The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Next-Generation Lipids in RNA Interference Therapeutics
Open accessAbstract
RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery vehicles. In this aspect, lipid nanoparticles (LNPs) are the most advanced platform among nonviral vectors for gene delivery. In this review, we critically review the literature and the reasons for ineffective delivery beyond the liver. We discuss the toxicity issues associated with permanently charged cationic lipids and then turn our attention to next-generation ionizable cationic lipids. These lipids exhibit reduced toxicity and immunogenicity and undergo ionization under the acidic environment of the endosome to release the encapsulated payload to their site of action in the cytosol. Finally, we summarize recent achievements in therapeutic nucleic acid delivery and report on the current status of clinical trials using LNP and the obstacles to clinical translation.
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Cites
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Cited by
The current state and future directions of RNAi-based therapeutics
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Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
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Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles
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Self-citationChallenges of Storage and Stability of mRNA-Based COVID-19 Vaccines
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Metadata
- Authors
- Rietwyk, S., & Peer, D.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-07-24
- Volume
- 11
- Issue
- 8
- Pages
- 7572-7586
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2738497284
- Cited by
- 199
- References
- 21
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- green
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