The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Engineered Exosome-Mediated Near-Infrared-II Region V2C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy
Abstract
The limited penetration depth of photothermal agents (PTAs) active in the NIR-I biowindow and the thermoresistance caused by heat shock protein (HSP) significantly limit the therapeutic efficiency of photothermal therapy (PTT). To address the problem, we introduce a strategy of low-temperature nucleus-targeted PTT in the NIR-II region achieving effective tumor killing by combining the vanadium carbide quantum dots (V 2 C QDs) PTA and an engineered exosomes (Ex) vector. The small fluorescent V 2 C QDs with good photothermal effect in the NIR-II region were modified with TAT peptides and packaged into Ex with RGD modification (V 2 [email protected] ). The resulting nanoparticles (NPs) exhibited good biocompatibility, long circulation time, and endosomal escape ability, and they could target the cell and enter into the nucleus to realize low-temperature PTT with advanced tumor destruction efficiency. The fluorescent imaging, photoacoustic imaging (PAI), and magnetic resonance imaging (MRI) capability of the NPs were also revealed. The low-temperature nucleus-targeted PTT in the NIR-II region provides more possibilities toward successful clinical application of PTT.
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Cites
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Self-citationA route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287
Exosome-coated metal–organic framework nanoparticles: an efficient drug delivery platform
Illes, B., Hirschle, P., Barnert, S., Cauda, V., Wuttke, S., & Engelke, H. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.7b02358 · Cited by 215
Cited by
Engineering exosomes for targeted drug delivery
Liang, Y., Duan, L., Lu, J., & Xia, J. (2021) · Theranostics · doi:10.7150/thno.52570 · Cited by 1,547
Second near-infrared photothermal materials for combinational nanotheranostics
Xu, C., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00664e · Cited by 941
A Review on MXene Synthesis, Stability, and Photocatalytic Applications
Murali, G., Reddy Modigunta, J. K., Park, Y. H., Lee, J.-H., Rawal, J., Lee, S.-Y., In, I., & Park, S.-J. (2022) · ACS Nano · doi:10.1021/acsnano.2c04750 · Cited by 668
Two‐Dimensional Nanomaterials for Photothermal Therapy
Liu, S., Pan, X., & Liu, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201911477 · Cited by 592
Exosome engineering: Current progress in cargo loading and targeted delivery
Fu, S., Wang, Y., Xia, X., & Zheng, J. C. (2020) · NanoImpact · doi:10.1016/j.impact.2020.100261 · Cited by 444
Metadata
- Authors
- Cao, Y., Wu, T., Zhang, K., Meng, X., Dai, W., Wang, D., Dong, H., & Zhang, X.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-01-29
- Volume
- 13
- Issue
- 2
- Pages
- 1499-1510
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2912552613
- Cited by
- 279
- References
- 3
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- closed
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