188 · Cited by 2,817
Voinova, M. V., Rodahl, M., Jonson, M., & Kasemo, B. (1999) · Physica Scripta · doi:10.1238/physica.regular.059a00391 · Cited by 1,587
Physics of microswimmers—single particle motion and collective behavior: a review
Elgeti, J., Winkler, R. G., & Gompper, G. (2015) · Reports on Progress in Physics · doi:10.1088/0034-4885/78/5/056601 · Cited by 1,514
Physico-chemistry of initial microbial adhesive interactions – its mechanisms and methods for study
Bos, R. (1999) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1999.tb00396.x · Cited by 1,216
Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions
Felfoul, O., Mohammadi, M., Taherkhani, S., de Lanauze, D., Zhong Xu, Y., Loghin, D., Essa, S., Jancik, S., Houle, D., Lafleur, M., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.137 · Cited by 1,106
Chemically Powered Micro‐ and Nanomotors
Sánchez, S., Soler, L., & Katuri, J. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201406096 · Cited by 1,011
Lösche, M., Schmitt, J., Decher, G., Bouwman, W. G., & Kjaer, K. (1998) · Macromolecules · doi:10.1021/ma980910p · Cited by 587
Moving Fluid with Bacterial Carpets
Darnton, N., Turner, L., Breuer, K., & Berg, H. C. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74253-8 · Cited by 376
Bioengineered and biohybrid bacteria-based systems for drug delivery
Hosseinidoust, Z., Mostaghaci, B., Yasa, O., Park, B.-W., Singh, A. V., & Sitti, M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.09.007 · Cited by 368
Self-citationA hydrogel-based microfluidic device for the studies of directed cell migration
Cheng, S.-Y., Heilman, S., Wasserman, M., Archer, S., Shuler, M. L., & Wu, M. (2007) · Lab on a Chip · doi:10.1039/b618463d · Cited by 359
Bacterial flagella-based propulsion and on/off motion control of microscale objects
Behkam, B., & Sitti, M. (2007) · Applied Physics Letters · doi:10.1063/1.2431454 · Cited by 348
Self-citationBacteria-mediated delivery of nanoparticles and cargo into cells
Akin, D., Sturgis, J., Ragheb, K., Sherman, D., Burkholder, K., Robinson, J. P., Bhunia, A. K., Mohammed, S., & Bashir, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.149 · Cited by 347
Gribova, V., Auzely-Velty, R., & Picart, C. (2012) · Chemistry of Materials · doi:10.1021/cm2032459 · Cited by 338
Bio‐Hybrid Cell‐Based Actuators for Microsystems
Carlsen, R. W., & Sitti, M. (2014) · Small · doi:10.1002/smll.201400384 · Cited by 231
Self-citationNew paradigm for tumor theranostic methodology using bacteria-based microrobot
Park, S. J., Park, S.-H., Cho, S., Kim, D.-M., Lee, Y., Ko, S. Y., Hong, Y., Choy, H. E., Min, J.-J., Park, J.-O., et al. (2013) · Scientific Reports · doi:10.1038/srep03394 · Cited by 230
Failed Escape: Solid Surfaces Prevent Tumbling of Escherichia coli
Molaei, M., Barry, M., Stocker, R., & Sheng, J. (2014) · Physical Review Letters · doi:10.1103/physrevlett.113.068103 · Cited by 226
Substrata Mechanical Stiffness Can Regulate Adhesion of Viable Bacteria
Lichter, J. A., Thompson, M. T., Delgadillo, M., Nishikawa, T., Rubner, M. F., & Van Vliet, K. J. (2008) · Biomacromolecules · doi:10.1021/bm701430y · Cited by 224
Substrata Mechanical Stiffness Can Regulate Adhesion of Viable Bacteria
Lichter, J. A., Thompson, M. T., Delgadillo, M., Nishikawa, T., Rubner, M. F., & Van Vliet, K. J. (2008) · Biomacromolecules · doi:10.1021/bm8009335 · Cited by 173
Mamedov, A., Ostrander, J., Aliev, F., & Kotov, N. A. (2000) · Langmuir · doi:10.1021/la990957j · Cited by 165
Effect of quantity and configuration of attached bacteria on bacterial propulsion of microbeads
Behkam, B., & Sitti, M. (2008) · Applied Physics Letters · doi:10.1063/1.3040318 · Cited by 152
Self-citationMagnetic steering control of multi-cellular bio-hybrid microswimmers
Carlsen, R. W., Edwards, M. R., Jiang, Z., Pacoret, C., & Sitti, M. (2014) · Lab on a Chip · doi:10.1039/c4lc00707g · Cited by 151
Self-citationNguyen, V. D., Han, J., Choi, Y. J., Cho, S., Zheng, S., Ko, S. Y., Park, J., & Park, S. (2015) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2015.09.034 · Cited by 150
Epps, H. M. R., & Gale, E. F. (1942) · Biochemical Journal · doi:10.1042/bj0360619 · Cited by 145
Feng, W., Zhou, X., He, C., Qiu, K., Nie, W., Chen, L., Wang, H., Mo, X., & Zhang, Y. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21193b · Cited by 139
pH-Taxis of Biohybrid Microsystems
Jiang, Z., Carlsen, R. W., & Sitti, M. (2015) · Scientific Reports · doi:10.1038/srep11403 · Cited by 122
Self-citationToward Therapeutic Delivery with Layer-by-Layer Engineered Particles
Yan, Y., Such, G. K., Johnston, A. P. R., Lomas, H., & Caruso, F. (2011) · ACS Nano · doi:10.1021/nn201793f · Cited by 118
Pseudomonas aeruginosa Attachment on QCM-D Sensors: The Role of Cell and Surface Hydrophobicities
Marcus, I. M., Herzberg, M., Walker, S. L., & Freger, V. (2012) · Langmuir · doi:10.1021/la300333c · Cited by 116
Chemotaxis of bio-hybrid multiple bacteria-driven microswimmers
Jiang, Z., & Sitti, M. (2016) · Scientific Reports · doi:10.1038/srep32135 · Cited by 110
Self-citationYoung's Modulus of Polyelectrolyte Multilayers from Microcapsule Swelling
Vinogradova, O. I., Andrienko, D., Lulevich, V. V., Nordschild, S., & Sukhorukov, G. B. (2004) · Macromolecules · doi:10.1021/ma0350213 · Cited by 104
Magnetically directed self-assembly of submicron spheres with a Fe3O4 nanoparticle shell
Bizdoaca, E. L., Spasova, M., Farle, M., et al. (2002) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(01)00724-7 · Cited by 93
Recent progress in bio-sensing techniques with encapsulated enzymes
Park, B.-W., Yoon, D.-Y., & Kim, D. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.04.033 · Cited by 91
Self-citationLi, D., Choi, H., Cho, S., Jeong, S., Jin, Z., Lee, C., Ko, S. Y., Park, J., & Park, S. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25555 · Cited by 80
Liu, J., Zhang, Y., Wang, C., Xu, R., Chen, Z., & Gu, N. (2010) · The Journal of Physical Chemistry C · doi:10.1021/jp911933b · Cited by 73
Effect of body shape on the motile behavior of bacteria-powered swimming microrobots (BacteriaBots)
Sahari, A., Headen, D. M., & Behkam, B. (2012) · Biomedical Microdevices · doi:10.1007/s10544-012-9712-1 · Cited by 66
Near and far-wall effects on the three-dimensional motion of bacteria-driven microbeads
Edwards, M. R., Carlsen, R. W., & Sitti, M. (2013) · Applied Physics Letters · doi:10.1063/1.4801810 · Cited by 57
Self-citationSolé, M., Rius, N., & Lorén, J. G. (2000) · PubMed · Cited by 51
Patterned and Specific Attachment of Bacteria on Biohybrid Bacteria‐Driven Microswimmers
Singh, A. V., & Sitti, M. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600155 · Cited by 48
Self-citationStudy of Bacterial Adhesion on Biomimetic Temperature Responsive Glycopolymer Surfaces
Wang, Y., Kotsuchibashi, Y., Liu, Y., & Narain, R. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am508792k · Cited by 45
Uthaman, S., Zheng, S., Han, J., Choi, Y. J., Cho, S., Nguyen, V. D., Park, J., Park, S., Min, J., Park, S., et al. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500556 · Cited by 42
Nagy, K. S., Pilbat, A., Groma, G. I., Szalontai, B., & Cuisinier, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.151167 · Cited by 22
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Ricotti, L., Trimmer, B., Feinberg, A. W., Raman, R., Parker, K. K., Bashir, R., Sitti, M., Martel, S., Dario, P., & Menciassi, A. (2017) · Science Robotics · doi:10.1126/scirobotics.aaq0495 · Cited by 527
Self-citationSoft erythrocyte-based bacterial microswimmers for cargo delivery
Alapan, Y., Yasa, O., Schauer, O., Giltinan, J., Tabak, A. F., Sourjik, V., & Sitti, M. (2018) · Science Robotics · doi:10.1126/scirobotics.aar4423 · Cited by 420
Self-citationAkolpoglu, M. B., Alapan, Y., Dogan, N. O., Baltaci, S. F., Yasa, O., Aybar Tural, G., & Sitti, M. (2022) · Science Advances · doi:10.1126/sciadv.abo6163 · Cited by 293
Self-citationDong, X., & Sitti, M. (2020) · The International Journal of Robotics Research · doi:10.1177/0278364920903107 · Cited by 198
Self-citationPromising dawn in tumor microenvironment therapy: engineering oral bacteria
Wang, Z., Sun, W., Hua, R., Wang, Y., Li, Y., & Zhang, H. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00282-3 · Cited by 97
Metadata
- Authors
- Park, B.-W., Zhuang, J., Yasa, O., & Sitti, M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-09-11
- Volume
- 11
- Issue
- 9
- Pages
- 8910-8923
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2752071174
- Cited by
- 384
- References
- 43
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- closed
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